Bence-Jones Proteins and Light Chains of Immunoglobulins

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Role of the Light Chain in the Antibody-Combining Site Recombination and affinity-labeling experiments have provided evidence that both heavy and light chains are required for antibody activity, a finding indicating that each chain contributes to the antigen-binding site.45However, data derived from hapten-binding and viral neutralization studies indicate activity expressed individually by heavy chains and light chains, respectively979899100101and suggest that this phenomenon depends, in part, on the fact that either chain can exist in the dimeric form.100101The postulation100that each species in the dimer interacts in a manner analogous to the heavy-light chain interaction to form the antibody-combining.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalNew England Journal of Medicine
Volume294
Issue number2
DOIs
StatePublished - Jan 8 1976

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Bence Jones Protein
Immunoglobulin Light Chains
Light
Antibodies
Haptens
Genetic Recombination
Binding Sites
Antigens

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Bence-Jones Proteins and Light Chains of Immunoglobulins. / Solomon, Alan.

In: New England Journal of Medicine, Vol. 294, No. 2, 08.01.1976, p. 91-98.

Research output: Contribution to journalReview article

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