Asymmetries in the effect of side of seizure onset on recognition memory following intracarotid amobarbital injection

J. I. Breier, A. B. Thomas, P. M. Plenger, James Wheless, B. L. Brookshire, Andrew Papanicolaou, L. J. Willmore

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: To assess interhemispheric differences in recognition memory for objects during the intracarotid amobarbital sodium procedure (IAP). Methods: The recognition memory for real objects of patients with either right (RTLE; n = 28) or left (LTLE; n = 22) temporal lobe epilepsy was assessed at baseline, and after left and fight intracarotid amobarbital sodium injection. Results: There were no differences between groups on baseline performance. Performance following injection ipsilateral to the side of seizure focus was relatively lower for the LTLE as compared with the RTLE group, but this difference did not reach statistical significance. However, performance following injection contralateral to the side of seizure focus was significantly lower for the RTLE as compared with the LTLE group. Within- group differences in performance after ipsilateral as compared with contralateral injection were significant for the RTLE but not the LTLE group. The difference in interhemispheric asymmetry in IAP memory performance between RTLE and LTLE groups was reflected in decreased ability to classify LTLE patients as compared with RTLE patients about side of seizure onset, using a clinically applicable decision role. Conclusions: Recognition memory during the IAP for real objects, simultaneously named and presented visually during encoding, is mediated effectively by both the left and right hemisphere when there is no seizure focus present. However, memory appears to be more vulnerable to the presence of a seizure focus in the right as compared with the left hemisphere.

Original languageEnglish (US)
Pages (from-to)1209-1215
Number of pages7
JournalEpilepsia
Volume38
Issue number11
DOIs
StatePublished - Nov 1 1997

Fingerprint

Amobarbital
Seizures
Injections
Aptitude
Temporal Lobe Epilepsy
Recognition (Psychology)

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Breier, J. I., Thomas, A. B., Plenger, P. M., Wheless, J., Brookshire, B. L., Papanicolaou, A., & Willmore, L. J. (1997). Asymmetries in the effect of side of seizure onset on recognition memory following intracarotid amobarbital injection. Epilepsia, 38(11), 1209-1215. https://doi.org/10.1111/j.1528-1157.1997.tb01218.x

Asymmetries in the effect of side of seizure onset on recognition memory following intracarotid amobarbital injection. / Breier, J. I.; Thomas, A. B.; Plenger, P. M.; Wheless, James; Brookshire, B. L.; Papanicolaou, Andrew; Willmore, L. J.

In: Epilepsia, Vol. 38, No. 11, 01.11.1997, p. 1209-1215.

Research output: Contribution to journalArticle

Breier, JI, Thomas, AB, Plenger, PM, Wheless, J, Brookshire, BL, Papanicolaou, A & Willmore, LJ 1997, 'Asymmetries in the effect of side of seizure onset on recognition memory following intracarotid amobarbital injection', Epilepsia, vol. 38, no. 11, pp. 1209-1215. https://doi.org/10.1111/j.1528-1157.1997.tb01218.x
Breier, J. I. ; Thomas, A. B. ; Plenger, P. M. ; Wheless, James ; Brookshire, B. L. ; Papanicolaou, Andrew ; Willmore, L. J. / Asymmetries in the effect of side of seizure onset on recognition memory following intracarotid amobarbital injection. In: Epilepsia. 1997 ; Vol. 38, No. 11. pp. 1209-1215.
@article{2ce45f4714a245c994c8122e85becf3c,
title = "Asymmetries in the effect of side of seizure onset on recognition memory following intracarotid amobarbital injection",
abstract = "Purpose: To assess interhemispheric differences in recognition memory for objects during the intracarotid amobarbital sodium procedure (IAP). Methods: The recognition memory for real objects of patients with either right (RTLE; n = 28) or left (LTLE; n = 22) temporal lobe epilepsy was assessed at baseline, and after left and fight intracarotid amobarbital sodium injection. Results: There were no differences between groups on baseline performance. Performance following injection ipsilateral to the side of seizure focus was relatively lower for the LTLE as compared with the RTLE group, but this difference did not reach statistical significance. However, performance following injection contralateral to the side of seizure focus was significantly lower for the RTLE as compared with the LTLE group. Within- group differences in performance after ipsilateral as compared with contralateral injection were significant for the RTLE but not the LTLE group. The difference in interhemispheric asymmetry in IAP memory performance between RTLE and LTLE groups was reflected in decreased ability to classify LTLE patients as compared with RTLE patients about side of seizure onset, using a clinically applicable decision role. Conclusions: Recognition memory during the IAP for real objects, simultaneously named and presented visually during encoding, is mediated effectively by both the left and right hemisphere when there is no seizure focus present. However, memory appears to be more vulnerable to the presence of a seizure focus in the right as compared with the left hemisphere.",
author = "Breier, {J. I.} and Thomas, {A. B.} and Plenger, {P. M.} and James Wheless and Brookshire, {B. L.} and Andrew Papanicolaou and Willmore, {L. J.}",
year = "1997",
month = "11",
day = "1",
doi = "10.1111/j.1528-1157.1997.tb01218.x",
language = "English (US)",
volume = "38",
pages = "1209--1215",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Asymmetries in the effect of side of seizure onset on recognition memory following intracarotid amobarbital injection

AU - Breier, J. I.

AU - Thomas, A. B.

AU - Plenger, P. M.

AU - Wheless, James

AU - Brookshire, B. L.

AU - Papanicolaou, Andrew

AU - Willmore, L. J.

PY - 1997/11/1

Y1 - 1997/11/1

N2 - Purpose: To assess interhemispheric differences in recognition memory for objects during the intracarotid amobarbital sodium procedure (IAP). Methods: The recognition memory for real objects of patients with either right (RTLE; n = 28) or left (LTLE; n = 22) temporal lobe epilepsy was assessed at baseline, and after left and fight intracarotid amobarbital sodium injection. Results: There were no differences between groups on baseline performance. Performance following injection ipsilateral to the side of seizure focus was relatively lower for the LTLE as compared with the RTLE group, but this difference did not reach statistical significance. However, performance following injection contralateral to the side of seizure focus was significantly lower for the RTLE as compared with the LTLE group. Within- group differences in performance after ipsilateral as compared with contralateral injection were significant for the RTLE but not the LTLE group. The difference in interhemispheric asymmetry in IAP memory performance between RTLE and LTLE groups was reflected in decreased ability to classify LTLE patients as compared with RTLE patients about side of seizure onset, using a clinically applicable decision role. Conclusions: Recognition memory during the IAP for real objects, simultaneously named and presented visually during encoding, is mediated effectively by both the left and right hemisphere when there is no seizure focus present. However, memory appears to be more vulnerable to the presence of a seizure focus in the right as compared with the left hemisphere.

AB - Purpose: To assess interhemispheric differences in recognition memory for objects during the intracarotid amobarbital sodium procedure (IAP). Methods: The recognition memory for real objects of patients with either right (RTLE; n = 28) or left (LTLE; n = 22) temporal lobe epilepsy was assessed at baseline, and after left and fight intracarotid amobarbital sodium injection. Results: There were no differences between groups on baseline performance. Performance following injection ipsilateral to the side of seizure focus was relatively lower for the LTLE as compared with the RTLE group, but this difference did not reach statistical significance. However, performance following injection contralateral to the side of seizure focus was significantly lower for the RTLE as compared with the LTLE group. Within- group differences in performance after ipsilateral as compared with contralateral injection were significant for the RTLE but not the LTLE group. The difference in interhemispheric asymmetry in IAP memory performance between RTLE and LTLE groups was reflected in decreased ability to classify LTLE patients as compared with RTLE patients about side of seizure onset, using a clinically applicable decision role. Conclusions: Recognition memory during the IAP for real objects, simultaneously named and presented visually during encoding, is mediated effectively by both the left and right hemisphere when there is no seizure focus present. However, memory appears to be more vulnerable to the presence of a seizure focus in the right as compared with the left hemisphere.

UR - http://www.scopus.com/inward/record.url?scp=0030777545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030777545&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1157.1997.tb01218.x

DO - 10.1111/j.1528-1157.1997.tb01218.x

M3 - Article

VL - 38

SP - 1209

EP - 1215

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 11

ER -