Atypical language representation in patients with chronic seizure disorder and achievement deficits with magnetoencephalography

Joshua I. Breier, Edwardo M. Castillo, Panagiotis G. Simos, Rebecca L. Billingsley-Marshall, Ekaterina Pataraia, Shirin Sarkari, James Wheless, Andrew Papanicolaou

Research output: Contribution to journalArticle

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Abstract

Purpose: To characterize the relation between hemispheric asymmetries in language-specific brain activity and reading/spelling achievement by using magnetoencephalography (MEG). Methods: Patients (n = 83) with medically intractable complex partial seizures of either left- or right-hemisphere origin were classified as having reading and/or spelling deficits (RS) or as not impaired (NI) by using standard achievement tests. All patients had undergone noninvasive functional mapping of receptive language cortex by using MEG as part of a preoperative seizure surgery evaluation. Results: RS patients with left-hemisphere seizure onset exhibited relatively greater activation and earlier onset of late, language-specific MEG activity in posterior temporal and inferior parietal areas of the right as compared with the left hemisphere than did NI patients. These findings also were evident on an individual basis and were independent of global intellectual abilities. Conclusions: Reading and spelling achievement deficits in patients with complex partial seizures of left-hemisphere origin are associated with atypical language organization, possibly secondary to reorganization of language function to right-hemisphere areas that are not as efficient as homotopic areas in the left hemisphere in supporting reading and spelling functions.

Original languageEnglish (US)
Pages (from-to)540-548
Number of pages9
JournalEpilepsia
Volume46
Issue number4
DOIs
StatePublished - Apr 1 2005

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Magnetoencephalography
Epilepsy
Language
Reading
Seizures
Aptitude
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Breier, J. I., Castillo, E. M., Simos, P. G., Billingsley-Marshall, R. L., Pataraia, E., Sarkari, S., ... Papanicolaou, A. (2005). Atypical language representation in patients with chronic seizure disorder and achievement deficits with magnetoencephalography. Epilepsia, 46(4), 540-548. https://doi.org/10.1111/j.0013-9580.2005.48904.x

Atypical language representation in patients with chronic seizure disorder and achievement deficits with magnetoencephalography. / Breier, Joshua I.; Castillo, Edwardo M.; Simos, Panagiotis G.; Billingsley-Marshall, Rebecca L.; Pataraia, Ekaterina; Sarkari, Shirin; Wheless, James; Papanicolaou, Andrew.

In: Epilepsia, Vol. 46, No. 4, 01.04.2005, p. 540-548.

Research output: Contribution to journalArticle

Breier, JI, Castillo, EM, Simos, PG, Billingsley-Marshall, RL, Pataraia, E, Sarkari, S, Wheless, J & Papanicolaou, A 2005, 'Atypical language representation in patients with chronic seizure disorder and achievement deficits with magnetoencephalography', Epilepsia, vol. 46, no. 4, pp. 540-548. https://doi.org/10.1111/j.0013-9580.2005.48904.x
Breier, Joshua I. ; Castillo, Edwardo M. ; Simos, Panagiotis G. ; Billingsley-Marshall, Rebecca L. ; Pataraia, Ekaterina ; Sarkari, Shirin ; Wheless, James ; Papanicolaou, Andrew. / Atypical language representation in patients with chronic seizure disorder and achievement deficits with magnetoencephalography. In: Epilepsia. 2005 ; Vol. 46, No. 4. pp. 540-548.
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