Assessment of the efficacy of interceed after hysterectomy in preventing adhesion formation in the rabbit model

Tracy Wheelock, Donald G. Gallup, Leo Plouffe, William Metheny

Research output: Contribution to journalArticle

Abstract

Objective The purpose of this study was to evaluate the effectiveness of oxidized regenerated cellulose in preventing adhesions after hysterectomy when placed over a peritoneal defect after the vaginal cuff was closed. Methods Thirty rabbits who underwent hysterectomy were randomized into one of three groups: (1) in 10 there was no reperitonealization, (2) in 10 pelvic peritonea were closed with a running stitch of 6-0 polyglycolic acid suture, and (3) in 10 oxidized regenerated cellulose was placed over the peritoneal defect. Two weeks after the initial operative procedure, the animals were killed. Adhesions were scored for tenacity and percent of defect covered by adhesions. Results Comparison of the three groups by analysis of variance revealed no statistical significance in either the tenacity of adhesions (p = 0.9508) or the extent of surface with adhesions (p = 0.1862). However, the lowest mean adhesion scores were noted in the spontaneously healed defect group, followed by the suture closure group, followed by the oxidized regenerated cellulose group. Conclusions These data suggest that, in the rabbit model, spontaneous closure of peritoneal defects after major pelvic surgery allows for better healing than suture reapproximation or antiadhesion barrier (oxidized regenerated cellulose) usage on these surfaces.

Original languageEnglish (US)
Pages (from-to)67-70
Number of pages4
JournalJournal of Pelvic Surgery
Volume4
Issue number2
StatePublished - Jan 1 1997
Externally publishedYes

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oxidized cellulose
Hysterectomy
Sutures
Rabbits
Polyglycolic Acid
Peritoneum
Operative Surgical Procedures
Running
Analysis of Variance

All Science Journal Classification (ASJC) codes

  • Surgery
  • Obstetrics and Gynecology
  • Urology

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Assessment of the efficacy of interceed after hysterectomy in preventing adhesion formation in the rabbit model. / Wheelock, Tracy; Gallup, Donald G.; Plouffe, Leo; Metheny, William.

In: Journal of Pelvic Surgery, Vol. 4, No. 2, 01.01.1997, p. 67-70.

Research output: Contribution to journalArticle

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AB - Objective The purpose of this study was to evaluate the effectiveness of oxidized regenerated cellulose in preventing adhesions after hysterectomy when placed over a peritoneal defect after the vaginal cuff was closed. Methods Thirty rabbits who underwent hysterectomy were randomized into one of three groups: (1) in 10 there was no reperitonealization, (2) in 10 pelvic peritonea were closed with a running stitch of 6-0 polyglycolic acid suture, and (3) in 10 oxidized regenerated cellulose was placed over the peritoneal defect. Two weeks after the initial operative procedure, the animals were killed. Adhesions were scored for tenacity and percent of defect covered by adhesions. Results Comparison of the three groups by analysis of variance revealed no statistical significance in either the tenacity of adhesions (p = 0.9508) or the extent of surface with adhesions (p = 0.1862). However, the lowest mean adhesion scores were noted in the spontaneously healed defect group, followed by the suture closure group, followed by the oxidized regenerated cellulose group. Conclusions These data suggest that, in the rabbit model, spontaneous closure of peritoneal defects after major pelvic surgery allows for better healing than suture reapproximation or antiadhesion barrier (oxidized regenerated cellulose) usage on these surfaces.

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