Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes

Thomas R. Terrell, Roberd Bostick, Gary L. Rogers, Michael A. Langston, Jeffery Barth, Ellen Bennett, Richard Sloane, Leslie Galloway, Robert C. Cantu, Fabian Mihelic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The management of sports concussion and an understanding of its risk factors are major foci i. The literature on athletic injury. Althoug. There is known influence of some genetic polymorphisms (GPs), such as APOE an. The APOE promoter, on traumatic brain injury (TBI) outcome in non-athletic populations, very little work has focused o. The rol. These GPs may play in sports concussion. We completed a large (n=3274) multi-center prospective cohort study of college athletes to study possible associations between various GPs and prospectively occurring sports concussion. We found no significant relationship betwee. The APOE e4 allele. The APOE G-219T promoter. The tau exon 6 Ser53pro o. The tau His47Tyr GPs on prospective concussion. Additional study of other GPs and haplotype combinations is a next logical step i. The search for genetic predisposition to sports-related concussion.

Original languageEnglish (US)
Title of host publicationProceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference
Subtitle of host publicationCollaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479941599
DOIs
StatePublished - Jul 29 2014
Event5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2014 - Oak Ridge, United States
Duration: May 6 2014May 8 2014

Publication series

NameProceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014

Other

Other5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2014
CountryUnited States
CityOak Ridge
Period5/6/145/8/14

Fingerprint

Genetic Polymorphisms
Polymorphism
Athletes
Sports
Cohort Studies
Prospective Studies
Athletic Injuries
Genetic Predisposition to Disease
Haplotypes
Exons
Brain
Alleles
Population

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biomedical Engineering

Cite this

Terrell, T. R., Bostick, R., Rogers, G. L., Langston, M. A., Barth, J., Bennett, E., ... Mihelic, F. (2014). Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes. In Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014 [6867745] (Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BSEC.2014.6867745

Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes. / Terrell, Thomas R.; Bostick, Roberd; Rogers, Gary L.; Langston, Michael A.; Barth, Jeffery; Bennett, Ellen; Sloane, Richard; Galloway, Leslie; Cantu, Robert C.; Mihelic, Fabian.

Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. 6867745 (Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Terrell, TR, Bostick, R, Rogers, GL, Langston, MA, Barth, J, Bennett, E, Sloane, R, Galloway, L, Cantu, RC & Mihelic, F 2014, Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes. in Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014., 6867745, Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014, Institute of Electrical and Electronics Engineers Inc., 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2014, Oak Ridge, United States, 5/6/14. https://doi.org/10.1109/BSEC.2014.6867745
Terrell TR, Bostick R, Rogers GL, Langston MA, Barth J, Bennett E et al. Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes. In Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014. Institute of Electrical and Electronics Engineers Inc. 2014. 6867745. (Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014). https://doi.org/10.1109/BSEC.2014.6867745
Terrell, Thomas R. ; Bostick, Roberd ; Rogers, Gary L. ; Langston, Michael A. ; Barth, Jeffery ; Bennett, Ellen ; Sloane, Richard ; Galloway, Leslie ; Cantu, Robert C. ; Mihelic, Fabian. / Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes. Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. (Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014).
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