Associations of the Expanded Disability Status Scale with anxiety and depression in multiple sclerosis outpatients

Georgios Tsivgoulis, N. Triantafyllou, C. Papageorgiou, M. E. Evangelopoulos, E. Kararizou, C. Sfagos, D. Vassilopoulos

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objectives - We evaluated cross-sectionally the associations of depression and anxiety with age, sex, duration of illness, educational level, degree of disability and treatment with interferon-β in outpatients with relapsing-remitting multiple sclerosis (RRMS) during a clinically stable phase of their illness. Materials and methods - The depression status scored on the Beck Depression Inventory (BDI), the symptoms of anxiety assessed using the State Trait Anxiety Inventory (STAI) and the level of disability measured by the Expanded Disability Status Scale (EDSS) were quantified in 86 consecutive RRMS patients. Results - Linear regression analyses indicated that EDSS was independently (P < 0.001) associated with BDI and STAI and accounted for 15.7% and 18.5% of the variance in BDI and STAI respectively. The former association retained its statistical significance in multiple regression models adjusting for demographic and clinical characteristics. Conclusions - Disability status is an independent but moderate determinant of depression and anxiety in MS patients.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalActa Neurologica Scandinavica
Volume115
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

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Multiple Sclerosis
Outpatients
Anxiety
Depression
Equipment and Supplies
Relapsing-Remitting Multiple Sclerosis
Interferons
Linear Models
Regression Analysis
Demography

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Associations of the Expanded Disability Status Scale with anxiety and depression in multiple sclerosis outpatients. / Tsivgoulis, Georgios; Triantafyllou, N.; Papageorgiou, C.; Evangelopoulos, M. E.; Kararizou, E.; Sfagos, C.; Vassilopoulos, D.

In: Acta Neurologica Scandinavica, Vol. 115, No. 1, 01.01.2007, p. 67-72.

Research output: Contribution to journalArticle

Tsivgoulis, G, Triantafyllou, N, Papageorgiou, C, Evangelopoulos, ME, Kararizou, E, Sfagos, C & Vassilopoulos, D 2007, 'Associations of the Expanded Disability Status Scale with anxiety and depression in multiple sclerosis outpatients', Acta Neurologica Scandinavica, vol. 115, no. 1, pp. 67-72. https://doi.org/10.1111/j.1600-0404.2006.00736.x
Tsivgoulis, Georgios ; Triantafyllou, N. ; Papageorgiou, C. ; Evangelopoulos, M. E. ; Kararizou, E. ; Sfagos, C. ; Vassilopoulos, D. / Associations of the Expanded Disability Status Scale with anxiety and depression in multiple sclerosis outpatients. In: Acta Neurologica Scandinavica. 2007 ; Vol. 115, No. 1. pp. 67-72.
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abstract = "Objectives - We evaluated cross-sectionally the associations of depression and anxiety with age, sex, duration of illness, educational level, degree of disability and treatment with interferon-β in outpatients with relapsing-remitting multiple sclerosis (RRMS) during a clinically stable phase of their illness. Materials and methods - The depression status scored on the Beck Depression Inventory (BDI), the symptoms of anxiety assessed using the State Trait Anxiety Inventory (STAI) and the level of disability measured by the Expanded Disability Status Scale (EDSS) were quantified in 86 consecutive RRMS patients. Results - Linear regression analyses indicated that EDSS was independently (P < 0.001) associated with BDI and STAI and accounted for 15.7{\%} and 18.5{\%} of the variance in BDI and STAI respectively. The former association retained its statistical significance in multiple regression models adjusting for demographic and clinical characteristics. Conclusions - Disability status is an independent but moderate determinant of depression and anxiety in MS patients.",
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