Autoimmune biomarkers in age-related macular degeneration

A possible role player in disease development and progression

Alessandro Iannaccone, Indira Neeli, Pratheebha Krishnamurthy, Nataliya I. Lenchik, Haibao Wan, Ivan Gerling, Dominic M. Desiderio, Marko Radic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

Age-related macular degeneration (AMD) is the leading cause of legal blindness among people over the age of 50. In recent years, a role for inflammation in the pathogenesis of both AMD in general and drusen in particular has been established at the biological, experimental, and genetic level. The purpose of this chapter is to (1) illustrate our rationale for the hypothesis that, in the aforementioned inflammatory context, auto-antibodies (auto-Abs) are biomarkers relevant to ocular disease status in AMD, based on a brief review of the literature; (2) present our preliminary data supporting this hypothesis from our ongoing investigations; and (3) propose a mechanistic framework for the formation of auto-Abs in AMD and their possible role in disease development and progression. Auto-Ab targets have the potential to be important disease biomarkers and may contribute significantly to AMD development and progression.

Original languageEnglish (US)
Title of host publicationRetinal Degenerative Diseases
Pages11-16
Number of pages6
DOIs
StatePublished - Jan 23 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume723
ISSN (Print)0065-2598

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Macular Degeneration
Biomarkers
Disease Progression
Antibodies
Eye Diseases
Blindness
Antibody Formation
Inflammation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Iannaccone, A., Neeli, I., Krishnamurthy, P., Lenchik, N. I., Wan, H., Gerling, I., ... Radic, M. (2012). Autoimmune biomarkers in age-related macular degeneration: A possible role player in disease development and progression. In Retinal Degenerative Diseases (pp. 11-16). (Advances in Experimental Medicine and Biology; Vol. 723). https://doi.org/10.1007/978-1-4614-0631-0_2

Autoimmune biomarkers in age-related macular degeneration : A possible role player in disease development and progression. / Iannaccone, Alessandro; Neeli, Indira; Krishnamurthy, Pratheebha; Lenchik, Nataliya I.; Wan, Haibao; Gerling, Ivan; Desiderio, Dominic M.; Radic, Marko.

Retinal Degenerative Diseases. 2012. p. 11-16 (Advances in Experimental Medicine and Biology; Vol. 723).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Iannaccone, A, Neeli, I, Krishnamurthy, P, Lenchik, NI, Wan, H, Gerling, I, Desiderio, DM & Radic, M 2012, Autoimmune biomarkers in age-related macular degeneration: A possible role player in disease development and progression. in Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol. 723, pp. 11-16. https://doi.org/10.1007/978-1-4614-0631-0_2
Iannaccone A, Neeli I, Krishnamurthy P, Lenchik NI, Wan H, Gerling I et al. Autoimmune biomarkers in age-related macular degeneration: A possible role player in disease development and progression. In Retinal Degenerative Diseases. 2012. p. 11-16. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-0631-0_2
Iannaccone, Alessandro ; Neeli, Indira ; Krishnamurthy, Pratheebha ; Lenchik, Nataliya I. ; Wan, Haibao ; Gerling, Ivan ; Desiderio, Dominic M. ; Radic, Marko. / Autoimmune biomarkers in age-related macular degeneration : A possible role player in disease development and progression. Retinal Degenerative Diseases. 2012. pp. 11-16 (Advances in Experimental Medicine and Biology).
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