Bayesian network webserver

A comprehensive tool for biological network modeling

Jesse D. Ziebarth, Anindya Bhattacharya, Yan Cui

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Summary: The Bayesian Network Webserver (BNW) is a platform for comprehensive network modeling of systems genetics and other biological datasets. It allows users to quickly and seamlessly upload a dataset, learn the structure of the network model that best explains the data and use the model to understand relationships between network variables. Many datasets, including those used to create genetic network models, contain both discrete (e.g. genotype) and continuous (e.g. gene expression traits) variables, and BNW allows for modeling hybrid datasets. Users of BNW can incorporate prior knowledge during structure learning through an easy-to-use structural constraint interface. After structure learning, users are immediately presented with an interactive network model, which can be used to make testable hypotheses about network relationships. Availability and implementation: BNW, including a downloadable structure learning package, is available at http://compbio.uthsc. edu/BNW. (The BNW interface for adding structural constraints uses HTML5 features that are not supported by current version of Internet Explorer. We suggest using other browsers (e.g. Google Chrome or Mozilla Firefox) when accessing BNW).

Original languageEnglish (US)
Pages (from-to)2801-2803
Number of pages3
JournalBioinformatics
Volume29
Issue number21
DOIs
StatePublished - Nov 1 2013

Fingerprint

Network Modeling
Biological Networks
Web Server
Bayesian networks
Bayesian Networks
Learning
Structure Learning
Network Model
Genetic Models
Internet
Hybrid Modeling
Genotype
Genetic Network
Gene Expression
Datasets
Prior Knowledge
Gene expression
Interfaces (computer)
Immediately
Availability

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

Cite this

Bayesian network webserver : A comprehensive tool for biological network modeling. / Ziebarth, Jesse D.; Bhattacharya, Anindya; Cui, Yan.

In: Bioinformatics, Vol. 29, No. 21, 01.11.2013, p. 2801-2803.

Research output: Contribution to journalArticle

Ziebarth, Jesse D. ; Bhattacharya, Anindya ; Cui, Yan. / Bayesian network webserver : A comprehensive tool for biological network modeling. In: Bioinformatics. 2013 ; Vol. 29, No. 21. pp. 2801-2803.
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