Association of Abdominal Circumference, Body Mass Index, and Inflammation in Kidney Transplant Recipients

Kristof Nagy, Akos Ujszaszi, Adam Remport, Csaba Kovesdy, Istvan Mucsi, Miklos Z. Molnar, Zoltan Mathe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective Increased abdominal circumference is a marker of obesity, and it is associated with increased mortality in renal transplant recipients. Recent findings suggest that increased visceral fat deposition is a modifier of inflammation. However, little is known about the association of inflammation with abdominal circumference in kidney transplant recipients. Design Cross-sectional. Subject We collected sociodemographic and clinical parameters, medical and transplant history, and laboratory data from 985 prevalent kidney transplant recipients. Abdominal circumference, body mass index (BMI), and inflammatory markers were measured at baseline. Associations of inflammatory markers with abdominal circumference and BMI were examined in unadjusted and adjusted regression models. Results Mean ± standard deviation age was a 51 ± 13 years, 57% were men, and 21% were diabetics. Patients with abdominal circumference above the median had higher BMI and were older (mean ± standard deviation: 23.9 ± 3.6 vs. 30.1 ± 3.9 kg/m2, P < .001; and 48 ± 14 vs. 54 ± 11 years, P < .001). Furthermore, patients with higher abdominal circumference had higher inflammatory parameters: median (interquartile range) C-reactive protein (mg/L): 2.3 (3.9) versus 4.1 (6.2), P < .001; and IL-6 (pg/mL): 1.9 (2.2) versus 2.3 (2.4), P < .001. In multivariable-adjusted linear regression models, higher abdominal circumference showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of abdominal circumference for lnCRP: βabdominal circumference = 0.29, P < .001; and for lnIL-6: βabdominal circumference = 0.09, P = .018). Moreover, in multivariable-adjusted linear regression models, higher BMI showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of BMI for lnCRP: βBMI = 0.24, P < .001; and for white blood cells: βBMI = 0.07, P = .041). Conclusions Abdominal circumference and BMI are independently associated with inflammatory markers in prevalent kidney transplant recipients.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalJournal of Renal Nutrition
Volume26
Issue number5
DOIs
StatePublished - Sep 1 2016

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Body Mass Index
Inflammation
Kidney
Linear Models
Intra-Abdominal Fat
Transplant Recipients
C-Reactive Protein
Interleukin-6
Leukocytes
Obesity
History
Transplants
Mortality

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Nephrology

Cite this

Association of Abdominal Circumference, Body Mass Index, and Inflammation in Kidney Transplant Recipients. / Nagy, Kristof; Ujszaszi, Akos; Remport, Adam; Kovesdy, Csaba; Mucsi, Istvan; Molnar, Miklos Z.; Mathe, Zoltan.

In: Journal of Renal Nutrition, Vol. 26, No. 5, 01.09.2016, p. 325-333.

Research output: Contribution to journalArticle

Nagy, Kristof ; Ujszaszi, Akos ; Remport, Adam ; Kovesdy, Csaba ; Mucsi, Istvan ; Molnar, Miklos Z. ; Mathe, Zoltan. / Association of Abdominal Circumference, Body Mass Index, and Inflammation in Kidney Transplant Recipients. In: Journal of Renal Nutrition. 2016 ; Vol. 26, No. 5. pp. 325-333.
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abstract = "Objective Increased abdominal circumference is a marker of obesity, and it is associated with increased mortality in renal transplant recipients. Recent findings suggest that increased visceral fat deposition is a modifier of inflammation. However, little is known about the association of inflammation with abdominal circumference in kidney transplant recipients. Design Cross-sectional. Subject We collected sociodemographic and clinical parameters, medical and transplant history, and laboratory data from 985 prevalent kidney transplant recipients. Abdominal circumference, body mass index (BMI), and inflammatory markers were measured at baseline. Associations of inflammatory markers with abdominal circumference and BMI were examined in unadjusted and adjusted regression models. Results Mean ± standard deviation age was a 51 ± 13 years, 57{\%} were men, and 21{\%} were diabetics. Patients with abdominal circumference above the median had higher BMI and were older (mean ± standard deviation: 23.9 ± 3.6 vs. 30.1 ± 3.9 kg/m2, P < .001; and 48 ± 14 vs. 54 ± 11 years, P < .001). Furthermore, patients with higher abdominal circumference had higher inflammatory parameters: median (interquartile range) C-reactive protein (mg/L): 2.3 (3.9) versus 4.1 (6.2), P < .001; and IL-6 (pg/mL): 1.9 (2.2) versus 2.3 (2.4), P < .001. In multivariable-adjusted linear regression models, higher abdominal circumference showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of abdominal circumference for lnCRP: βabdominal circumference = 0.29, P < .001; and for lnIL-6: βabdominal circumference = 0.09, P = .018). Moreover, in multivariable-adjusted linear regression models, higher BMI showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of BMI for lnCRP: βBMI = 0.24, P < .001; and for white blood cells: βBMI = 0.07, P = .041). Conclusions Abdominal circumference and BMI are independently associated with inflammatory markers in prevalent kidney transplant recipients.",
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AU - Ujszaszi, Akos

AU - Remport, Adam

AU - Kovesdy, Csaba

AU - Mucsi, Istvan

AU - Molnar, Miklos Z.

AU - Mathe, Zoltan

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N2 - Objective Increased abdominal circumference is a marker of obesity, and it is associated with increased mortality in renal transplant recipients. Recent findings suggest that increased visceral fat deposition is a modifier of inflammation. However, little is known about the association of inflammation with abdominal circumference in kidney transplant recipients. Design Cross-sectional. Subject We collected sociodemographic and clinical parameters, medical and transplant history, and laboratory data from 985 prevalent kidney transplant recipients. Abdominal circumference, body mass index (BMI), and inflammatory markers were measured at baseline. Associations of inflammatory markers with abdominal circumference and BMI were examined in unadjusted and adjusted regression models. Results Mean ± standard deviation age was a 51 ± 13 years, 57% were men, and 21% were diabetics. Patients with abdominal circumference above the median had higher BMI and were older (mean ± standard deviation: 23.9 ± 3.6 vs. 30.1 ± 3.9 kg/m2, P < .001; and 48 ± 14 vs. 54 ± 11 years, P < .001). Furthermore, patients with higher abdominal circumference had higher inflammatory parameters: median (interquartile range) C-reactive protein (mg/L): 2.3 (3.9) versus 4.1 (6.2), P < .001; and IL-6 (pg/mL): 1.9 (2.2) versus 2.3 (2.4), P < .001. In multivariable-adjusted linear regression models, higher abdominal circumference showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of abdominal circumference for lnCRP: βabdominal circumference = 0.29, P < .001; and for lnIL-6: βabdominal circumference = 0.09, P = .018). Moreover, in multivariable-adjusted linear regression models, higher BMI showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of BMI for lnCRP: βBMI = 0.24, P < .001; and for white blood cells: βBMI = 0.07, P = .041). Conclusions Abdominal circumference and BMI are independently associated with inflammatory markers in prevalent kidney transplant recipients.

AB - Objective Increased abdominal circumference is a marker of obesity, and it is associated with increased mortality in renal transplant recipients. Recent findings suggest that increased visceral fat deposition is a modifier of inflammation. However, little is known about the association of inflammation with abdominal circumference in kidney transplant recipients. Design Cross-sectional. Subject We collected sociodemographic and clinical parameters, medical and transplant history, and laboratory data from 985 prevalent kidney transplant recipients. Abdominal circumference, body mass index (BMI), and inflammatory markers were measured at baseline. Associations of inflammatory markers with abdominal circumference and BMI were examined in unadjusted and adjusted regression models. Results Mean ± standard deviation age was a 51 ± 13 years, 57% were men, and 21% were diabetics. Patients with abdominal circumference above the median had higher BMI and were older (mean ± standard deviation: 23.9 ± 3.6 vs. 30.1 ± 3.9 kg/m2, P < .001; and 48 ± 14 vs. 54 ± 11 years, P < .001). Furthermore, patients with higher abdominal circumference had higher inflammatory parameters: median (interquartile range) C-reactive protein (mg/L): 2.3 (3.9) versus 4.1 (6.2), P < .001; and IL-6 (pg/mL): 1.9 (2.2) versus 2.3 (2.4), P < .001. In multivariable-adjusted linear regression models, higher abdominal circumference showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of abdominal circumference for lnCRP: βabdominal circumference = 0.29, P < .001; and for lnIL-6: βabdominal circumference = 0.09, P = .018). Moreover, in multivariable-adjusted linear regression models, higher BMI showed significant linear associations with inflammatory markers (standardized regression coefficients (β) of BMI for lnCRP: βBMI = 0.24, P < .001; and for white blood cells: βBMI = 0.07, P = .041). Conclusions Abdominal circumference and BMI are independently associated with inflammatory markers in prevalent kidney transplant recipients.

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