Association of Ambulatory Blood Pressure Monitoring parameters with the Framingham Stroke Risk Profile

Georgios Tsivgoulis, Maria Pikilidou, Aristeidis H. Katsanos, Kimon Stamatelopoulos, Fotios Michas, Aikaterini Lykka, Christina Zompola, Angeliki Filippatou, Efstathios Boviatsis, Konstantinos Voumvourakis, Nikolaos Zakopoulos, Efstathios Manios

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The Framingham Stroke Risk Profile (FSRP) is a novel and reliable tool for estimating the 10-year probability for incident stroke in stroke-free individuals, while the predictive value of ambulatory blood pressure monitoring (ABPM) for first-ever and recurrent stroke has been well established. We sought to evaluate cross-sectionally the association of ABPM parameters with FSRP score in a large sample of 2343 consecutive stroke-free individuals (mean age: 56.0 ± 12.9, 49.1% male) who underwent 24-hour ABPM. True hypertensives showed significantly higher FSRP (11.2 ± 5.0) compared to the normotensives (8.2 ± 5.0, p < 0.001), while subjects with white coat hypertension also had higher FSRP (10.2 ± 4.7) than normotensives (8.2 ± 5.0, p < 0.001). Compared to dippers that exhibited the lowest FSRP, non-dippers and reverse-dippers exhibited significantly higher FSRP (9.8 ± 4.8 for dippers vs 10.6 ± 5.2 and 11.5 ± 5.0 for non-dippers and reverse-dippers respectively, p ≤ 0.001 for comparisons). In univariate analyses, the ABPM parameters that had the strongest correlation with FSRP were 24-hour (r = 0.440, p < 0.001), daytime (r = 0.435, p < 0.001) and night-time (r = 0.423; p < 0.001) pulse pressure (PP). The best fitting model for predicting FSRP (R2 = 24.6%) on multiple linear regression analyses after adjustment for vascular risk factors not included in FSRP comprised the following parameters in descending order: 24-hour PP (β = 0.349, p < 0.001), daytime SBP variability (β = 0.124, p < 0.001), 24-hour HR variability (β = − 0.091, p < 0.001), mean 24-hour HR (β = − 0.107, p < 0.001), BMI (β = 0.081, p < 0.001) and dipping percentage (β = − 0.063, p = 0.001). 24-hour PP and daytime SBP variability are the two ABPM parameters that were more strongly associated with FSRP-score. Reverse dippers had the highest FSRP among all dipping status profiles.

Original languageEnglish (US)
Pages (from-to)106-111
Number of pages6
JournalJournal of the Neurological Sciences
Volume380
DOIs
StatePublished - Sep 15 2017

Fingerprint

Ambulatory Blood Pressure Monitoring
Stroke
Blood Pressure
White Coat Hypertension

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Association of Ambulatory Blood Pressure Monitoring parameters with the Framingham Stroke Risk Profile. / Tsivgoulis, Georgios; Pikilidou, Maria; Katsanos, Aristeidis H.; Stamatelopoulos, Kimon; Michas, Fotios; Lykka, Aikaterini; Zompola, Christina; Filippatou, Angeliki; Boviatsis, Efstathios; Voumvourakis, Konstantinos; Zakopoulos, Nikolaos; Manios, Efstathios.

In: Journal of the Neurological Sciences, Vol. 380, 15.09.2017, p. 106-111.

Research output: Contribution to journalArticle

Tsivgoulis, G, Pikilidou, M, Katsanos, AH, Stamatelopoulos, K, Michas, F, Lykka, A, Zompola, C, Filippatou, A, Boviatsis, E, Voumvourakis, K, Zakopoulos, N & Manios, E 2017, 'Association of Ambulatory Blood Pressure Monitoring parameters with the Framingham Stroke Risk Profile', Journal of the Neurological Sciences, vol. 380, pp. 106-111. https://doi.org/10.1016/j.jns.2017.07.007
Tsivgoulis, Georgios ; Pikilidou, Maria ; Katsanos, Aristeidis H. ; Stamatelopoulos, Kimon ; Michas, Fotios ; Lykka, Aikaterini ; Zompola, Christina ; Filippatou, Angeliki ; Boviatsis, Efstathios ; Voumvourakis, Konstantinos ; Zakopoulos, Nikolaos ; Manios, Efstathios. / Association of Ambulatory Blood Pressure Monitoring parameters with the Framingham Stroke Risk Profile. In: Journal of the Neurological Sciences. 2017 ; Vol. 380. pp. 106-111.
@article{f0fe8a6381f1485aa9ca68b29a81ea89,
title = "Association of Ambulatory Blood Pressure Monitoring parameters with the Framingham Stroke Risk Profile",
abstract = "The Framingham Stroke Risk Profile (FSRP) is a novel and reliable tool for estimating the 10-year probability for incident stroke in stroke-free individuals, while the predictive value of ambulatory blood pressure monitoring (ABPM) for first-ever and recurrent stroke has been well established. We sought to evaluate cross-sectionally the association of ABPM parameters with FSRP score in a large sample of 2343 consecutive stroke-free individuals (mean age: 56.0 ± 12.9, 49.1{\%} male) who underwent 24-hour ABPM. True hypertensives showed significantly higher FSRP (11.2 ± 5.0) compared to the normotensives (8.2 ± 5.0, p < 0.001), while subjects with white coat hypertension also had higher FSRP (10.2 ± 4.7) than normotensives (8.2 ± 5.0, p < 0.001). Compared to dippers that exhibited the lowest FSRP, non-dippers and reverse-dippers exhibited significantly higher FSRP (9.8 ± 4.8 for dippers vs 10.6 ± 5.2 and 11.5 ± 5.0 for non-dippers and reverse-dippers respectively, p ≤ 0.001 for comparisons). In univariate analyses, the ABPM parameters that had the strongest correlation with FSRP were 24-hour (r = 0.440, p < 0.001), daytime (r = 0.435, p < 0.001) and night-time (r = 0.423; p < 0.001) pulse pressure (PP). The best fitting model for predicting FSRP (R2 = 24.6{\%}) on multiple linear regression analyses after adjustment for vascular risk factors not included in FSRP comprised the following parameters in descending order: 24-hour PP (β = 0.349, p < 0.001), daytime SBP variability (β = 0.124, p < 0.001), 24-hour HR variability (β = − 0.091, p < 0.001), mean 24-hour HR (β = − 0.107, p < 0.001), BMI (β = 0.081, p < 0.001) and dipping percentage (β = − 0.063, p = 0.001). 24-hour PP and daytime SBP variability are the two ABPM parameters that were more strongly associated with FSRP-score. Reverse dippers had the highest FSRP among all dipping status profiles.",
author = "Georgios Tsivgoulis and Maria Pikilidou and Katsanos, {Aristeidis H.} and Kimon Stamatelopoulos and Fotios Michas and Aikaterini Lykka and Christina Zompola and Angeliki Filippatou and Efstathios Boviatsis and Konstantinos Voumvourakis and Nikolaos Zakopoulos and Efstathios Manios",
year = "2017",
month = "9",
day = "15",
doi = "10.1016/j.jns.2017.07.007",
language = "English (US)",
volume = "380",
pages = "106--111",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",

}

TY - JOUR

T1 - Association of Ambulatory Blood Pressure Monitoring parameters with the Framingham Stroke Risk Profile

AU - Tsivgoulis, Georgios

AU - Pikilidou, Maria

AU - Katsanos, Aristeidis H.

AU - Stamatelopoulos, Kimon

AU - Michas, Fotios

AU - Lykka, Aikaterini

AU - Zompola, Christina

AU - Filippatou, Angeliki

AU - Boviatsis, Efstathios

AU - Voumvourakis, Konstantinos

AU - Zakopoulos, Nikolaos

AU - Manios, Efstathios

PY - 2017/9/15

Y1 - 2017/9/15

N2 - The Framingham Stroke Risk Profile (FSRP) is a novel and reliable tool for estimating the 10-year probability for incident stroke in stroke-free individuals, while the predictive value of ambulatory blood pressure monitoring (ABPM) for first-ever and recurrent stroke has been well established. We sought to evaluate cross-sectionally the association of ABPM parameters with FSRP score in a large sample of 2343 consecutive stroke-free individuals (mean age: 56.0 ± 12.9, 49.1% male) who underwent 24-hour ABPM. True hypertensives showed significantly higher FSRP (11.2 ± 5.0) compared to the normotensives (8.2 ± 5.0, p < 0.001), while subjects with white coat hypertension also had higher FSRP (10.2 ± 4.7) than normotensives (8.2 ± 5.0, p < 0.001). Compared to dippers that exhibited the lowest FSRP, non-dippers and reverse-dippers exhibited significantly higher FSRP (9.8 ± 4.8 for dippers vs 10.6 ± 5.2 and 11.5 ± 5.0 for non-dippers and reverse-dippers respectively, p ≤ 0.001 for comparisons). In univariate analyses, the ABPM parameters that had the strongest correlation with FSRP were 24-hour (r = 0.440, p < 0.001), daytime (r = 0.435, p < 0.001) and night-time (r = 0.423; p < 0.001) pulse pressure (PP). The best fitting model for predicting FSRP (R2 = 24.6%) on multiple linear regression analyses after adjustment for vascular risk factors not included in FSRP comprised the following parameters in descending order: 24-hour PP (β = 0.349, p < 0.001), daytime SBP variability (β = 0.124, p < 0.001), 24-hour HR variability (β = − 0.091, p < 0.001), mean 24-hour HR (β = − 0.107, p < 0.001), BMI (β = 0.081, p < 0.001) and dipping percentage (β = − 0.063, p = 0.001). 24-hour PP and daytime SBP variability are the two ABPM parameters that were more strongly associated with FSRP-score. Reverse dippers had the highest FSRP among all dipping status profiles.

AB - The Framingham Stroke Risk Profile (FSRP) is a novel and reliable tool for estimating the 10-year probability for incident stroke in stroke-free individuals, while the predictive value of ambulatory blood pressure monitoring (ABPM) for first-ever and recurrent stroke has been well established. We sought to evaluate cross-sectionally the association of ABPM parameters with FSRP score in a large sample of 2343 consecutive stroke-free individuals (mean age: 56.0 ± 12.9, 49.1% male) who underwent 24-hour ABPM. True hypertensives showed significantly higher FSRP (11.2 ± 5.0) compared to the normotensives (8.2 ± 5.0, p < 0.001), while subjects with white coat hypertension also had higher FSRP (10.2 ± 4.7) than normotensives (8.2 ± 5.0, p < 0.001). Compared to dippers that exhibited the lowest FSRP, non-dippers and reverse-dippers exhibited significantly higher FSRP (9.8 ± 4.8 for dippers vs 10.6 ± 5.2 and 11.5 ± 5.0 for non-dippers and reverse-dippers respectively, p ≤ 0.001 for comparisons). In univariate analyses, the ABPM parameters that had the strongest correlation with FSRP were 24-hour (r = 0.440, p < 0.001), daytime (r = 0.435, p < 0.001) and night-time (r = 0.423; p < 0.001) pulse pressure (PP). The best fitting model for predicting FSRP (R2 = 24.6%) on multiple linear regression analyses after adjustment for vascular risk factors not included in FSRP comprised the following parameters in descending order: 24-hour PP (β = 0.349, p < 0.001), daytime SBP variability (β = 0.124, p < 0.001), 24-hour HR variability (β = − 0.091, p < 0.001), mean 24-hour HR (β = − 0.107, p < 0.001), BMI (β = 0.081, p < 0.001) and dipping percentage (β = − 0.063, p = 0.001). 24-hour PP and daytime SBP variability are the two ABPM parameters that were more strongly associated with FSRP-score. Reverse dippers had the highest FSRP among all dipping status profiles.

UR - http://www.scopus.com/inward/record.url?scp=85025096702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025096702&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2017.07.007

DO - 10.1016/j.jns.2017.07.007

M3 - Article

VL - 380

SP - 106

EP - 111

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

ER -