Bacterial sinusitis and otitis media following influenza virus infection in ferrets

Ville T. Peltola, Kelli L. Boyd, Julie L. McAuley, Jerold E. Rehg, Jonathan Mccullers

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Streptococcus pneumoniae is the leading cause of otitis media, sinusitis, and pneumonia. Many of these infections result from antecedent influenza virus infections. In this study we sought to determine whether the frequency and character of secondary pneumococcal infections differed depending on the strain of influenza virus that preceded bacterial challenge. In young ferrets infected with influenza virus and then challenged with pneumococcus, influenza viruses of any subtype increased bacterial colonization of the nasopharynx. Nine out of 10 ferrets infected with H3N2 subtype influenza A viruses developed either sinusitis or otitis media, while only 1 out of 11 ferrets infected with either an H1N1 influenza A virus or an influenza B virus did so. These data may partially explain why bacterial complication rates are higher during seasons when H3N2 viruses predominate. This animal model will be useful for further study of the mechanisms that underlie viral-bacterial synergism.

Original languageEnglish (US)
Pages (from-to)2562-2567
Number of pages6
JournalInfection and Immunity
Volume74
Issue number5
DOIs
StatePublished - May 1 2006

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Ferrets
Sinusitis
Otitis Media
Virus Diseases
Orthomyxoviridae
H3N2 Subtype Influenza A Virus
Streptococcus pneumoniae
Influenza B virus
Pneumococcal Infections
H1N1 Subtype Influenza A Virus
Nasopharynx
Influenza A virus
Coinfection
Pneumonia
Animal Models
Infection

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Bacterial sinusitis and otitis media following influenza virus infection in ferrets. / Peltola, Ville T.; Boyd, Kelli L.; McAuley, Julie L.; Rehg, Jerold E.; Mccullers, Jonathan.

In: Infection and Immunity, Vol. 74, No. 5, 01.05.2006, p. 2562-2567.

Research output: Contribution to journalArticle

Peltola, Ville T. ; Boyd, Kelli L. ; McAuley, Julie L. ; Rehg, Jerold E. ; Mccullers, Jonathan. / Bacterial sinusitis and otitis media following influenza virus infection in ferrets. In: Infection and Immunity. 2006 ; Vol. 74, No. 5. pp. 2562-2567.
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