Association between body powder use and ovarian cancer

The African American Cancer Epidemiology Study (AACES)

Joellen M. Schildkraut, Sarah E. Abbott, Anthony J. Alberg, Elisa V. Bandera, Jill S. Barnholtz-Sloan, Melissa L. Bondy, Michele L. Cote, Ellen Funkhouser, Lauren C. Peres, Edward S. Peters, Ann G. Schwartz, Paul Terry, Sydnee Crankshaw, Fabian Camacho, Frances Wang, Patricia G. Moorman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Epidemiologic studies indicate increased ovarian cancer risk among women who use genital powder, but this has not been thoroughly investigated in African American (AA) women, a group with a high prevalence of use. We evaluate the relationship between use of genital powder and nongenital powder in invasive epithelial ovarian cancer (EOC). Methods: Subjects are 584 cases and 745 controls enrolled in the African American Cancer Epidemiology Study (AACES), an ongoing, population-based case-control study of EOC in AA women in 11 geographic locations in the United States. AA controls were frequency matched to cases on residence and age. Logistic regression was used to calculate ORs and 95% confidence intervals (CI) for associations between genital and nongenital powder exposure and EOC risk, controlling for potential confounders. Results: Powder use was common (62.8% of cases and 52.9% of controls). Genital powder was associated with an increased risk of EOC (OR = 1.44; 95% CI, 1.11-1.86) and a dose-response relationship was found for duration of use and number of lifetime applications (P < 0.05). Nongenital use was also associated with EOC risk, particularly among nonserous EOC cases (OR = 2.28; 95% CI, 1.39-3.74). An association between powder use and upper respiratory conditions suggests an enhanced inflammatory response may explain the association between body powder and EOC. Conclusions: In a study of AA women, body powder use was significantly associated with EOC risk. Impact: The results support that body powder is a modifiable risk factor for EOC among AA women.

Original languageEnglish (US)
Pages (from-to)1411-1417
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume25
Issue number10
DOIs
StatePublished - Oct 1 2016

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African Americans
Ovarian Neoplasms
Powders
Epidemiology
Neoplasms
Confidence Intervals
Ovarian epithelial cancer
Geographic Locations
Case-Control Studies
Epidemiologic Studies
Logistic Models

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Schildkraut, J. M., Abbott, S. E., Alberg, A. J., Bandera, E. V., Barnholtz-Sloan, J. S., Bondy, M. L., ... Moorman, P. G. (2016). Association between body powder use and ovarian cancer: The African American Cancer Epidemiology Study (AACES). Cancer Epidemiology Biomarkers and Prevention, 25(10), 1411-1417. https://doi.org/10.1158/1055-9965.EPI-15-1281

Association between body powder use and ovarian cancer : The African American Cancer Epidemiology Study (AACES). / Schildkraut, Joellen M.; Abbott, Sarah E.; Alberg, Anthony J.; Bandera, Elisa V.; Barnholtz-Sloan, Jill S.; Bondy, Melissa L.; Cote, Michele L.; Funkhouser, Ellen; Peres, Lauren C.; Peters, Edward S.; Schwartz, Ann G.; Terry, Paul; Crankshaw, Sydnee; Camacho, Fabian; Wang, Frances; Moorman, Patricia G.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 25, No. 10, 01.10.2016, p. 1411-1417.

Research output: Contribution to journalArticle

Schildkraut, JM, Abbott, SE, Alberg, AJ, Bandera, EV, Barnholtz-Sloan, JS, Bondy, ML, Cote, ML, Funkhouser, E, Peres, LC, Peters, ES, Schwartz, AG, Terry, P, Crankshaw, S, Camacho, F, Wang, F & Moorman, PG 2016, 'Association between body powder use and ovarian cancer: The African American Cancer Epidemiology Study (AACES)', Cancer Epidemiology Biomarkers and Prevention, vol. 25, no. 10, pp. 1411-1417. https://doi.org/10.1158/1055-9965.EPI-15-1281
Schildkraut, Joellen M. ; Abbott, Sarah E. ; Alberg, Anthony J. ; Bandera, Elisa V. ; Barnholtz-Sloan, Jill S. ; Bondy, Melissa L. ; Cote, Michele L. ; Funkhouser, Ellen ; Peres, Lauren C. ; Peters, Edward S. ; Schwartz, Ann G. ; Terry, Paul ; Crankshaw, Sydnee ; Camacho, Fabian ; Wang, Frances ; Moorman, Patricia G. / Association between body powder use and ovarian cancer : The African American Cancer Epidemiology Study (AACES). In: Cancer Epidemiology Biomarkers and Prevention. 2016 ; Vol. 25, No. 10. pp. 1411-1417.
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abstract = "Background: Epidemiologic studies indicate increased ovarian cancer risk among women who use genital powder, but this has not been thoroughly investigated in African American (AA) women, a group with a high prevalence of use. We evaluate the relationship between use of genital powder and nongenital powder in invasive epithelial ovarian cancer (EOC). Methods: Subjects are 584 cases and 745 controls enrolled in the African American Cancer Epidemiology Study (AACES), an ongoing, population-based case-control study of EOC in AA women in 11 geographic locations in the United States. AA controls were frequency matched to cases on residence and age. Logistic regression was used to calculate ORs and 95{\%} confidence intervals (CI) for associations between genital and nongenital powder exposure and EOC risk, controlling for potential confounders. Results: Powder use was common (62.8{\%} of cases and 52.9{\%} of controls). Genital powder was associated with an increased risk of EOC (OR = 1.44; 95{\%} CI, 1.11-1.86) and a dose-response relationship was found for duration of use and number of lifetime applications (P < 0.05). Nongenital use was also associated with EOC risk, particularly among nonserous EOC cases (OR = 2.28; 95{\%} CI, 1.39-3.74). An association between powder use and upper respiratory conditions suggests an enhanced inflammatory response may explain the association between body powder and EOC. Conclusions: In a study of AA women, body powder use was significantly associated with EOC risk. Impact: The results support that body powder is a modifiable risk factor for EOC among AA women.",
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T2 - The African American Cancer Epidemiology Study (AACES)

AU - Schildkraut, Joellen M.

AU - Abbott, Sarah E.

AU - Alberg, Anthony J.

AU - Bandera, Elisa V.

AU - Barnholtz-Sloan, Jill S.

AU - Bondy, Melissa L.

AU - Cote, Michele L.

AU - Funkhouser, Ellen

AU - Peres, Lauren C.

AU - Peters, Edward S.

AU - Schwartz, Ann G.

AU - Terry, Paul

AU - Crankshaw, Sydnee

AU - Camacho, Fabian

AU - Wang, Frances

AU - Moorman, Patricia G.

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N2 - Background: Epidemiologic studies indicate increased ovarian cancer risk among women who use genital powder, but this has not been thoroughly investigated in African American (AA) women, a group with a high prevalence of use. We evaluate the relationship between use of genital powder and nongenital powder in invasive epithelial ovarian cancer (EOC). Methods: Subjects are 584 cases and 745 controls enrolled in the African American Cancer Epidemiology Study (AACES), an ongoing, population-based case-control study of EOC in AA women in 11 geographic locations in the United States. AA controls were frequency matched to cases on residence and age. Logistic regression was used to calculate ORs and 95% confidence intervals (CI) for associations between genital and nongenital powder exposure and EOC risk, controlling for potential confounders. Results: Powder use was common (62.8% of cases and 52.9% of controls). Genital powder was associated with an increased risk of EOC (OR = 1.44; 95% CI, 1.11-1.86) and a dose-response relationship was found for duration of use and number of lifetime applications (P < 0.05). Nongenital use was also associated with EOC risk, particularly among nonserous EOC cases (OR = 2.28; 95% CI, 1.39-3.74). An association between powder use and upper respiratory conditions suggests an enhanced inflammatory response may explain the association between body powder and EOC. Conclusions: In a study of AA women, body powder use was significantly associated with EOC risk. Impact: The results support that body powder is a modifiable risk factor for EOC among AA women.

AB - Background: Epidemiologic studies indicate increased ovarian cancer risk among women who use genital powder, but this has not been thoroughly investigated in African American (AA) women, a group with a high prevalence of use. We evaluate the relationship between use of genital powder and nongenital powder in invasive epithelial ovarian cancer (EOC). Methods: Subjects are 584 cases and 745 controls enrolled in the African American Cancer Epidemiology Study (AACES), an ongoing, population-based case-control study of EOC in AA women in 11 geographic locations in the United States. AA controls were frequency matched to cases on residence and age. Logistic regression was used to calculate ORs and 95% confidence intervals (CI) for associations between genital and nongenital powder exposure and EOC risk, controlling for potential confounders. Results: Powder use was common (62.8% of cases and 52.9% of controls). Genital powder was associated with an increased risk of EOC (OR = 1.44; 95% CI, 1.11-1.86) and a dose-response relationship was found for duration of use and number of lifetime applications (P < 0.05). Nongenital use was also associated with EOC risk, particularly among nonserous EOC cases (OR = 2.28; 95% CI, 1.39-3.74). An association between powder use and upper respiratory conditions suggests an enhanced inflammatory response may explain the association between body powder and EOC. Conclusions: In a study of AA women, body powder use was significantly associated with EOC risk. Impact: The results support that body powder is a modifiable risk factor for EOC among AA women.

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