Association of pre-kidney transplant markers of mineral and bone disorder with post-transplant outcomes

Miklos Z. Molnar, Csaba Kovesdy, Istvan Mucsi, Isidro B. Salusky, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background and objectives Mineral and bone disorders (MBDs) are common in long-term dialysis patients and are risk factors for unfavorable outcomes. The associations between pretransplant levels of MBD surrogates and outcomes after kidney transplantation are not clear. Design, setting, participants, & measurements Data from the Scientific Registry of Transplant Recipients up to June 2007 were linked to the 5-year (July 2001-June 2006) cohort of a large dialysis organization in the United States. All dialysis patients who received a kidney transplant during this period were identified and divided into groups according to increments of pretransplant MBD markers. Unadjusted and multivariate adjusted predictors of transplant outcomes were examined. Results The 11,776 patients were aged 47±14 years and 39% were women. Compared with recipients with pretransplant time-averaged serum alkaline phosphatase of 80-120 U/L, recipients with pretransplant serum alkaline phosphatase of 120-160 and ≥160 U/L had 49% and 64% higher graft failure censored all-cause mortality in multivariable adjusted models. There was no significant association between time-averaged serum alkaline phosphatase categories and risk of death censored graft failure, delayed graft function (DGF), or acute rejection (AR). Compared with recipients with pretransplant time-averaged serum parathyroid hormone (PTH) levels of 150-300 pg/ml, there was no significant association with graft censored death among recipients with pretransplant serum PTH ≥800 pg/ml. In addition, the risk of graft failure, DGF, and AR did not show any association with time-averaged serum intact PTH level. There was no significant association between time-averaged serum calcium categories and risk of graft failure censored death, DGF, and AR. Conclusions In this cohort, hemodialysis patients with pretransplant serum alkaline phosphatase >120 U/L have unfavorable post-transplant mortality, whereas there was no association between serum PTH and serum calcium levels and post-transplant outcomes.

Original languageEnglish (US)
Pages (from-to)1859-1871
Number of pages13
JournalClinical Journal of the American Society of Nephrology
Volume7
Issue number11
DOIs
StatePublished - Nov 7 2012

Fingerprint

Minerals
Transplants
Kidney
Bone and Bones
Serum
Delayed Graft Function
Parathyroid Hormone
Alkaline Phosphatase
Dialysis
Calcium
Mortality
Kidney Transplantation
Registries
Renal Dialysis
Organizations

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Association of pre-kidney transplant markers of mineral and bone disorder with post-transplant outcomes. / Molnar, Miklos Z.; Kovesdy, Csaba; Mucsi, Istvan; Salusky, Isidro B.; Kalantar-Zadeh, Kamyar.

In: Clinical Journal of the American Society of Nephrology, Vol. 7, No. 11, 07.11.2012, p. 1859-1871.

Research output: Contribution to journalArticle

Molnar, Miklos Z. ; Kovesdy, Csaba ; Mucsi, Istvan ; Salusky, Isidro B. ; Kalantar-Zadeh, Kamyar. / Association of pre-kidney transplant markers of mineral and bone disorder with post-transplant outcomes. In: Clinical Journal of the American Society of Nephrology. 2012 ; Vol. 7, No. 11. pp. 1859-1871.
@article{0aa7f000db544dc6b4824126494a62f7,
title = "Association of pre-kidney transplant markers of mineral and bone disorder with post-transplant outcomes",
abstract = "Background and objectives Mineral and bone disorders (MBDs) are common in long-term dialysis patients and are risk factors for unfavorable outcomes. The associations between pretransplant levels of MBD surrogates and outcomes after kidney transplantation are not clear. Design, setting, participants, & measurements Data from the Scientific Registry of Transplant Recipients up to June 2007 were linked to the 5-year (July 2001-June 2006) cohort of a large dialysis organization in the United States. All dialysis patients who received a kidney transplant during this period were identified and divided into groups according to increments of pretransplant MBD markers. Unadjusted and multivariate adjusted predictors of transplant outcomes were examined. Results The 11,776 patients were aged 47±14 years and 39{\%} were women. Compared with recipients with pretransplant time-averaged serum alkaline phosphatase of 80-120 U/L, recipients with pretransplant serum alkaline phosphatase of 120-160 and ≥160 U/L had 49{\%} and 64{\%} higher graft failure censored all-cause mortality in multivariable adjusted models. There was no significant association between time-averaged serum alkaline phosphatase categories and risk of death censored graft failure, delayed graft function (DGF), or acute rejection (AR). Compared with recipients with pretransplant time-averaged serum parathyroid hormone (PTH) levels of 150-300 pg/ml, there was no significant association with graft censored death among recipients with pretransplant serum PTH ≥800 pg/ml. In addition, the risk of graft failure, DGF, and AR did not show any association with time-averaged serum intact PTH level. There was no significant association between time-averaged serum calcium categories and risk of graft failure censored death, DGF, and AR. Conclusions In this cohort, hemodialysis patients with pretransplant serum alkaline phosphatase >120 U/L have unfavorable post-transplant mortality, whereas there was no association between serum PTH and serum calcium levels and post-transplant outcomes.",
author = "Molnar, {Miklos Z.} and Csaba Kovesdy and Istvan Mucsi and Salusky, {Isidro B.} and Kamyar Kalantar-Zadeh",
year = "2012",
month = "11",
day = "7",
doi = "10.2215/CJN.01910212",
language = "English (US)",
volume = "7",
pages = "1859--1871",
journal = "Clinical journal of the American Society of Nephrology : CJASN",
issn = "1555-9041",
publisher = "American Society of Nephrology",
number = "11",

}

TY - JOUR

T1 - Association of pre-kidney transplant markers of mineral and bone disorder with post-transplant outcomes

AU - Molnar, Miklos Z.

AU - Kovesdy, Csaba

AU - Mucsi, Istvan

AU - Salusky, Isidro B.

AU - Kalantar-Zadeh, Kamyar

PY - 2012/11/7

Y1 - 2012/11/7

N2 - Background and objectives Mineral and bone disorders (MBDs) are common in long-term dialysis patients and are risk factors for unfavorable outcomes. The associations between pretransplant levels of MBD surrogates and outcomes after kidney transplantation are not clear. Design, setting, participants, & measurements Data from the Scientific Registry of Transplant Recipients up to June 2007 were linked to the 5-year (July 2001-June 2006) cohort of a large dialysis organization in the United States. All dialysis patients who received a kidney transplant during this period were identified and divided into groups according to increments of pretransplant MBD markers. Unadjusted and multivariate adjusted predictors of transplant outcomes were examined. Results The 11,776 patients were aged 47±14 years and 39% were women. Compared with recipients with pretransplant time-averaged serum alkaline phosphatase of 80-120 U/L, recipients with pretransplant serum alkaline phosphatase of 120-160 and ≥160 U/L had 49% and 64% higher graft failure censored all-cause mortality in multivariable adjusted models. There was no significant association between time-averaged serum alkaline phosphatase categories and risk of death censored graft failure, delayed graft function (DGF), or acute rejection (AR). Compared with recipients with pretransplant time-averaged serum parathyroid hormone (PTH) levels of 150-300 pg/ml, there was no significant association with graft censored death among recipients with pretransplant serum PTH ≥800 pg/ml. In addition, the risk of graft failure, DGF, and AR did not show any association with time-averaged serum intact PTH level. There was no significant association between time-averaged serum calcium categories and risk of graft failure censored death, DGF, and AR. Conclusions In this cohort, hemodialysis patients with pretransplant serum alkaline phosphatase >120 U/L have unfavorable post-transplant mortality, whereas there was no association between serum PTH and serum calcium levels and post-transplant outcomes.

AB - Background and objectives Mineral and bone disorders (MBDs) are common in long-term dialysis patients and are risk factors for unfavorable outcomes. The associations between pretransplant levels of MBD surrogates and outcomes after kidney transplantation are not clear. Design, setting, participants, & measurements Data from the Scientific Registry of Transplant Recipients up to June 2007 were linked to the 5-year (July 2001-June 2006) cohort of a large dialysis organization in the United States. All dialysis patients who received a kidney transplant during this period were identified and divided into groups according to increments of pretransplant MBD markers. Unadjusted and multivariate adjusted predictors of transplant outcomes were examined. Results The 11,776 patients were aged 47±14 years and 39% were women. Compared with recipients with pretransplant time-averaged serum alkaline phosphatase of 80-120 U/L, recipients with pretransplant serum alkaline phosphatase of 120-160 and ≥160 U/L had 49% and 64% higher graft failure censored all-cause mortality in multivariable adjusted models. There was no significant association between time-averaged serum alkaline phosphatase categories and risk of death censored graft failure, delayed graft function (DGF), or acute rejection (AR). Compared with recipients with pretransplant time-averaged serum parathyroid hormone (PTH) levels of 150-300 pg/ml, there was no significant association with graft censored death among recipients with pretransplant serum PTH ≥800 pg/ml. In addition, the risk of graft failure, DGF, and AR did not show any association with time-averaged serum intact PTH level. There was no significant association between time-averaged serum calcium categories and risk of graft failure censored death, DGF, and AR. Conclusions In this cohort, hemodialysis patients with pretransplant serum alkaline phosphatase >120 U/L have unfavorable post-transplant mortality, whereas there was no association between serum PTH and serum calcium levels and post-transplant outcomes.

UR - http://www.scopus.com/inward/record.url?scp=84869122620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869122620&partnerID=8YFLogxK

U2 - 10.2215/CJN.01910212

DO - 10.2215/CJN.01910212

M3 - Article

VL - 7

SP - 1859

EP - 1871

JO - Clinical journal of the American Society of Nephrology : CJASN

JF - Clinical journal of the American Society of Nephrology : CJASN

SN - 1555-9041

IS - 11

ER -