Attenuation by acetaminophen of arachidonic acid-induced coronary vasolidation and output of prostaglandins in the isolated rat heart

Joel E. Shaffer, Lauren M. Cagen, Kafait Malik

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Abstract

We studied the effect of acetaminophen on the vascular actions of arachidonic acid and on the output of prostaglandins in the isolated rat heart. Arachidonic acid (33 nmol), administered as a bolus into the heart through the aortic cannula produced vasoconstriction followed by a long lasting vasolidation. Arachidonic acid also markedly increased the output of PGE2 and 6-keto-PGF from the heart. In the presence of acetaminophen (0.1-1.0 mM) both the output of prostaglandins and the duration of the coronary vasolidation were attenuated. We suggest that the major component of arachidonic acid-induced coronary vasolidation is mediated through prostaglandin synthesis and is blocked by acetaminophen.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalEuropean Journal of Pharmacology
Volume72
Issue number1
DOIs
StatePublished - Jun 10 1981

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Acetaminophen
Arachidonic Acid
Prostaglandins
Vasoconstriction
Dinoprostone
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Attenuation by acetaminophen of arachidonic acid-induced coronary vasolidation and output of prostaglandins in the isolated rat heart. / Shaffer, Joel E.; Cagen, Lauren M.; Malik, Kafait.

In: European Journal of Pharmacology, Vol. 72, No. 1, 10.06.1981, p. 57-61.

Research output: Contribution to journalArticle

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