Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature

Jean Christophe Cassel, Sami Ben Hamida, Byron Jones

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In rats, at ambient temperatures of 21-23 °C, ethanol can attenuate the hyperpyretic effects of MDMA. We assessed if this attenuation holds true at a high ambient temperature. Rats were given MDMA (6.6 mg/kg i.p.) with or without ethanol (1.5 g/kg i.p.) at a room temperature of 32 °C. In the MDMA and ethanol + MDMA rats, body temperatures rose to about 42 °C after 60 min; all these rats had died after 120 min. At 23 °C, however, there was no lethality and ethanol reduced the hyperthermia. Thus, the effects of ethanol on MDMA-induced hyperthermia are related to ambient temperature.

Original languageEnglish (US)
Pages (from-to)152-155
Number of pages4
JournalEuropean Journal of Pharmacology
Volume571
Issue number2-3
DOIs
StatePublished - Oct 1 2007
Externally publishedYes

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N-Methyl-3,4-methylenedioxyamphetamine
Induced Hyperthermia
Ethanol
Temperature
Body Temperature
Fever

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature. / Cassel, Jean Christophe; Hamida, Sami Ben; Jones, Byron.

In: European Journal of Pharmacology, Vol. 571, No. 2-3, 01.10.2007, p. 152-155.

Research output: Contribution to journalArticle

Cassel, Jean Christophe ; Hamida, Sami Ben ; Jones, Byron. / Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature. In: European Journal of Pharmacology. 2007 ; Vol. 571, No. 2-3. pp. 152-155.
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