B cells and atherosclerosis

Prasad Srikakulapu, Coleen A. McNamara

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

B cells have emerged as important immune cells in cardiovascular disease. Initial studies have suggested that B cells protect against atherosclerosis development. However, subsequent studies demonstrating aggravation of atherosclerosis by B-2 cells have shed light on the subset-dependent effects of B cells. Here, we review the literature that has led to our current understanding of B cell regulation of atherosclerosis, touching on the importance of subsets, local regulation, human translation, and therapeutic potential.

Original languageEnglish (US)
Pages (from-to)H1060-H1067
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume312
Issue number5
DOIs
StatePublished - May 15 2017

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Atherosclerosis
B-Lymphocytes
Cardiovascular Diseases
Therapeutics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

B cells and atherosclerosis. / Srikakulapu, Prasad; McNamara, Coleen A.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 312, No. 5, 15.05.2017, p. H1060-H1067.

Research output: Contribution to journalReview article

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