Autosomal similarity revealed by eukaryotic genomic comparison

Zhen Qi, Yan Cui, Weiwu Fang, Lunjiang Ling, Runsheng Chen

Research output: Contribution to journalArticle

Abstract

To describe eukaryotic autosomes quantitatively and determine differences between them in terms of amino acid sequences of genes, functional classification of proteins, and complete DNA sequences, we applied two theoretical methods, the Proteome-vector method and the function of degree of disagreement (FDOD) method, that are based on function and sequence similarity respectively, to autosomes from nine eukaryotes. No matter what aspect of the autosome is considered, the autosomal differences within each organism were less than that between species. Our results show that eukaryotic autosomes resemble each other within a species while those from different organisms differ. We propose a hypothesis (named intra-species autosomal random shuffling) as an explanation for our results and suggest that lateral gene transfer (LGT) did not occur frequently during the evolution of eukarya.

Original languageEnglish (US)
Pages (from-to)305-312
Number of pages8
JournalJournal of Biological Physics
Volume30
Issue number4
DOIs
StatePublished - Dec 1 2004

Fingerprint

organisms
genes
proteome
eukaryotes
Eukaryota
amino acids
Horizontal Gene Transfer
deoxyribonucleic acid
Proteome
proteins
Amino Acid Sequence
Genes
Proteins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Atomic and Molecular Physics, and Optics
  • Molecular Biology
  • Cell Biology

Cite this

Autosomal similarity revealed by eukaryotic genomic comparison. / Qi, Zhen; Cui, Yan; Fang, Weiwu; Ling, Lunjiang; Chen, Runsheng.

In: Journal of Biological Physics, Vol. 30, No. 4, 01.12.2004, p. 305-312.

Research output: Contribution to journalArticle

Qi, Zhen ; Cui, Yan ; Fang, Weiwu ; Ling, Lunjiang ; Chen, Runsheng. / Autosomal similarity revealed by eukaryotic genomic comparison. In: Journal of Biological Physics. 2004 ; Vol. 30, No. 4. pp. 305-312.
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