Association Between Serum Leptin Level and Mortality in Kidney Transplant Recipients

Miklos Z. Molnar, Kristof Nagy, Adam Remport, Abduzhappar Gaipov, Tibor Fülöp, Maria E. Czira, Csaba Kovesdy, Istvan Mucsi, Zoltan Mathe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective Leptin is a hormone made by adipocytes and associated with hypertension, inflammation, and coronary artery disease. Low serum leptin level was associated with higher risk of death in patients with advanced chronic kidney disease. Little is known about the association of serum leptin with outcomes in kidney transplant recipients. Design Prospective prevalent cohort. Setting and Subject We collected sociodemographic and clinical parameters, medical and transplant history, and laboratory data of 979 prevalent kidney transplant recipients. Associations between serum leptin level and death with a functioning graft, all-cause death, and death-censored graft loss over a 6-year follow-up period were examined in survival models. Results Serum leptin levels showed moderate negative correlation with eGFR (R = −0.21, P < .001) and positive correlations with BMI (R = 0.48, P < .001) and C-reactive protein (R = 0.20, P < .001). Each 10 ng/mL higher serum leptin level was associated with 7% lower risk of death with functioning graft (hazard ratio [HR] (95% confidence interval [CI]), 0.93 (0.87-0.99)), and this association persisted after adjustment for confounders: HR (95% CI), 0.90 (0.82-0.99). Similar associations were found with all-cause death as outcome. The association between serum leptin level and risk of graft loss was nonlinear, and only low serum leptin level was associated with higher risk of graft loss. Conclusions In prevalent kidney transplant recipients, lower serum leptin was an independent predictor of death.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalJournal of Renal Nutrition
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2017

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Leptin
Kidney
Mortality
Serum
Transplants
Cause of Death
Confidence Intervals
Transplant Recipients
Chronic Renal Insufficiency
Adipocytes
C-Reactive Protein
Coronary Artery Disease
History
Hormones
Hypertension
Inflammation
Survival

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Nephrology

Cite this

Association Between Serum Leptin Level and Mortality in Kidney Transplant Recipients. / Molnar, Miklos Z.; Nagy, Kristof; Remport, Adam; Gaipov, Abduzhappar; Fülöp, Tibor; Czira, Maria E.; Kovesdy, Csaba; Mucsi, Istvan; Mathe, Zoltan.

In: Journal of Renal Nutrition, Vol. 27, No. 1, 01.01.2017, p. 53-61.

Research output: Contribution to journalArticle

Molnar, Miklos Z. ; Nagy, Kristof ; Remport, Adam ; Gaipov, Abduzhappar ; Fülöp, Tibor ; Czira, Maria E. ; Kovesdy, Csaba ; Mucsi, Istvan ; Mathe, Zoltan. / Association Between Serum Leptin Level and Mortality in Kidney Transplant Recipients. In: Journal of Renal Nutrition. 2017 ; Vol. 27, No. 1. pp. 53-61.
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N2 - Objective Leptin is a hormone made by adipocytes and associated with hypertension, inflammation, and coronary artery disease. Low serum leptin level was associated with higher risk of death in patients with advanced chronic kidney disease. Little is known about the association of serum leptin with outcomes in kidney transplant recipients. Design Prospective prevalent cohort. Setting and Subject We collected sociodemographic and clinical parameters, medical and transplant history, and laboratory data of 979 prevalent kidney transplant recipients. Associations between serum leptin level and death with a functioning graft, all-cause death, and death-censored graft loss over a 6-year follow-up period were examined in survival models. Results Serum leptin levels showed moderate negative correlation with eGFR (R = −0.21, P < .001) and positive correlations with BMI (R = 0.48, P < .001) and C-reactive protein (R = 0.20, P < .001). Each 10 ng/mL higher serum leptin level was associated with 7% lower risk of death with functioning graft (hazard ratio [HR] (95% confidence interval [CI]), 0.93 (0.87-0.99)), and this association persisted after adjustment for confounders: HR (95% CI), 0.90 (0.82-0.99). Similar associations were found with all-cause death as outcome. The association between serum leptin level and risk of graft loss was nonlinear, and only low serum leptin level was associated with higher risk of graft loss. Conclusions In prevalent kidney transplant recipients, lower serum leptin was an independent predictor of death.

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