Bacterial inhibition by chitosan coatings loaded with silver-decorated calcium phosphate microspheres

Jessica Amber Jennings, Diego A. Velasquez Pulgarin, Dom Lal Kunwar, Jegdish Babu, Sanjay Mishra, Joel Bumgardner

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Porous calcium phosphate microspheres have been modified to contain nanoparticles of silver to provide both osteoconductive and antimicrobial components to implant coatings. These microspheres have been mixed with chitosan and bonded to titanium via alkyloxysilane reaction. Silver concentration on calcium phosphate microspheres was varied from 0 to 50% and microspheres were loaded at 30 wt.% within chitosan coatings. Increasing concentrations of silver loaded on calcium phosphate microspheres within the chemically bound coating reduces bacterial viability by up to 90% in both anaerobic and aerobic pathogenic microorganisms, including Staphylococcus aureus, Prevotella denticola, and Porphyromonas gingivalis. This novel coating could reduce the incidence of infection in orthopaedic and dental implant applications.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalThin Solid Films
Volume596
DOIs
StatePublished - Dec 1 2015

Fingerprint

calcium phosphates
Calcium phosphate
Chitosan
Microspheres
Silver
silver
coatings
Coatings
orthopedics
staphylococcus
infectious diseases
microorganisms
Dental prostheses
viability
Orthopedics
Titanium
titanium
incidence
Microorganisms
nanoparticles

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Jennings, J. A., Velasquez Pulgarin, D. A., Kunwar, D. L., Babu, J., Mishra, S., & Bumgardner, J. (2015). Bacterial inhibition by chitosan coatings loaded with silver-decorated calcium phosphate microspheres. Thin Solid Films, 596, 83-86. https://doi.org/10.1016/j.tsf.2015.08.060

Bacterial inhibition by chitosan coatings loaded with silver-decorated calcium phosphate microspheres. / Jennings, Jessica Amber; Velasquez Pulgarin, Diego A.; Kunwar, Dom Lal; Babu, Jegdish; Mishra, Sanjay; Bumgardner, Joel.

In: Thin Solid Films, Vol. 596, 01.12.2015, p. 83-86.

Research output: Contribution to journalArticle

Jennings, Jessica Amber ; Velasquez Pulgarin, Diego A. ; Kunwar, Dom Lal ; Babu, Jegdish ; Mishra, Sanjay ; Bumgardner, Joel. / Bacterial inhibition by chitosan coatings loaded with silver-decorated calcium phosphate microspheres. In: Thin Solid Films. 2015 ; Vol. 596. pp. 83-86.
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