Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients: A meta-analysis

Konark Malhotra, Apostolos Safouris, Nitin Goyal, Adam Arthur, David S. Liebeskind, Aristeidis H. Katsanos, João Sargento-Freitas, Marc Ribo, Carlos Molina, Jong Won Chung, Oh Young Bang, Georgios Magoufis, Ahmad Cheema, Steven J. Shook, Ken Uchino, Andrei V. Alexandrov, Georgios Tsivgoulis

Research output: Contribution to journalArticle

Abstract

Background and aims: Statin pretreatment (SP) is associated with improved outcomes in acute ischemic stroke (AIS) patients. Collateral circulation status and final infarct volume (FIV) are independent predictors of functional outcome in AIS. Methods: We sought to evaluate the association of SP with collateral circulation and FIV in AIS patients. We used a random-effects model for all the analyses, and pooled standardized mean differences (SMDs) and odds ratios (OR) on the FIV and collateral status according to SP history, respectively. Results: We identified 9 eligible studies (1186 AIS patients). History of SP was associated with lower FIV (SMD = 0.25, 95%CI: 0.07–0.42, p = 0.005) compared to negative history of SP. A trend towards good collateral scores was observed in the SP group (OR = 1.45; 95% CI, 0.92–2.29, p = 0.11). Subgroup analysis demonstrated reduced FIV among atherosclerotic stroke patients with history of SP (SMD = 0.49; 95% CI, 0.19–0.80, p = 0.001). Conclusions: SP appears to be associated with decreased FIV, especially in atherosclerotic AIS.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalAtherosclerosis
Volume282
DOIs
StatePublished - Mar 2019

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Collateral Circulation
Meta-Analysis
Stroke
Odds Ratio
History

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients : A meta-analysis. / Malhotra, Konark; Safouris, Apostolos; Goyal, Nitin; Arthur, Adam; Liebeskind, David S.; Katsanos, Aristeidis H.; Sargento-Freitas, João; Ribo, Marc; Molina, Carlos; Chung, Jong Won; Bang, Oh Young; Magoufis, Georgios; Cheema, Ahmad; Shook, Steven J.; Uchino, Ken; Alexandrov, Andrei V.; Tsivgoulis, Georgios.

In: Atherosclerosis, Vol. 282, 03.2019, p. 75-79.

Research output: Contribution to journalArticle

Malhotra, K, Safouris, A, Goyal, N, Arthur, A, Liebeskind, DS, Katsanos, AH, Sargento-Freitas, J, Ribo, M, Molina, C, Chung, JW, Bang, OY, Magoufis, G, Cheema, A, Shook, SJ, Uchino, K, Alexandrov, AV & Tsivgoulis, G 2019, 'Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients: A meta-analysis', Atherosclerosis, vol. 282, pp. 75-79. https://doi.org/10.1016/j.atherosclerosis.2019.01.006
Malhotra, Konark ; Safouris, Apostolos ; Goyal, Nitin ; Arthur, Adam ; Liebeskind, David S. ; Katsanos, Aristeidis H. ; Sargento-Freitas, João ; Ribo, Marc ; Molina, Carlos ; Chung, Jong Won ; Bang, Oh Young ; Magoufis, Georgios ; Cheema, Ahmad ; Shook, Steven J. ; Uchino, Ken ; Alexandrov, Andrei V. ; Tsivgoulis, Georgios. / Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients : A meta-analysis. In: Atherosclerosis. 2019 ; Vol. 282. pp. 75-79.
@article{8f028dccabbe4668bb376d251fc663de,
title = "Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients: A meta-analysis",
abstract = "Background and aims: Statin pretreatment (SP) is associated with improved outcomes in acute ischemic stroke (AIS) patients. Collateral circulation status and final infarct volume (FIV) are independent predictors of functional outcome in AIS. Methods: We sought to evaluate the association of SP with collateral circulation and FIV in AIS patients. We used a random-effects model for all the analyses, and pooled standardized mean differences (SMDs) and odds ratios (OR) on the FIV and collateral status according to SP history, respectively. Results: We identified 9 eligible studies (1186 AIS patients). History of SP was associated with lower FIV (SMD = 0.25, 95{\%}CI: 0.07–0.42, p = 0.005) compared to negative history of SP. A trend towards good collateral scores was observed in the SP group (OR = 1.45; 95{\%} CI, 0.92–2.29, p = 0.11). Subgroup analysis demonstrated reduced FIV among atherosclerotic stroke patients with history of SP (SMD = 0.49; 95{\%} CI, 0.19–0.80, p = 0.001). Conclusions: SP appears to be associated with decreased FIV, especially in atherosclerotic AIS.",
author = "Konark Malhotra and Apostolos Safouris and Nitin Goyal and Adam Arthur and Liebeskind, {David S.} and Katsanos, {Aristeidis H.} and Jo{\~a}o Sargento-Freitas and Marc Ribo and Carlos Molina and Chung, {Jong Won} and Bang, {Oh Young} and Georgios Magoufis and Ahmad Cheema and Shook, {Steven J.} and Ken Uchino and Alexandrov, {Andrei V.} and Georgios Tsivgoulis",
year = "2019",
month = "3",
doi = "10.1016/j.atherosclerosis.2019.01.006",
language = "English (US)",
volume = "282",
pages = "75--79",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients

T2 - A meta-analysis

AU - Malhotra, Konark

AU - Safouris, Apostolos

AU - Goyal, Nitin

AU - Arthur, Adam

AU - Liebeskind, David S.

AU - Katsanos, Aristeidis H.

AU - Sargento-Freitas, João

AU - Ribo, Marc

AU - Molina, Carlos

AU - Chung, Jong Won

AU - Bang, Oh Young

AU - Magoufis, Georgios

AU - Cheema, Ahmad

AU - Shook, Steven J.

AU - Uchino, Ken

AU - Alexandrov, Andrei V.

AU - Tsivgoulis, Georgios

PY - 2019/3

Y1 - 2019/3

N2 - Background and aims: Statin pretreatment (SP) is associated with improved outcomes in acute ischemic stroke (AIS) patients. Collateral circulation status and final infarct volume (FIV) are independent predictors of functional outcome in AIS. Methods: We sought to evaluate the association of SP with collateral circulation and FIV in AIS patients. We used a random-effects model for all the analyses, and pooled standardized mean differences (SMDs) and odds ratios (OR) on the FIV and collateral status according to SP history, respectively. Results: We identified 9 eligible studies (1186 AIS patients). History of SP was associated with lower FIV (SMD = 0.25, 95%CI: 0.07–0.42, p = 0.005) compared to negative history of SP. A trend towards good collateral scores was observed in the SP group (OR = 1.45; 95% CI, 0.92–2.29, p = 0.11). Subgroup analysis demonstrated reduced FIV among atherosclerotic stroke patients with history of SP (SMD = 0.49; 95% CI, 0.19–0.80, p = 0.001). Conclusions: SP appears to be associated with decreased FIV, especially in atherosclerotic AIS.

AB - Background and aims: Statin pretreatment (SP) is associated with improved outcomes in acute ischemic stroke (AIS) patients. Collateral circulation status and final infarct volume (FIV) are independent predictors of functional outcome in AIS. Methods: We sought to evaluate the association of SP with collateral circulation and FIV in AIS patients. We used a random-effects model for all the analyses, and pooled standardized mean differences (SMDs) and odds ratios (OR) on the FIV and collateral status according to SP history, respectively. Results: We identified 9 eligible studies (1186 AIS patients). History of SP was associated with lower FIV (SMD = 0.25, 95%CI: 0.07–0.42, p = 0.005) compared to negative history of SP. A trend towards good collateral scores was observed in the SP group (OR = 1.45; 95% CI, 0.92–2.29, p = 0.11). Subgroup analysis demonstrated reduced FIV among atherosclerotic stroke patients with history of SP (SMD = 0.49; 95% CI, 0.19–0.80, p = 0.001). Conclusions: SP appears to be associated with decreased FIV, especially in atherosclerotic AIS.

UR - http://www.scopus.com/inward/record.url?scp=85060601542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060601542&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2019.01.006

DO - 10.1016/j.atherosclerosis.2019.01.006

M3 - Article

C2 - 30708178

AN - SCOPUS:85060601542

VL - 282

SP - 75

EP - 79

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -