Association of pro-inflammatory high-density lipoprotein cholesterol with clinical and laboratory variables in sickle cell disease

Kenneth Ataga, Alan Hinderliter, Julia E. Brittain, Susan Jones, Hao Xu, Jianwen Cai, Soyoung Kim, Kirkwood A. Pritchard, Cheryl A. Hillery

Research output: Contribution to journalArticle

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Abstract

Background: Although cholesterol levels are known to be decreased in sickle cell disease (SCD), the level of pro-inflammatory high-density lipoprotein cholesterol (proHDL) and its association with clinical complications and laboratory variables has not been evaluated. Design and methods: Plasma levels of total cholesterol, high-density lipoprotein cholesterol (HDL), proHDL, and selected clinical and laboratory variables were ascertained in a cohort of SCD patients and healthy African American control subjects in this single-center, cross-sectional study. Results: Although total cholesterol was significantly lower in SCD patients compared with control subjects, HDL and proHDL levels were similar in both the SCD and control groups. In univariate analyses, proHDL was correlated with echocardiography-derived tricuspid regurgitant jet velocity. ProHDL was higher in SCD patients with suspected pulmonary hypertension (PHT) compared to patients without suspected PHT. ProHDL was positively correlated with lactate dehydrogenase, total bilirubin, direct bilirubin, indirect bilirubin, prothrombin fragment 1+2, D-dimer, and thrombin–antithrombin complexes. In multivariable analyses, only higher lactate dehydrogenase and direct bilirubin levels were associated with higher levels of proHDL. Conclusions: SCD is characterized by hypocholesterolemia. Although proHDL is not increased in SCD patients compared with healthy controls, it is significantly associated with markers of liver disease. In addition, proHDL is associated with tricuspid regurgitant jet velocity and markers of coagulation, although these associations are not significant in multivariable analyses.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalHematology
Volume20
Issue number5
DOIs
StatePublished - Jan 1 2015

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Sickle Cell Anemia
HDL Cholesterol
Bilirubin
Cholesterol
L-Lactate Dehydrogenase
Pulmonary Hypertension
African Americans
Echocardiography
Liver Diseases
Cross-Sectional Studies
Control Groups

All Science Journal Classification (ASJC) codes

  • Hematology

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Association of pro-inflammatory high-density lipoprotein cholesterol with clinical and laboratory variables in sickle cell disease. / Ataga, Kenneth; Hinderliter, Alan; Brittain, Julia E.; Jones, Susan; Xu, Hao; Cai, Jianwen; Kim, Soyoung; Pritchard, Kirkwood A.; Hillery, Cheryl A.

In: Hematology, Vol. 20, No. 5, 01.01.2015, p. 289-296.

Research output: Contribution to journalArticle

Ataga, K, Hinderliter, A, Brittain, JE, Jones, S, Xu, H, Cai, J, Kim, S, Pritchard, KA & Hillery, CA 2015, 'Association of pro-inflammatory high-density lipoprotein cholesterol with clinical and laboratory variables in sickle cell disease', Hematology, vol. 20, no. 5, pp. 289-296. https://doi.org/10.1179/1607845414Y.0000000171
Ataga, Kenneth ; Hinderliter, Alan ; Brittain, Julia E. ; Jones, Susan ; Xu, Hao ; Cai, Jianwen ; Kim, Soyoung ; Pritchard, Kirkwood A. ; Hillery, Cheryl A. / Association of pro-inflammatory high-density lipoprotein cholesterol with clinical and laboratory variables in sickle cell disease. In: Hematology. 2015 ; Vol. 20, No. 5. pp. 289-296.
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