Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese

Yaping Wang, Biao Li, Weiyan Zhao, Pei Liu, Qi Zhao, Shufeng Chen, Hongfan Li, Dongfeng Gu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

To investigate the association between polymorphisms in the G protein-coupled receptor kinase 4 gene (GRK4) (R65L, A142V and A486V) and essential hypertension in northern Han Chinese, we conducted a case-control study consisting of 503 individuals with essential hypertension (HT) and 490 age-, gender-, and area-matched normotensive (NT) controls. The three GRK4 variants were genotyped by PCR-RFLP analysis. Both haplotype and single locus analysis were used to process the genotyping data. The A486 allele showed a significant association with HT (P < 0.001). A total of 6 haplotypes were observed in the entire population, with the haplotypes L-V-A and R-A-A being found to be significantly related to hypertension (P = 0.001).

Original languageEnglish (US)
Pages (from-to)778-783
Number of pages6
JournalAnnals of Human Genetics
Volume70
Issue number6
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

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G-Protein-Coupled Receptor Kinase 4
Haplotypes
Genes
Hypertension
Restriction Fragment Length Polymorphisms
Case-Control Studies
Alleles
Polymerase Chain Reaction
Population
Essential Hypertension

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese. / Wang, Yaping; Li, Biao; Zhao, Weiyan; Liu, Pei; Zhao, Qi; Chen, Shufeng; Li, Hongfan; Gu, Dongfeng.

In: Annals of Human Genetics, Vol. 70, No. 6, 01.11.2006, p. 778-783.

Research output: Contribution to journalArticle

Wang, Yaping ; Li, Biao ; Zhao, Weiyan ; Liu, Pei ; Zhao, Qi ; Chen, Shufeng ; Li, Hongfan ; Gu, Dongfeng. / Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese. In: Annals of Human Genetics. 2006 ; Vol. 70, No. 6. pp. 778-783.
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