Basic amino acid inhibition of growth in Saccharomyces cerevisiae

Roberta Sumrada, Terrance Cooper

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Growth of Saccharomyces cerevisiae on poor nitrogen sources such as allantoin or proline is totally inhibited by addition of lysine to the medium. The same result is observed with ornithine if its degradation to glutamic semialdehyde is prevented. Since inhibition occurs even when arginine is used as nitrogen source it is not likely that cessation of growth is due to arginine limitation as previously suggested. Preliminary observations suggest that addition of basic amino acids to slowly growing cultures of Saccharomyces inhibits some process associated with the cell cycle.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume68
Issue number2
DOIs
StatePublished - Jan 26 1976
Externally publishedYes

Fingerprint

Basic Amino Acids
Yeast
Saccharomyces cerevisiae
Arginine
Nitrogen
Allantoin
Saccharomyces
Ornithine
Growth
Proline
Lysine
Cell Cycle
Cells
Degradation

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Basic amino acid inhibition of growth in Saccharomyces cerevisiae. / Sumrada, Roberta; Cooper, Terrance.

In: Biochemical and Biophysical Research Communications, Vol. 68, No. 2, 26.01.1976, p. 598-602.

Research output: Contribution to journalArticle

@article{d591e6dd454b48c1b34ba5ff63857f50,
title = "Basic amino acid inhibition of growth in Saccharomyces cerevisiae",
abstract = "Growth of Saccharomyces cerevisiae on poor nitrogen sources such as allantoin or proline is totally inhibited by addition of lysine to the medium. The same result is observed with ornithine if its degradation to glutamic semialdehyde is prevented. Since inhibition occurs even when arginine is used as nitrogen source it is not likely that cessation of growth is due to arginine limitation as previously suggested. Preliminary observations suggest that addition of basic amino acids to slowly growing cultures of Saccharomyces inhibits some process associated with the cell cycle.",
author = "Roberta Sumrada and Terrance Cooper",
year = "1976",
month = "1",
day = "26",
doi = "10.1016/0006-291X(76)91187-6",
language = "English (US)",
volume = "68",
pages = "598--602",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Basic amino acid inhibition of growth in Saccharomyces cerevisiae

AU - Sumrada, Roberta

AU - Cooper, Terrance

PY - 1976/1/26

Y1 - 1976/1/26

N2 - Growth of Saccharomyces cerevisiae on poor nitrogen sources such as allantoin or proline is totally inhibited by addition of lysine to the medium. The same result is observed with ornithine if its degradation to glutamic semialdehyde is prevented. Since inhibition occurs even when arginine is used as nitrogen source it is not likely that cessation of growth is due to arginine limitation as previously suggested. Preliminary observations suggest that addition of basic amino acids to slowly growing cultures of Saccharomyces inhibits some process associated with the cell cycle.

AB - Growth of Saccharomyces cerevisiae on poor nitrogen sources such as allantoin or proline is totally inhibited by addition of lysine to the medium. The same result is observed with ornithine if its degradation to glutamic semialdehyde is prevented. Since inhibition occurs even when arginine is used as nitrogen source it is not likely that cessation of growth is due to arginine limitation as previously suggested. Preliminary observations suggest that addition of basic amino acids to slowly growing cultures of Saccharomyces inhibits some process associated with the cell cycle.

UR - http://www.scopus.com/inward/record.url?scp=0017285309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017285309&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(76)91187-6

DO - 10.1016/0006-291X(76)91187-6

M3 - Article

VL - 68

SP - 598

EP - 602

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -