Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Xiao Qin Wang, Paul Terry, Yang Li, Yue Zhang, Wen Jing Kou, Ming Xu Wang

Research output: Contribution to journalArticle

Abstract

BACKGROUND The xeroderma pigmentosum group G (XPG) gene at chromosome 13q33 consists of 15 exons, which may be related to the occurrence and development of gastric cancer (GC). AIM To examine the association of several common single nucleotide polymorphisms (SNPs) of the XPG gene with GC risk and survival. METHODS Five SNPs of XPG (rs2094258, rs751402, rs873601, rs2296147, and rs1047768) were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North China. GC patients were followed for survival status and, if deceased, cause of death. Logistic regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis, respectively. For rs2094258, heterozygous model (CT vs CC), homozygous model (TT vs CC), recessive model (TT vs CT + CC), and dominant model (TT + CT vs CC) were analyzed. RESULTS None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (P = 0.050). GC patients with the rs2094258 CT + CC genotype showed worse survival than those with the TT genotype (log-rank test, P = 0.028), and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT + CT genotype (log-rank test, P = 0.039). The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, P = 0.037] were associated with the long-term survival of GC cases. Other risk factors for survival included tumor differentiation (HR = 4.51, 95%CI: 1.99-8.23, P < 0.001), lymphovascular invasion (HR = 1.97, 95%CI: 1.44-3.01, P < 0.001), and use of chemotherapy (HR = 0.81, 95%CI: 0.63-0.98, P = 0.041). CONCLUSION The XPG rs2094258 polymorphism may be associated with overall survival in GC patients.

Original languageEnglish (US)
Pages (from-to)5152-5161
Number of pages10
JournalWorld Journal of Gastroenterology
Volume25
Issue number34
DOIs
StatePublished - Sep 14 2019

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Xeroderma Pigmentosum
Stomach Neoplasms
Survival
Genotype
Confidence Intervals
Single Nucleotide Polymorphism
Restriction Fragment Length Polymorphisms
Genes
Cause of Death
Exons
China
Chromosomes
Logistic Models
Alleles
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Association of XPG rs2094258 polymorphism with gastric cancer prognosis. / Wang, Xiao Qin; Terry, Paul; Li, Yang; Zhang, Yue; Kou, Wen Jing; Wang, Ming Xu.

In: World Journal of Gastroenterology, Vol. 25, No. 34, 14.09.2019, p. 5152-5161.

Research output: Contribution to journalArticle

Wang, Xiao Qin ; Terry, Paul ; Li, Yang ; Zhang, Yue ; Kou, Wen Jing ; Wang, Ming Xu. / Association of XPG rs2094258 polymorphism with gastric cancer prognosis. In: World Journal of Gastroenterology. 2019 ; Vol. 25, No. 34. pp. 5152-5161.
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abstract = "BACKGROUND The xeroderma pigmentosum group G (XPG) gene at chromosome 13q33 consists of 15 exons, which may be related to the occurrence and development of gastric cancer (GC). AIM To examine the association of several common single nucleotide polymorphisms (SNPs) of the XPG gene with GC risk and survival. METHODS Five SNPs of XPG (rs2094258, rs751402, rs873601, rs2296147, and rs1047768) were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North China. GC patients were followed for survival status and, if deceased, cause of death. Logistic regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis, respectively. For rs2094258, heterozygous model (CT vs CC), homozygous model (TT vs CC), recessive model (TT vs CT + CC), and dominant model (TT + CT vs CC) were analyzed. RESULTS None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (P = 0.050). GC patients with the rs2094258 CT + CC genotype showed worse survival than those with the TT genotype (log-rank test, P = 0.028), and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT + CT genotype (log-rank test, P = 0.039). The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95{\%} confidence interval (CI): 1.02-1.45, P = 0.037] were associated with the long-term survival of GC cases. Other risk factors for survival included tumor differentiation (HR = 4.51, 95{\%}CI: 1.99-8.23, P < 0.001), lymphovascular invasion (HR = 1.97, 95{\%}CI: 1.44-3.01, P < 0.001), and use of chemotherapy (HR = 0.81, 95{\%}CI: 0.63-0.98, P = 0.041). CONCLUSION The XPG rs2094258 polymorphism may be associated with overall survival in GC patients.",
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T1 - Association of XPG rs2094258 polymorphism with gastric cancer prognosis

AU - Wang, Xiao Qin

AU - Terry, Paul

AU - Li, Yang

AU - Zhang, Yue

AU - Kou, Wen Jing

AU - Wang, Ming Xu

PY - 2019/9/14

Y1 - 2019/9/14

N2 - BACKGROUND The xeroderma pigmentosum group G (XPG) gene at chromosome 13q33 consists of 15 exons, which may be related to the occurrence and development of gastric cancer (GC). AIM To examine the association of several common single nucleotide polymorphisms (SNPs) of the XPG gene with GC risk and survival. METHODS Five SNPs of XPG (rs2094258, rs751402, rs873601, rs2296147, and rs1047768) were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North China. GC patients were followed for survival status and, if deceased, cause of death. Logistic regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis, respectively. For rs2094258, heterozygous model (CT vs CC), homozygous model (TT vs CC), recessive model (TT vs CT + CC), and dominant model (TT + CT vs CC) were analyzed. RESULTS None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (P = 0.050). GC patients with the rs2094258 CT + CC genotype showed worse survival than those with the TT genotype (log-rank test, P = 0.028), and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT + CT genotype (log-rank test, P = 0.039). The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, P = 0.037] were associated with the long-term survival of GC cases. Other risk factors for survival included tumor differentiation (HR = 4.51, 95%CI: 1.99-8.23, P < 0.001), lymphovascular invasion (HR = 1.97, 95%CI: 1.44-3.01, P < 0.001), and use of chemotherapy (HR = 0.81, 95%CI: 0.63-0.98, P = 0.041). CONCLUSION The XPG rs2094258 polymorphism may be associated with overall survival in GC patients.

AB - BACKGROUND The xeroderma pigmentosum group G (XPG) gene at chromosome 13q33 consists of 15 exons, which may be related to the occurrence and development of gastric cancer (GC). AIM To examine the association of several common single nucleotide polymorphisms (SNPs) of the XPG gene with GC risk and survival. METHODS Five SNPs of XPG (rs2094258, rs751402, rs873601, rs2296147, and rs1047768) were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North China. GC patients were followed for survival status and, if deceased, cause of death. Logistic regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis, respectively. For rs2094258, heterozygous model (CT vs CC), homozygous model (TT vs CC), recessive model (TT vs CT + CC), and dominant model (TT + CT vs CC) were analyzed. RESULTS None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (P = 0.050). GC patients with the rs2094258 CT + CC genotype showed worse survival than those with the TT genotype (log-rank test, P = 0.028), and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT + CT genotype (log-rank test, P = 0.039). The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, P = 0.037] were associated with the long-term survival of GC cases. Other risk factors for survival included tumor differentiation (HR = 4.51, 95%CI: 1.99-8.23, P < 0.001), lymphovascular invasion (HR = 1.97, 95%CI: 1.44-3.01, P < 0.001), and use of chemotherapy (HR = 0.81, 95%CI: 0.63-0.98, P = 0.041). CONCLUSION The XPG rs2094258 polymorphism may be associated with overall survival in GC patients.

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