Association of hearing impairment with brain volume changes in older adults

F. R. Lin, L. Ferrucci, Y. An, J. O. Goh, Jimit Doshi, E. Metter, C. Davatzikos, M. A. Kraut, S. M. Resnick

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Hearing impairment in older adults is independently associated in longitudinal studies with accelerated cognitive decline and incident dementia, and in cross-sectional studies, with reduced volumes in the auditory cortex. Whether peripheral hearing impairment is associated with accelerated rates of brain atrophy is unclear. We analyzed brain volume measurements from magnetic resonance brain scans of individuals with normal hearing versus hearing impairment (speech-frequency pure tone average. >. 25. dB) followed in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging for a mean of 6.4. years after the baseline scan (n = 126, age 56-86. years). Brain volume measurements were performed with semi-automated region-of-interest (ROI) algorithms, and brain volume trajectories were analyzed with mixed-effect regression models adjusted for demographic and cardiovascular factors. We found that individuals with hearing impairment (n = 51) compared to those with normal hearing (n = 75) had accelerated volume declines in whole brain and regional volumes in the right temporal lobe (superior, middle, and inferior temporal gyri, parahippocampus, p. <.05). These results were robust to adjustment for multiple confounders and were consistent with voxel-based analyses, which also implicated right greater than left temporal regions. These findings demonstrate that peripheral hearing impairment is independently associated with accelerated brain atrophy in whole brain and regional volumes concentrated in the right temporal lobe. Further studies investigating the mechanistic basis of the observed associations are needed.

Original languageEnglish (US)
Pages (from-to)84-92
Number of pages9
JournalNeuroImage
Volume90
DOIs
StatePublished - Apr 15 2014
Externally publishedYes

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Hearing Loss
Brain
Temporal Lobe
Hearing
Atrophy
Longitudinal Studies
Baltimore
Auditory Cortex
Neuroimaging
Dementia
Magnetic Resonance Spectroscopy
Cross-Sectional Studies
Demography

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Lin, F. R., Ferrucci, L., An, Y., Goh, J. O., Doshi, J., Metter, E., ... Resnick, S. M. (2014). Association of hearing impairment with brain volume changes in older adults. NeuroImage, 90, 84-92. https://doi.org/10.1016/j.neuroimage.2013.12.059

Association of hearing impairment with brain volume changes in older adults. / Lin, F. R.; Ferrucci, L.; An, Y.; Goh, J. O.; Doshi, Jimit; Metter, E.; Davatzikos, C.; Kraut, M. A.; Resnick, S. M.

In: NeuroImage, Vol. 90, 15.04.2014, p. 84-92.

Research output: Contribution to journalArticle

Lin, FR, Ferrucci, L, An, Y, Goh, JO, Doshi, J, Metter, E, Davatzikos, C, Kraut, MA & Resnick, SM 2014, 'Association of hearing impairment with brain volume changes in older adults', NeuroImage, vol. 90, pp. 84-92. https://doi.org/10.1016/j.neuroimage.2013.12.059
Lin, F. R. ; Ferrucci, L. ; An, Y. ; Goh, J. O. ; Doshi, Jimit ; Metter, E. ; Davatzikos, C. ; Kraut, M. A. ; Resnick, S. M. / Association of hearing impairment with brain volume changes in older adults. In: NeuroImage. 2014 ; Vol. 90. pp. 84-92.
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