Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls

Sulin Cheng, Frances Tylavsky, Heikki Kröger, Merja Kärkkäinen, Arja Lyytikainen, Arvo Koistinen, Anitta Mahonen, Markku Alen, Jussi Halleen, Kalervo Väänänen, Christel Lamberg-Allardt

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Abstract

Background: Very few studies have evaluated both parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] and their effects on bone mass in children. Objective: We studied the associations of serum 25(OH)D and intact PTH (iPTH) with bone mineral content (BMC) and bone mineral density (BMD) at different bone sites and the relation between serum 25(OH)D and iPTH in early pubertal and prepubertal Finnish girls. Design: The subjects were 10-12-y-old girls (n = 193) at Tanner stage 1 or 2. who reported a mean (±SD) dietary calcium intake of 733 ± 288 mg/d. 25(OH)D, iPTH, tartrate-resistant acid phosphatase 5b (TRAP 5b), urinary calcium excretion, BMC, arcal BMD, and volumetric BMD were assessed by using different methods. Results: Thirty-two percent of the girls were vitamin D deficient [serum 25(OH)D ≤ 25 nmol/L], and 46% of the girls had an insufficient concentration (26-40 nmol/L). iPTH and TRAP 5b concentrations were significantly higher in the deficient group than in the insufficient and sufficient groups [iPTH: 43.9 ± 15.7 compared with 38.6 ± 11.2 pg/L (P = 0.049) and 32.7 ± 12.1 pg/L (P < 0.001), respectively; TRAP 5b: 12.2 ± 2.9 compared with 11.0 ± 2.8 U/L (P = 0.009) and 10.9 ± 1.9 U/L (P = 0.006), respectively]. The girls in the deficient group also had significantly lower cortical volumetric BMD of the distal radius (P < 0.001) and tibia shaft (P = 0.002). High iPTH concentrations were also associated with low total-body apparent mineral density and urinary calcium excretion (P < 0.007). Conclusions: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.

Original languageEnglish (US)
Pages (from-to)485-492
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume78
Issue number3
StatePublished - Sep 1 2003

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Parathyroid Hormone
Bone Density
Vitamin D
Bone and Bones
Serum
Calcium
Dietary Calcium
Secondary Hyperparathyroidism
Bone Resorption
25-hydroxyvitamin D
Cortical Bone
Tibia
Minerals
Tartrate-Resistant Acid Phosphatase

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls. / Cheng, Sulin; Tylavsky, Frances; Kröger, Heikki; Kärkkäinen, Merja; Lyytikainen, Arja; Koistinen, Arvo; Mahonen, Anitta; Alen, Markku; Halleen, Jussi; Väänänen, Kalervo; Lamberg-Allardt, Christel.

In: American Journal of Clinical Nutrition, Vol. 78, No. 3, 01.09.2003, p. 485-492.

Research output: Contribution to journalArticle

Cheng, S, Tylavsky, F, Kröger, H, Kärkkäinen, M, Lyytikainen, A, Koistinen, A, Mahonen, A, Alen, M, Halleen, J, Väänänen, K & Lamberg-Allardt, C 2003, 'Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls', American Journal of Clinical Nutrition, vol. 78, no. 3, pp. 485-492.
Cheng, Sulin ; Tylavsky, Frances ; Kröger, Heikki ; Kärkkäinen, Merja ; Lyytikainen, Arja ; Koistinen, Arvo ; Mahonen, Anitta ; Alen, Markku ; Halleen, Jussi ; Väänänen, Kalervo ; Lamberg-Allardt, Christel. / Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls. In: American Journal of Clinical Nutrition. 2003 ; Vol. 78, No. 3. pp. 485-492.
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abstract = "Background: Very few studies have evaluated both parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] and their effects on bone mass in children. Objective: We studied the associations of serum 25(OH)D and intact PTH (iPTH) with bone mineral content (BMC) and bone mineral density (BMD) at different bone sites and the relation between serum 25(OH)D and iPTH in early pubertal and prepubertal Finnish girls. Design: The subjects were 10-12-y-old girls (n = 193) at Tanner stage 1 or 2. who reported a mean (±SD) dietary calcium intake of 733 ± 288 mg/d. 25(OH)D, iPTH, tartrate-resistant acid phosphatase 5b (TRAP 5b), urinary calcium excretion, BMC, arcal BMD, and volumetric BMD were assessed by using different methods. Results: Thirty-two percent of the girls were vitamin D deficient [serum 25(OH)D ≤ 25 nmol/L], and 46{\%} of the girls had an insufficient concentration (26-40 nmol/L). iPTH and TRAP 5b concentrations were significantly higher in the deficient group than in the insufficient and sufficient groups [iPTH: 43.9 ± 15.7 compared with 38.6 ± 11.2 pg/L (P = 0.049) and 32.7 ± 12.1 pg/L (P < 0.001), respectively; TRAP 5b: 12.2 ± 2.9 compared with 11.0 ± 2.8 U/L (P = 0.009) and 10.9 ± 1.9 U/L (P = 0.006), respectively]. The girls in the deficient group also had significantly lower cortical volumetric BMD of the distal radius (P < 0.001) and tibia shaft (P = 0.002). High iPTH concentrations were also associated with low total-body apparent mineral density and urinary calcium excretion (P < 0.007). Conclusions: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.",
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T1 - Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls

AU - Cheng, Sulin

AU - Tylavsky, Frances

AU - Kröger, Heikki

AU - Kärkkäinen, Merja

AU - Lyytikainen, Arja

AU - Koistinen, Arvo

AU - Mahonen, Anitta

AU - Alen, Markku

AU - Halleen, Jussi

AU - Väänänen, Kalervo

AU - Lamberg-Allardt, Christel

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Background: Very few studies have evaluated both parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] and their effects on bone mass in children. Objective: We studied the associations of serum 25(OH)D and intact PTH (iPTH) with bone mineral content (BMC) and bone mineral density (BMD) at different bone sites and the relation between serum 25(OH)D and iPTH in early pubertal and prepubertal Finnish girls. Design: The subjects were 10-12-y-old girls (n = 193) at Tanner stage 1 or 2. who reported a mean (±SD) dietary calcium intake of 733 ± 288 mg/d. 25(OH)D, iPTH, tartrate-resistant acid phosphatase 5b (TRAP 5b), urinary calcium excretion, BMC, arcal BMD, and volumetric BMD were assessed by using different methods. Results: Thirty-two percent of the girls were vitamin D deficient [serum 25(OH)D ≤ 25 nmol/L], and 46% of the girls had an insufficient concentration (26-40 nmol/L). iPTH and TRAP 5b concentrations were significantly higher in the deficient group than in the insufficient and sufficient groups [iPTH: 43.9 ± 15.7 compared with 38.6 ± 11.2 pg/L (P = 0.049) and 32.7 ± 12.1 pg/L (P < 0.001), respectively; TRAP 5b: 12.2 ± 2.9 compared with 11.0 ± 2.8 U/L (P = 0.009) and 10.9 ± 1.9 U/L (P = 0.006), respectively]. The girls in the deficient group also had significantly lower cortical volumetric BMD of the distal radius (P < 0.001) and tibia shaft (P = 0.002). High iPTH concentrations were also associated with low total-body apparent mineral density and urinary calcium excretion (P < 0.007). Conclusions: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.

AB - Background: Very few studies have evaluated both parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] and their effects on bone mass in children. Objective: We studied the associations of serum 25(OH)D and intact PTH (iPTH) with bone mineral content (BMC) and bone mineral density (BMD) at different bone sites and the relation between serum 25(OH)D and iPTH in early pubertal and prepubertal Finnish girls. Design: The subjects were 10-12-y-old girls (n = 193) at Tanner stage 1 or 2. who reported a mean (±SD) dietary calcium intake of 733 ± 288 mg/d. 25(OH)D, iPTH, tartrate-resistant acid phosphatase 5b (TRAP 5b), urinary calcium excretion, BMC, arcal BMD, and volumetric BMD were assessed by using different methods. Results: Thirty-two percent of the girls were vitamin D deficient [serum 25(OH)D ≤ 25 nmol/L], and 46% of the girls had an insufficient concentration (26-40 nmol/L). iPTH and TRAP 5b concentrations were significantly higher in the deficient group than in the insufficient and sufficient groups [iPTH: 43.9 ± 15.7 compared with 38.6 ± 11.2 pg/L (P = 0.049) and 32.7 ± 12.1 pg/L (P < 0.001), respectively; TRAP 5b: 12.2 ± 2.9 compared with 11.0 ± 2.8 U/L (P = 0.009) and 10.9 ± 1.9 U/L (P = 0.006), respectively]. The girls in the deficient group also had significantly lower cortical volumetric BMD of the distal radius (P < 0.001) and tibia shaft (P = 0.002). High iPTH concentrations were also associated with low total-body apparent mineral density and urinary calcium excretion (P < 0.007). Conclusions: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.

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