Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight loss

John B. Kostis, Alan C. Wilson, W. Craig Hooper, Kathryn W. Harrison, Claire S. Philipp, Lawrence J. Appel, Mark A. Espeland, Steven Folmar, Karen Johnson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Weight loss and sodium reduction are useful nonpharmacologic interventions in the management of hypertension. Salt sensitivity - the degree of blood pressure change in response to a change in sodium load - has been extensively explored. However, the determinants of the extent of blood pressure change after weight reduction have not been evaluated. Methods: We studied the relationship of the angiotensin-converting enzyme insertion-deletion (ACE I/D) polymorphism to blood pressure change after weight loss in the Trial Of Nonpharmacologic interventions in the Elderly (TONE). We focused on the 86 overweight white hypertensive TONE participants who were randomized to weight loss only. Results: A similar weight reduction was observed across all ACE genotypes, whereas a significantly greater decrease in blood pressure after weight loss was seen among participants with the DD genotype. In addition, DD participants had a higher probability of remaining normotensive for the duration of the trial. Conclusions: The DD genotype may be associated with higher "weight sensitivity" in overweight white hypertensive persons, potentially through reduced activity of the renin-angiotensin and sympathetic systems after weight loss.

Original languageEnglish (US)
Pages (from-to)625-629
Number of pages5
JournalAmerican Heart Journal
Volume144
Issue number4
DOIs
StatePublished - Oct 1 2002

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Peptidyl-Dipeptidase A
Weight Loss
Genotype
Blood Pressure
Sodium
Renin-Angiotensin System
Salts
Hypertension
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight loss. / Kostis, John B.; Wilson, Alan C.; Hooper, W. Craig; Harrison, Kathryn W.; Philipp, Claire S.; Appel, Lawrence J.; Espeland, Mark A.; Folmar, Steven; Johnson, Karen.

In: American Heart Journal, Vol. 144, No. 4, 01.10.2002, p. 625-629.

Research output: Contribution to journalArticle

Kostis, JB, Wilson, AC, Hooper, WC, Harrison, KW, Philipp, CS, Appel, LJ, Espeland, MA, Folmar, S & Johnson, K 2002, 'Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight loss', American Heart Journal, vol. 144, no. 4, pp. 625-629. https://doi.org/10.1016/S0002-8703(02)00132-1
Kostis, John B. ; Wilson, Alan C. ; Hooper, W. Craig ; Harrison, Kathryn W. ; Philipp, Claire S. ; Appel, Lawrence J. ; Espeland, Mark A. ; Folmar, Steven ; Johnson, Karen. / Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight loss. In: American Heart Journal. 2002 ; Vol. 144, No. 4. pp. 625-629.
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