Association of an intronic variant of the heme oxygenase-1 gene with hypertension in Northern Chinese han population

Li Yun, Liu Xiaoli, Qi Zhao, Wang Laiyuan, Lu Xiangfeng, Shen Chong, Huang Jianfeng, Chen Shufeng, Li Hongfan, Dongfeng Gu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Heme oxygenase was regarded as a regulator of oxidative stress, which was believed to underlie the etiology of hypertension. To assess the effect of its encoded genes (HMOX1 and HMOX2) on hypertension, we designed a case-control study in 503 cases and 490 controls. The results indicated that the rs9607267 of the HMOX1 gene was significantly associated with essential hypertension (EH) and the Hap3(T-C-G) of the HMOX1 gene was also significantly associated with the risk of EH. No association was observed between the HMOX2 gene and EH. The multifactor-dimensionality reduction analyses results did not show any interaction between the HMOX1 and HMOX2 genes underlying the development of hypertension.

Original languageEnglish (US)
Pages (from-to)534-543
Number of pages10
JournalClinical and Experimental Hypertension
Volume31
Issue number7
DOIs
StatePublished - Nov 1 2009
Externally publishedYes

Fingerprint

Heme Oxygenase-1
Hypertension
Population
Genes
Multifactor Dimensionality Reduction
Heme Oxygenase (Decyclizing)
Case-Control Studies
Oxidative Stress
Essential Hypertension

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

Cite this

Association of an intronic variant of the heme oxygenase-1 gene with hypertension in Northern Chinese han population. / Yun, Li; Xiaoli, Liu; Zhao, Qi; Laiyuan, Wang; Xiangfeng, Lu; Chong, Shen; Jianfeng, Huang; Shufeng, Chen; Hongfan, Li; Gu, Dongfeng.

In: Clinical and Experimental Hypertension, Vol. 31, No. 7, 01.11.2009, p. 534-543.

Research output: Contribution to journalArticle

Yun, L, Xiaoli, L, Zhao, Q, Laiyuan, W, Xiangfeng, L, Chong, S, Jianfeng, H, Shufeng, C, Hongfan, L & Gu, D 2009, 'Association of an intronic variant of the heme oxygenase-1 gene with hypertension in Northern Chinese han population', Clinical and Experimental Hypertension, vol. 31, no. 7, pp. 534-543. https://doi.org/10.3109/10641960902825461
Yun, Li ; Xiaoli, Liu ; Zhao, Qi ; Laiyuan, Wang ; Xiangfeng, Lu ; Chong, Shen ; Jianfeng, Huang ; Shufeng, Chen ; Hongfan, Li ; Gu, Dongfeng. / Association of an intronic variant of the heme oxygenase-1 gene with hypertension in Northern Chinese han population. In: Clinical and Experimental Hypertension. 2009 ; Vol. 31, No. 7. pp. 534-543.
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