Association of the malnutrition-inflammation score with clinical outcomes in kidney transplant recipients

Miklos Z. Molnar, Maria E. Czira, Anna Rudas, Akos Ujszaszi, Anett Lindner, Katalin Fornadi, Istvan Kiss, Adam Remport, Marta Novak, Sidney H. Kennedy, Laszlo Rosivall, Csaba Kovesdy, Istvan Mucsi

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The combination of chronic malnutrition and inflammation, often termed malnutritioninflammation complex syndrome or protein-energy wasting, is common in patients with chronic kidney disease. It is associated with increased mortality in patients on maintenance dialysis therapy. We assessed the association of malnutrition-inflammation score (MIS) with all-cause mortality and death-censored transplant loss or death with a functioning transplant in a sample of kidney transplant recipients. Study Design: Prospective prevalent cohort study. Setting & Participants: Data from 993 prevalent transplant recipients were analyzed. Sociodemographic parameters, laboratory data, medical and transplant history, comorbid conditions, estimated glomerular filtration rate, and MIS were tabulated at baseline and annually thereafter. Predictor: MIS, a 30-point scale expressed per 1 standard deviation (1 SD) unit or categorized as 3 (reference), 3-5, 6-8, and 8. The MIS is derived from 10 components, each with 4 levels of severity from 0 (normal) to 3 (severely abnormal). Higher score reflects more severe degree of malnutrition and inflammation status. Outcomes: All-cause mortality and death-censored transplant loss or death with a functioning transplant. Association of MIS with total mortality was assessed using time-dependent Cox regression analysis, and the association of MIS with death-censored transplant loss or death with a functioning transplant was assessed using semiparametric competing-risks regression analysis. Results: Mean age was 51 13 years, 57% of patients were men, and 21% had diabetes. Percentages of patients in the MIS categories 3, 3-5, 6-8, and 8 were 40%, 32%, 20%, and 8%, respectively. In multivariable time-dependent Cox regression analyses, time-varying MIS score was a significant predictor of all-cause mortality (HR per 1-SD increase, 1.59; 95% CI, 1.37-1.85), death with a functioning transplant (HR per 1-SD increase, 1.48; 95% CI, 1.23-1.78), and death-censored transplant loss (HR per 1-SD increase, 1.34; 95% CI, 1.04-1.71). Compared with MIS 3, HRs for all-cause mortality for MIS of 3-5, 6-8, and 8 were 1.53 (95% CI, 0.74-3.15), 3.66 (95% CI, 1.87-7.14), and 6.82 (95% CI, 3.34-13.91), respectively. Limitations: Single-center study, small number of outcomes. Conclusions: The MIS, a simple tool to assess the presence of malnutrition-inflammation complex syndrome, predicts mortality in kidney transplant recipients.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume58
Issue number1
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

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Malnutrition
Inflammation
Kidney
Transplants
Mortality
Regression Analysis
Transplant Recipients
Cause of Death
Glomerular Filtration Rate
Chronic Renal Insufficiency
Dialysis
Cohort Studies
History
Maintenance
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Molnar, M. Z., Czira, M. E., Rudas, A., Ujszaszi, A., Lindner, A., Fornadi, K., ... Mucsi, I. (2011). Association of the malnutrition-inflammation score with clinical outcomes in kidney transplant recipients. American Journal of Kidney Diseases, 58(1), 101-108. https://doi.org/10.1053/j.ajkd.2010.11.027

Association of the malnutrition-inflammation score with clinical outcomes in kidney transplant recipients. / Molnar, Miklos Z.; Czira, Maria E.; Rudas, Anna; Ujszaszi, Akos; Lindner, Anett; Fornadi, Katalin; Kiss, Istvan; Remport, Adam; Novak, Marta; Kennedy, Sidney H.; Rosivall, Laszlo; Kovesdy, Csaba; Mucsi, Istvan.

In: American Journal of Kidney Diseases, Vol. 58, No. 1, 01.07.2011, p. 101-108.

Research output: Contribution to journalArticle

Molnar, MZ, Czira, ME, Rudas, A, Ujszaszi, A, Lindner, A, Fornadi, K, Kiss, I, Remport, A, Novak, M, Kennedy, SH, Rosivall, L, Kovesdy, C & Mucsi, I 2011, 'Association of the malnutrition-inflammation score with clinical outcomes in kidney transplant recipients', American Journal of Kidney Diseases, vol. 58, no. 1, pp. 101-108. https://doi.org/10.1053/j.ajkd.2010.11.027
Molnar, Miklos Z. ; Czira, Maria E. ; Rudas, Anna ; Ujszaszi, Akos ; Lindner, Anett ; Fornadi, Katalin ; Kiss, Istvan ; Remport, Adam ; Novak, Marta ; Kennedy, Sidney H. ; Rosivall, Laszlo ; Kovesdy, Csaba ; Mucsi, Istvan. / Association of the malnutrition-inflammation score with clinical outcomes in kidney transplant recipients. In: American Journal of Kidney Diseases. 2011 ; Vol. 58, No. 1. pp. 101-108.
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abstract = "The combination of chronic malnutrition and inflammation, often termed malnutritioninflammation complex syndrome or protein-energy wasting, is common in patients with chronic kidney disease. It is associated with increased mortality in patients on maintenance dialysis therapy. We assessed the association of malnutrition-inflammation score (MIS) with all-cause mortality and death-censored transplant loss or death with a functioning transplant in a sample of kidney transplant recipients. Study Design: Prospective prevalent cohort study. Setting & Participants: Data from 993 prevalent transplant recipients were analyzed. Sociodemographic parameters, laboratory data, medical and transplant history, comorbid conditions, estimated glomerular filtration rate, and MIS were tabulated at baseline and annually thereafter. Predictor: MIS, a 30-point scale expressed per 1 standard deviation (1 SD) unit or categorized as 3 (reference), 3-5, 6-8, and 8. The MIS is derived from 10 components, each with 4 levels of severity from 0 (normal) to 3 (severely abnormal). Higher score reflects more severe degree of malnutrition and inflammation status. Outcomes: All-cause mortality and death-censored transplant loss or death with a functioning transplant. Association of MIS with total mortality was assessed using time-dependent Cox regression analysis, and the association of MIS with death-censored transplant loss or death with a functioning transplant was assessed using semiparametric competing-risks regression analysis. Results: Mean age was 51 13 years, 57{\%} of patients were men, and 21{\%} had diabetes. Percentages of patients in the MIS categories 3, 3-5, 6-8, and 8 were 40{\%}, 32{\%}, 20{\%}, and 8{\%}, respectively. In multivariable time-dependent Cox regression analyses, time-varying MIS score was a significant predictor of all-cause mortality (HR per 1-SD increase, 1.59; 95{\%} CI, 1.37-1.85), death with a functioning transplant (HR per 1-SD increase, 1.48; 95{\%} CI, 1.23-1.78), and death-censored transplant loss (HR per 1-SD increase, 1.34; 95{\%} CI, 1.04-1.71). Compared with MIS 3, HRs for all-cause mortality for MIS of 3-5, 6-8, and 8 were 1.53 (95{\%} CI, 0.74-3.15), 3.66 (95{\%} CI, 1.87-7.14), and 6.82 (95{\%} CI, 3.34-13.91), respectively. Limitations: Single-center study, small number of outcomes. Conclusions: The MIS, a simple tool to assess the presence of malnutrition-inflammation complex syndrome, predicts mortality in kidney transplant recipients.",
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AU - Molnar, Miklos Z.

AU - Czira, Maria E.

AU - Rudas, Anna

AU - Ujszaszi, Akos

AU - Lindner, Anett

AU - Fornadi, Katalin

AU - Kiss, Istvan

AU - Remport, Adam

AU - Novak, Marta

AU - Kennedy, Sidney H.

AU - Rosivall, Laszlo

AU - Kovesdy, Csaba

AU - Mucsi, Istvan

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N2 - The combination of chronic malnutrition and inflammation, often termed malnutritioninflammation complex syndrome or protein-energy wasting, is common in patients with chronic kidney disease. It is associated with increased mortality in patients on maintenance dialysis therapy. We assessed the association of malnutrition-inflammation score (MIS) with all-cause mortality and death-censored transplant loss or death with a functioning transplant in a sample of kidney transplant recipients. Study Design: Prospective prevalent cohort study. Setting & Participants: Data from 993 prevalent transplant recipients were analyzed. Sociodemographic parameters, laboratory data, medical and transplant history, comorbid conditions, estimated glomerular filtration rate, and MIS were tabulated at baseline and annually thereafter. Predictor: MIS, a 30-point scale expressed per 1 standard deviation (1 SD) unit or categorized as 3 (reference), 3-5, 6-8, and 8. The MIS is derived from 10 components, each with 4 levels of severity from 0 (normal) to 3 (severely abnormal). Higher score reflects more severe degree of malnutrition and inflammation status. Outcomes: All-cause mortality and death-censored transplant loss or death with a functioning transplant. Association of MIS with total mortality was assessed using time-dependent Cox regression analysis, and the association of MIS with death-censored transplant loss or death with a functioning transplant was assessed using semiparametric competing-risks regression analysis. Results: Mean age was 51 13 years, 57% of patients were men, and 21% had diabetes. Percentages of patients in the MIS categories 3, 3-5, 6-8, and 8 were 40%, 32%, 20%, and 8%, respectively. In multivariable time-dependent Cox regression analyses, time-varying MIS score was a significant predictor of all-cause mortality (HR per 1-SD increase, 1.59; 95% CI, 1.37-1.85), death with a functioning transplant (HR per 1-SD increase, 1.48; 95% CI, 1.23-1.78), and death-censored transplant loss (HR per 1-SD increase, 1.34; 95% CI, 1.04-1.71). Compared with MIS 3, HRs for all-cause mortality for MIS of 3-5, 6-8, and 8 were 1.53 (95% CI, 0.74-3.15), 3.66 (95% CI, 1.87-7.14), and 6.82 (95% CI, 3.34-13.91), respectively. Limitations: Single-center study, small number of outcomes. Conclusions: The MIS, a simple tool to assess the presence of malnutrition-inflammation complex syndrome, predicts mortality in kidney transplant recipients.

AB - The combination of chronic malnutrition and inflammation, often termed malnutritioninflammation complex syndrome or protein-energy wasting, is common in patients with chronic kidney disease. It is associated with increased mortality in patients on maintenance dialysis therapy. We assessed the association of malnutrition-inflammation score (MIS) with all-cause mortality and death-censored transplant loss or death with a functioning transplant in a sample of kidney transplant recipients. Study Design: Prospective prevalent cohort study. Setting & Participants: Data from 993 prevalent transplant recipients were analyzed. Sociodemographic parameters, laboratory data, medical and transplant history, comorbid conditions, estimated glomerular filtration rate, and MIS were tabulated at baseline and annually thereafter. Predictor: MIS, a 30-point scale expressed per 1 standard deviation (1 SD) unit or categorized as 3 (reference), 3-5, 6-8, and 8. The MIS is derived from 10 components, each with 4 levels of severity from 0 (normal) to 3 (severely abnormal). Higher score reflects more severe degree of malnutrition and inflammation status. Outcomes: All-cause mortality and death-censored transplant loss or death with a functioning transplant. Association of MIS with total mortality was assessed using time-dependent Cox regression analysis, and the association of MIS with death-censored transplant loss or death with a functioning transplant was assessed using semiparametric competing-risks regression analysis. Results: Mean age was 51 13 years, 57% of patients were men, and 21% had diabetes. Percentages of patients in the MIS categories 3, 3-5, 6-8, and 8 were 40%, 32%, 20%, and 8%, respectively. In multivariable time-dependent Cox regression analyses, time-varying MIS score was a significant predictor of all-cause mortality (HR per 1-SD increase, 1.59; 95% CI, 1.37-1.85), death with a functioning transplant (HR per 1-SD increase, 1.48; 95% CI, 1.23-1.78), and death-censored transplant loss (HR per 1-SD increase, 1.34; 95% CI, 1.04-1.71). Compared with MIS 3, HRs for all-cause mortality for MIS of 3-5, 6-8, and 8 were 1.53 (95% CI, 0.74-3.15), 3.66 (95% CI, 1.87-7.14), and 6.82 (95% CI, 3.34-13.91), respectively. Limitations: Single-center study, small number of outcomes. Conclusions: The MIS, a simple tool to assess the presence of malnutrition-inflammation complex syndrome, predicts mortality in kidney transplant recipients.

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