Associations of body mass index, smoking, and alcohol consumption with prostate cancer mortality in the Asia cohort consortium

Jay H. Fowke, Dale F. McLerran, Prakash C. Gupta, Jiang He, Xiao Ou Shu, Kunnambath Ramadas, Shoichiro Tsugane, Manami Inoue, Akiko Tamakoshi, Woon Puay Koh, Yoshikazu Nishino, Ichiro Tsuji, Kotaro Ozasa, Jian Min Yuan, Hideo Tanaka, Yoon Ok Ahn, Chien Jen Chen, Yumi Sugawara, Keun Young Yoo, Habibul AhsanWen Harn Pan, Mangesh Pednekar, Dongfeng Gu, Yong Bing Xiang, Catherine Sauvaget, Norie Sawada, Renwei Wang, Masako Kakizaki, Yasutake Tomata, Waka Ohishi, Lesley M. Butler, Isao Oze, Dong Hyun Kim, San Lin You, Sue K. Park, Faruque Parvez, Shao Yuan Chuang, Yu Chen, Jung Eun Lee, Eric Grant, Betsy Rolland, Mark Thornquist, Ziding Feng, Wei Zheng, Paolo Boffetta, Rashmi Sinha, Daehee Kang, John D. Potter

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Abstract

Many potentially modifiable risk factors for prostate cancer are also associated with prostate cancer screening, which may induce a bias in epidemiologic studies. We investigated the associations of body mass index (weight (kg)/height (m)2), smoking, and alcohol consumption with risk of fatal prostate cancer in Asian countries where prostate cancer screening is not widely utilized. Analysis included 18 prospective cohort studies conducted during 1963-2006 across 6 countries in southern and eastern Asia that are part of the Asia Cohort Consortium. Body mass index, smoking, and alcohol intake were determined by questionnaire at baseline, and cause of death was ascertained through death certificates. Analysis included 522,736 men aged 54 years, on average, at baseline. During 4.8 million person-years of follow-up, there were 634 prostate cancer deaths (367 prostate cancer deaths across the 11 cohorts with alcohol data). In Cox proportional hazards analyses of all cohorts in the Asia Cohort Consortium, prostate cancer mortality was not significantly associated with obesity (body mass index >25: hazard ratio (HR) = 1.08, 95% confidence interval (CI): 0.85, 1.36), ever smoking (HR = 1.00, 95% CI: 0.84, 1.21), or heavy alcohol intake (HR = 1.00, 95% CI: 0.74, 1.35). Differences in prostate cancer screening and detection probably contribute to differences in the association of obesity, smoking, or alcohol intake with prostate cancer risk and mortality between Asian and Western populations and thus require further investigation.

Original languageEnglish (US)
Pages (from-to)381-389
Number of pages9
JournalAmerican Journal of Epidemiology
Volume182
Issue number5
DOIs
StatePublished - Sep 1 2015

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Alcohol Drinking
Prostatic Neoplasms
Body Mass Index
Smoking
Mortality
Early Detection of Cancer
Alcohols
Confidence Intervals
Cohort Studies
Obesity
Death Certificates
Far East
Epidemiologic Studies
Cause of Death
Prospective Studies
Weights and Measures
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Associations of body mass index, smoking, and alcohol consumption with prostate cancer mortality in the Asia cohort consortium. / Fowke, Jay H.; McLerran, Dale F.; Gupta, Prakash C.; He, Jiang; Shu, Xiao Ou; Ramadas, Kunnambath; Tsugane, Shoichiro; Inoue, Manami; Tamakoshi, Akiko; Koh, Woon Puay; Nishino, Yoshikazu; Tsuji, Ichiro; Ozasa, Kotaro; Yuan, Jian Min; Tanaka, Hideo; Ahn, Yoon Ok; Chen, Chien Jen; Sugawara, Yumi; Yoo, Keun Young; Ahsan, Habibul; Pan, Wen Harn; Pednekar, Mangesh; Gu, Dongfeng; Xiang, Yong Bing; Sauvaget, Catherine; Sawada, Norie; Wang, Renwei; Kakizaki, Masako; Tomata, Yasutake; Ohishi, Waka; Butler, Lesley M.; Oze, Isao; Kim, Dong Hyun; You, San Lin; Park, Sue K.; Parvez, Faruque; Chuang, Shao Yuan; Chen, Yu; Lee, Jung Eun; Grant, Eric; Rolland, Betsy; Thornquist, Mark; Feng, Ziding; Zheng, Wei; Boffetta, Paolo; Sinha, Rashmi; Kang, Daehee; Potter, John D.

In: American Journal of Epidemiology, Vol. 182, No. 5, 01.09.2015, p. 381-389.

Research output: Contribution to journalArticle

Fowke, JH, McLerran, DF, Gupta, PC, He, J, Shu, XO, Ramadas, K, Tsugane, S, Inoue, M, Tamakoshi, A, Koh, WP, Nishino, Y, Tsuji, I, Ozasa, K, Yuan, JM, Tanaka, H, Ahn, YO, Chen, CJ, Sugawara, Y, Yoo, KY, Ahsan, H, Pan, WH, Pednekar, M, Gu, D, Xiang, YB, Sauvaget, C, Sawada, N, Wang, R, Kakizaki, M, Tomata, Y, Ohishi, W, Butler, LM, Oze, I, Kim, DH, You, SL, Park, SK, Parvez, F, Chuang, SY, Chen, Y, Lee, JE, Grant, E, Rolland, B, Thornquist, M, Feng, Z, Zheng, W, Boffetta, P, Sinha, R, Kang, D & Potter, JD 2015, 'Associations of body mass index, smoking, and alcohol consumption with prostate cancer mortality in the Asia cohort consortium', American Journal of Epidemiology, vol. 182, no. 5, pp. 381-389. https://doi.org/10.1093/aje/kwv089
Fowke, Jay H. ; McLerran, Dale F. ; Gupta, Prakash C. ; He, Jiang ; Shu, Xiao Ou ; Ramadas, Kunnambath ; Tsugane, Shoichiro ; Inoue, Manami ; Tamakoshi, Akiko ; Koh, Woon Puay ; Nishino, Yoshikazu ; Tsuji, Ichiro ; Ozasa, Kotaro ; Yuan, Jian Min ; Tanaka, Hideo ; Ahn, Yoon Ok ; Chen, Chien Jen ; Sugawara, Yumi ; Yoo, Keun Young ; Ahsan, Habibul ; Pan, Wen Harn ; Pednekar, Mangesh ; Gu, Dongfeng ; Xiang, Yong Bing ; Sauvaget, Catherine ; Sawada, Norie ; Wang, Renwei ; Kakizaki, Masako ; Tomata, Yasutake ; Ohishi, Waka ; Butler, Lesley M. ; Oze, Isao ; Kim, Dong Hyun ; You, San Lin ; Park, Sue K. ; Parvez, Faruque ; Chuang, Shao Yuan ; Chen, Yu ; Lee, Jung Eun ; Grant, Eric ; Rolland, Betsy ; Thornquist, Mark ; Feng, Ziding ; Zheng, Wei ; Boffetta, Paolo ; Sinha, Rashmi ; Kang, Daehee ; Potter, John D. / Associations of body mass index, smoking, and alcohol consumption with prostate cancer mortality in the Asia cohort consortium. In: American Journal of Epidemiology. 2015 ; Vol. 182, No. 5. pp. 381-389.
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abstract = "Many potentially modifiable risk factors for prostate cancer are also associated with prostate cancer screening, which may induce a bias in epidemiologic studies. We investigated the associations of body mass index (weight (kg)/height (m)2), smoking, and alcohol consumption with risk of fatal prostate cancer in Asian countries where prostate cancer screening is not widely utilized. Analysis included 18 prospective cohort studies conducted during 1963-2006 across 6 countries in southern and eastern Asia that are part of the Asia Cohort Consortium. Body mass index, smoking, and alcohol intake were determined by questionnaire at baseline, and cause of death was ascertained through death certificates. Analysis included 522,736 men aged 54 years, on average, at baseline. During 4.8 million person-years of follow-up, there were 634 prostate cancer deaths (367 prostate cancer deaths across the 11 cohorts with alcohol data). In Cox proportional hazards analyses of all cohorts in the Asia Cohort Consortium, prostate cancer mortality was not significantly associated with obesity (body mass index >25: hazard ratio (HR) = 1.08, 95{\%} confidence interval (CI): 0.85, 1.36), ever smoking (HR = 1.00, 95{\%} CI: 0.84, 1.21), or heavy alcohol intake (HR = 1.00, 95{\%} CI: 0.74, 1.35). Differences in prostate cancer screening and detection probably contribute to differences in the association of obesity, smoking, or alcohol intake with prostate cancer risk and mortality between Asian and Western populations and thus require further investigation.",
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AU - You, San Lin

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AU - Parvez, Faruque

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AU - Chen, Yu

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AU - Grant, Eric

AU - Rolland, Betsy

AU - Thornquist, Mark

AU - Feng, Ziding

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