Association of depression and antidepressant use with mortality in a large cohort of patients with nondialysis-dependent CKD

Rasheed A. Balogun, Emaad M. Abdel-Rahman, Seki A. Balogun, Evan H. Lott, Jun Ling Lu, Sandra M. Malakauskas, Jennie Z. Ma, Kamyar Kalantar-Zadeh, Csaba Kovesdy

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Abstract

Background and objectives Depression is common and is associated with higher mortality in patients with ESRD or CKD (stage 5). Less information is available on earlier stages of CKD. This study aimed to determine the prevalence of depression and any association with all-cause mortality in patients with varying severity of nondialysis-dependent CKD. Design, setting, participants, & measurements This is a retrospective study of a national cohort of 598,153 US veterans with nondialysis-dependent CKD stages 1-5 followed for a median of 4.7 years in the US Department of Veterans Affairs Health System. Diagnosis of depression was established as a result of systematic screening and administration of antidepressants. Association of depression with all-cause mortality overall and stratified by CKD stages were examined with the Kaplan-Meier method and in Cox models. Results There were 179,441 patients (30%) with a diagnosis of depression. Over median follow-up of 4.7 years, depression was associated with significantly higher age-adjusted mortality overall (hazard ratio, 1.55; 95% confidence interval, 1.54-1.57; P<0.001). Sequential adjustments for sociodemographic characteristics and especially for comorbid conditions attenuated this association, which nevertheless remained significant (hazard ratio, 1.25; 95% confidence interval, 1.23-1.26). Conclusions In this large cohort of predominantly elderly male patients with CKD, prevalence of depression and antidepressant use is high (30%) and is associated with significantly higher all-cause mortality independent of comorbid conditions.

Original languageEnglish (US)
Pages (from-to)1793-1800
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume7
Issue number11
DOIs
StatePublished - Nov 7 2012

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Antidepressive Agents
Mortality
Confidence Intervals
Veterans Health
Veterans
Proportional Hazards Models
Chronic Kidney Failure
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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Association of depression and antidepressant use with mortality in a large cohort of patients with nondialysis-dependent CKD. / Balogun, Rasheed A.; Abdel-Rahman, Emaad M.; Balogun, Seki A.; Lott, Evan H.; Lu, Jun Ling; Malakauskas, Sandra M.; Ma, Jennie Z.; Kalantar-Zadeh, Kamyar; Kovesdy, Csaba.

In: Clinical Journal of the American Society of Nephrology, Vol. 7, No. 11, 07.11.2012, p. 1793-1800.

Research output: Contribution to journalArticle

Balogun, Rasheed A. ; Abdel-Rahman, Emaad M. ; Balogun, Seki A. ; Lott, Evan H. ; Lu, Jun Ling ; Malakauskas, Sandra M. ; Ma, Jennie Z. ; Kalantar-Zadeh, Kamyar ; Kovesdy, Csaba. / Association of depression and antidepressant use with mortality in a large cohort of patients with nondialysis-dependent CKD. In: Clinical Journal of the American Society of Nephrology. 2012 ; Vol. 7, No. 11. pp. 1793-1800.
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abstract = "Background and objectives Depression is common and is associated with higher mortality in patients with ESRD or CKD (stage 5). Less information is available on earlier stages of CKD. This study aimed to determine the prevalence of depression and any association with all-cause mortality in patients with varying severity of nondialysis-dependent CKD. Design, setting, participants, & measurements This is a retrospective study of a national cohort of 598,153 US veterans with nondialysis-dependent CKD stages 1-5 followed for a median of 4.7 years in the US Department of Veterans Affairs Health System. Diagnosis of depression was established as a result of systematic screening and administration of antidepressants. Association of depression with all-cause mortality overall and stratified by CKD stages were examined with the Kaplan-Meier method and in Cox models. Results There were 179,441 patients (30{\%}) with a diagnosis of depression. Over median follow-up of 4.7 years, depression was associated with significantly higher age-adjusted mortality overall (hazard ratio, 1.55; 95{\%} confidence interval, 1.54-1.57; P<0.001). Sequential adjustments for sociodemographic characteristics and especially for comorbid conditions attenuated this association, which nevertheless remained significant (hazard ratio, 1.25; 95{\%} confidence interval, 1.23-1.26). Conclusions In this large cohort of predominantly elderly male patients with CKD, prevalence of depression and antidepressant use is high (30{\%}) and is associated with significantly higher all-cause mortality independent of comorbid conditions.",
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AU - Abdel-Rahman, Emaad M.

AU - Balogun, Seki A.

AU - Lott, Evan H.

AU - Lu, Jun Ling

AU - Malakauskas, Sandra M.

AU - Ma, Jennie Z.

AU - Kalantar-Zadeh, Kamyar

AU - Kovesdy, Csaba

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N2 - Background and objectives Depression is common and is associated with higher mortality in patients with ESRD or CKD (stage 5). Less information is available on earlier stages of CKD. This study aimed to determine the prevalence of depression and any association with all-cause mortality in patients with varying severity of nondialysis-dependent CKD. Design, setting, participants, & measurements This is a retrospective study of a national cohort of 598,153 US veterans with nondialysis-dependent CKD stages 1-5 followed for a median of 4.7 years in the US Department of Veterans Affairs Health System. Diagnosis of depression was established as a result of systematic screening and administration of antidepressants. Association of depression with all-cause mortality overall and stratified by CKD stages were examined with the Kaplan-Meier method and in Cox models. Results There were 179,441 patients (30%) with a diagnosis of depression. Over median follow-up of 4.7 years, depression was associated with significantly higher age-adjusted mortality overall (hazard ratio, 1.55; 95% confidence interval, 1.54-1.57; P<0.001). Sequential adjustments for sociodemographic characteristics and especially for comorbid conditions attenuated this association, which nevertheless remained significant (hazard ratio, 1.25; 95% confidence interval, 1.23-1.26). Conclusions In this large cohort of predominantly elderly male patients with CKD, prevalence of depression and antidepressant use is high (30%) and is associated with significantly higher all-cause mortality independent of comorbid conditions.

AB - Background and objectives Depression is common and is associated with higher mortality in patients with ESRD or CKD (stage 5). Less information is available on earlier stages of CKD. This study aimed to determine the prevalence of depression and any association with all-cause mortality in patients with varying severity of nondialysis-dependent CKD. Design, setting, participants, & measurements This is a retrospective study of a national cohort of 598,153 US veterans with nondialysis-dependent CKD stages 1-5 followed for a median of 4.7 years in the US Department of Veterans Affairs Health System. Diagnosis of depression was established as a result of systematic screening and administration of antidepressants. Association of depression with all-cause mortality overall and stratified by CKD stages were examined with the Kaplan-Meier method and in Cox models. Results There were 179,441 patients (30%) with a diagnosis of depression. Over median follow-up of 4.7 years, depression was associated with significantly higher age-adjusted mortality overall (hazard ratio, 1.55; 95% confidence interval, 1.54-1.57; P<0.001). Sequential adjustments for sociodemographic characteristics and especially for comorbid conditions attenuated this association, which nevertheless remained significant (hazard ratio, 1.25; 95% confidence interval, 1.23-1.26). Conclusions In this large cohort of predominantly elderly male patients with CKD, prevalence of depression and antidepressant use is high (30%) and is associated with significantly higher all-cause mortality independent of comorbid conditions.

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