Baseline mannose binding lectin levels may not predict infection among children with leukemia

Jeffrey E. Rubnitz, Scott Howard, Jennifer Willis, Ching Hon Pui, Stanley Pounds, Randall T. Hayden

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We measured baseline serum mannose binding lectin (MBL) levels in 91 patients with childhood leukemia to determine their predictive value for the development of febrile neutropenia or specific infections. Median MBL levels did not differ significantly between patients who developed febrile neutropenia, bacterial infection, or disseminated fungal infection and those who did not. In addition, low MBL levels were not associated with an increased cumulative incidence of infection or with a shorter time to first infection. This preliminary study suggests that baseline MBL levels may not be clinically useful to identify pediatric leukemia patients who are at increased risk of infection. Additional studies are required to determine whether serial MBL measurements may be valuable for this purpose.

Original languageEnglish (US)
Pages (from-to)866-868
Number of pages3
JournalPediatric Blood and Cancer
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2008

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Mannose-Binding Lectin
Leukemia
Infection
Febrile Neutropenia
Mycoses
Bacterial Infections
Pediatrics
Incidence
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Baseline mannose binding lectin levels may not predict infection among children with leukemia. / Rubnitz, Jeffrey E.; Howard, Scott; Willis, Jennifer; Pui, Ching Hon; Pounds, Stanley; Hayden, Randall T.

In: Pediatric Blood and Cancer, Vol. 50, No. 4, 01.04.2008, p. 866-868.

Research output: Contribution to journalArticle

Rubnitz, Jeffrey E. ; Howard, Scott ; Willis, Jennifer ; Pui, Ching Hon ; Pounds, Stanley ; Hayden, Randall T. / Baseline mannose binding lectin levels may not predict infection among children with leukemia. In: Pediatric Blood and Cancer. 2008 ; Vol. 50, No. 4. pp. 866-868.
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