Autoantibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNPA1) cause altered ‘ribostasis’ and neurodegeneration; the legacy of HAM/TSP as a model of progressive multiple sclerosis

Michael C. Levin, Sang Lee, Lidia A. Gardner, Yoojin Shin, Joshua N. Douglas, Hannah Salapa

Research output: Contribution to journalArticle

Abstract

Several years following its discovery in 1980, infection with human T-lymphotropic virus type 1 (HTLV-1) was shown to cause HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a disease biologically similar to progressive forms of multiple sclerosis (MS). In this manuscript, we review some of the clinical, pathological, and immunological similarities between HAM/TSP and MS with an emphasis on how autoantibodies to an RNA binding protein, heterogeneous nuclear ribonuclear protein A1 (hnRNP A1), might contribute to neurodegeneration in immune mediated diseases of the central nervous system.

Original languageEnglish (US)
Pages (from-to)56-62
Number of pages7
JournalJournal of Neuroimmunology
Volume304
DOIs
StatePublished - Mar 15 2017

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Tropical Spastic Paraparesis
Human T-lymphotropic virus 1
Spinal Cord Diseases
Nuclear Proteins
Autoantibodies
Multiple Sclerosis
RNA-Binding Proteins
Immune System Diseases
Central Nervous System
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Autoantibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNPA1) cause altered ‘ribostasis’ and neurodegeneration; the legacy of HAM/TSP as a model of progressive multiple sclerosis. / Levin, Michael C.; Lee, Sang; Gardner, Lidia A.; Shin, Yoojin; Douglas, Joshua N.; Salapa, Hannah.

In: Journal of Neuroimmunology, Vol. 304, 15.03.2017, p. 56-62.

Research output: Contribution to journalArticle

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