Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer - Evidence of effect modification by prostate size

Jay Fowke, Saundra Motley, Qi Dai, Raoul Concepcion, Daniel A. Barocas

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Prostate enlargement is common with aging and obesity. We investigated the association between obesity and prostate cancer controlling for differential detection related to prostate enlargement. In an analysis of 500 men, we found body mass index, waist-hip ratio, and blood leptin levels were significantly associated with high-grade PC, but only among men without prostate enlargement. Leptin was also significantly associated with high-grade prostatic intraepithelial neoplasia (HGPIN) in the absence of prostate enlargement. Our results suggest obesity advances prostate carcinogenesis, and that detection biases at prostate biopsy may explain past inconsistencies in the association between obesity and PC.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalCancer Letters
Volume328
Issue number2
DOIs
StatePublished - Jan 28 2013
Externally publishedYes

Fingerprint

Prostatic Intraepithelial Neoplasia
Prostate
Prostatic Neoplasms
Obesity
Biomarkers
Leptin
Waist-Hip Ratio
Carcinogenesis
Body Mass Index
Biopsy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer - Evidence of effect modification by prostate size. / Fowke, Jay; Motley, Saundra; Dai, Qi; Concepcion, Raoul; Barocas, Daniel A.

In: Cancer Letters, Vol. 328, No. 2, 28.01.2013, p. 345-352.

Research output: Contribution to journalArticle

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