Behavioral specificity of the bitter taste gene soa

John Boughter, Glayde Whitney

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In mice, aversion to the bitter acetylated sugar sucrose octaacetate (SOA) is determined by a single genetic locus with three alleles. SWR/J (SW) inbred mice are SOA tasters: They avoid many compounds characterized as bitter-tasting by humans, at concentrations to which C3HeB/FeJ (C3:SOA demitasters) mice are less sensitive. C3.SW-Soaa congenic taster mice contain the taster allele transposed to a 99% C3 bitter-insensitive genetic background. SW, C3, C3.SW-Soaa congenic taster, and C3.SW demitaster mice were behaviorally tested with a series of 48-h two-bottle preference tests to determine the influence of the Soaa taster allele on sensitivity to a variety of bitter-tasting compounds. Son allelic variation had a major effect on sensitivity to 0.003-1.0 mM SOA and several concentrations of the bitter-tasting alkaloids brucine, strychnine, and quinine. Effects were also found for 0.1 mM denatonium and 1 mM propylthiouracil. For caffeine, cycloheximide, thiamine, and two nonbitter compounds (NaCl and calcium hydroxide), the SW mice avoided lower concentrations than the other strains, but this avoidance was not due to the Soaa allele because both the C3 inbred and C3.SW-Soaa congenics were less sensitive. These results suggest the Son gene product influences sensitivity to a subset of bitter-tasting compounds.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalPhysiology and Behavior
Volume63
Issue number1
DOIs
StatePublished - Dec 31 1997

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Alleles
Genes
Congenic Mice
Calcium Hydroxide
Propylthiouracil
Strychnine
Genetic Loci
Quinine
Thiamine
Cycloheximide
Caffeine
Alkaloids
sucrose octaacetate

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Behavioral specificity of the bitter taste gene soa. / Boughter, John; Whitney, Glayde.

In: Physiology and Behavior, Vol. 63, No. 1, 31.12.1997, p. 101-108.

Research output: Contribution to journalArticle

Boughter, John ; Whitney, Glayde. / Behavioral specificity of the bitter taste gene soa. In: Physiology and Behavior. 1997 ; Vol. 63, No. 1. pp. 101-108.
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