Baseline age and time to major fracture in younger postmenopausal women

Margaret Lee Gourlay, Robert A. Overman, Jason P. Fine, Kristine E. Ensrud, Carolyn J. Crandall, Margery L. Gass, John Robbins, Karen Johnson, Erin S. Leblanc, Catherine Womack, John T. Schousboe, Andrea Z. Lacroix

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study aims to estimate the incidence of first hip or clinical vertebral fracture or major osteoporotic (hip, clinical vertebral, proximal humerus, or wrist) fracture in postmenopausal women undergoing their first bone mineral density (BMD) test before age 65 years. Methods We studied 4,068 postmenopausal women, aged 50 to 64 years without hip or clinical vertebral fracture or antifracture treatment at baseline, who were participating in the Women's Health Initiative BMD cohort study. BMD tests were performed between October 1993 and April 2005, with fracture follow-up through 2012. Outcomes were the time for 1% of women to sustain a hip or clinical vertebral fracture and the time for 3% of women to sustain a major osteoporotic fracture before initiating treatment, adjusting for clinical risk factors and accounting for competing risks. Women without osteoporosis and women with osteoporosis on their first BMD test were analyzed separately. Results During a maximum of 11.2 years of concurrent BMD and fracture follow-up, the adjusted estimated time for 1% of women to have a hip or clinical vertebral fracture was 12.8 years (95% CI, 8.0-20.4) for women aged 50 to 54 years without baseline osteoporosis, 7.6 years (95% CI, 4.8-12.1) for women aged 60 to 64 years without baseline osteoporosis, and 3.0 years (95% CI, 1.3-7.1) for all women aged 50 to 64 years with baseline osteoporosis. Results for major osteoporotic fracture were similar. Conclusions Because of very low rates of major osteoporotic fracture, postmenopausal women aged 50 to 64 years without osteoporosis on their first BMD test are unlikely to benefit from frequent rescreening before age 65 years.

Original languageEnglish (US)
Pages (from-to)589-597
Number of pages9
JournalMenopause
Volume22
Issue number6
DOIs
StatePublished - Jun 6 2015

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Bone Density
Osteoporosis
Hip
Osteoporotic Fractures
Humerus
Bone Fractures
Women's Health
Wrist
Cohort Studies
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Gourlay, M. L., Overman, R. A., Fine, J. P., Ensrud, K. E., Crandall, C. J., Gass, M. L., ... Lacroix, A. Z. (2015). Baseline age and time to major fracture in younger postmenopausal women. Menopause, 22(6), 589-597. https://doi.org/10.1097/GME.0000000000000356

Baseline age and time to major fracture in younger postmenopausal women. / Gourlay, Margaret Lee; Overman, Robert A.; Fine, Jason P.; Ensrud, Kristine E.; Crandall, Carolyn J.; Gass, Margery L.; Robbins, John; Johnson, Karen; Leblanc, Erin S.; Womack, Catherine; Schousboe, John T.; Lacroix, Andrea Z.

In: Menopause, Vol. 22, No. 6, 06.06.2015, p. 589-597.

Research output: Contribution to journalArticle

Gourlay, ML, Overman, RA, Fine, JP, Ensrud, KE, Crandall, CJ, Gass, ML, Robbins, J, Johnson, K, Leblanc, ES, Womack, C, Schousboe, JT & Lacroix, AZ 2015, 'Baseline age and time to major fracture in younger postmenopausal women', Menopause, vol. 22, no. 6, pp. 589-597. https://doi.org/10.1097/GME.0000000000000356
Gourlay ML, Overman RA, Fine JP, Ensrud KE, Crandall CJ, Gass ML et al. Baseline age and time to major fracture in younger postmenopausal women. Menopause. 2015 Jun 6;22(6):589-597. https://doi.org/10.1097/GME.0000000000000356
Gourlay, Margaret Lee ; Overman, Robert A. ; Fine, Jason P. ; Ensrud, Kristine E. ; Crandall, Carolyn J. ; Gass, Margery L. ; Robbins, John ; Johnson, Karen ; Leblanc, Erin S. ; Womack, Catherine ; Schousboe, John T. ; Lacroix, Andrea Z. / Baseline age and time to major fracture in younger postmenopausal women. In: Menopause. 2015 ; Vol. 22, No. 6. pp. 589-597.
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abstract = "This study aims to estimate the incidence of first hip or clinical vertebral fracture or major osteoporotic (hip, clinical vertebral, proximal humerus, or wrist) fracture in postmenopausal women undergoing their first bone mineral density (BMD) test before age 65 years. Methods We studied 4,068 postmenopausal women, aged 50 to 64 years without hip or clinical vertebral fracture or antifracture treatment at baseline, who were participating in the Women's Health Initiative BMD cohort study. BMD tests were performed between October 1993 and April 2005, with fracture follow-up through 2012. Outcomes were the time for 1{\%} of women to sustain a hip or clinical vertebral fracture and the time for 3{\%} of women to sustain a major osteoporotic fracture before initiating treatment, adjusting for clinical risk factors and accounting for competing risks. Women without osteoporosis and women with osteoporosis on their first BMD test were analyzed separately. Results During a maximum of 11.2 years of concurrent BMD and fracture follow-up, the adjusted estimated time for 1{\%} of women to have a hip or clinical vertebral fracture was 12.8 years (95{\%} CI, 8.0-20.4) for women aged 50 to 54 years without baseline osteoporosis, 7.6 years (95{\%} CI, 4.8-12.1) for women aged 60 to 64 years without baseline osteoporosis, and 3.0 years (95{\%} CI, 1.3-7.1) for all women aged 50 to 64 years with baseline osteoporosis. Results for major osteoporotic fracture were similar. Conclusions Because of very low rates of major osteoporotic fracture, postmenopausal women aged 50 to 64 years without osteoporosis on their first BMD test are unlikely to benefit from frequent rescreening before age 65 years.",
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AU - Robbins, John

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AU - Schousboe, John T.

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N2 - This study aims to estimate the incidence of first hip or clinical vertebral fracture or major osteoporotic (hip, clinical vertebral, proximal humerus, or wrist) fracture in postmenopausal women undergoing their first bone mineral density (BMD) test before age 65 years. Methods We studied 4,068 postmenopausal women, aged 50 to 64 years without hip or clinical vertebral fracture or antifracture treatment at baseline, who were participating in the Women's Health Initiative BMD cohort study. BMD tests were performed between October 1993 and April 2005, with fracture follow-up through 2012. Outcomes were the time for 1% of women to sustain a hip or clinical vertebral fracture and the time for 3% of women to sustain a major osteoporotic fracture before initiating treatment, adjusting for clinical risk factors and accounting for competing risks. Women without osteoporosis and women with osteoporosis on their first BMD test were analyzed separately. Results During a maximum of 11.2 years of concurrent BMD and fracture follow-up, the adjusted estimated time for 1% of women to have a hip or clinical vertebral fracture was 12.8 years (95% CI, 8.0-20.4) for women aged 50 to 54 years without baseline osteoporosis, 7.6 years (95% CI, 4.8-12.1) for women aged 60 to 64 years without baseline osteoporosis, and 3.0 years (95% CI, 1.3-7.1) for all women aged 50 to 64 years with baseline osteoporosis. Results for major osteoporotic fracture were similar. Conclusions Because of very low rates of major osteoporotic fracture, postmenopausal women aged 50 to 64 years without osteoporosis on their first BMD test are unlikely to benefit from frequent rescreening before age 65 years.

AB - This study aims to estimate the incidence of first hip or clinical vertebral fracture or major osteoporotic (hip, clinical vertebral, proximal humerus, or wrist) fracture in postmenopausal women undergoing their first bone mineral density (BMD) test before age 65 years. Methods We studied 4,068 postmenopausal women, aged 50 to 64 years without hip or clinical vertebral fracture or antifracture treatment at baseline, who were participating in the Women's Health Initiative BMD cohort study. BMD tests were performed between October 1993 and April 2005, with fracture follow-up through 2012. Outcomes were the time for 1% of women to sustain a hip or clinical vertebral fracture and the time for 3% of women to sustain a major osteoporotic fracture before initiating treatment, adjusting for clinical risk factors and accounting for competing risks. Women without osteoporosis and women with osteoporosis on their first BMD test were analyzed separately. Results During a maximum of 11.2 years of concurrent BMD and fracture follow-up, the adjusted estimated time for 1% of women to have a hip or clinical vertebral fracture was 12.8 years (95% CI, 8.0-20.4) for women aged 50 to 54 years without baseline osteoporosis, 7.6 years (95% CI, 4.8-12.1) for women aged 60 to 64 years without baseline osteoporosis, and 3.0 years (95% CI, 1.3-7.1) for all women aged 50 to 64 years with baseline osteoporosis. Results for major osteoporotic fracture were similar. Conclusions Because of very low rates of major osteoporotic fracture, postmenopausal women aged 50 to 64 years without osteoporosis on their first BMD test are unlikely to benefit from frequent rescreening before age 65 years.

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