Beneficial effects of propranolol and digitalis on contraction and S-T segment elevation after acute coronary occlusion

Surrender Raina, Vidya S. Banka, K Ramanathan, Monty M. Bodenheimer, Richard H. Helfant

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Propranolol and digitalis each have limltations in acute myocardial infarction, the former because of negative inotropic effects and the latter because of increased ischemia. To evaluate their combined effects, ouabain (in a priming dose of 7.5 μg/kg body weight followed by 2 to 3 μg/kg per min intravenous infusion) and propranolol (1 mg/kg intravenously) were administered randomly in 22 open chest dogs after acute coronary occlusion, and changes were observed in epicardial S-T segment (10 to 14 sites) and local tension (strain gauge measurements). Heart rate was controlled by atrial pacing. After acute coronary occlusion, tension in the nonischemic zone decreased to 92.8 ± 3.4 percent of control level. Propranolol reduced It further to 67.3 ± 4.9 percent (P < 0.005), but ouabain increased it to 92.9 ± 4.9 percent (P < 0.005). Tension in the border zone decreased to 84.9 ± 4.11 percent (P < 0.005) after acute occlusion and to 54.5 ± 5.5 percent (P < 0.001) with propranolol but increased to 73.6 ± 5.1 percent (P < 0.005) with ouabain. Tension in the ischemic zone decreased from 59.3 ± 5.5 percent to 45.8 ± 5.0 percent (P < 0.001) with propranolol but was unaffected by ouabain. The sum of S-T elevation, which increased from 27.8 ± 5.3 to 72.1 ± 10.8 mv after occlusion, decreased to 62.8 ± 11.8 mv (P < 0.05) with propranolol and further to 53.0 ± 10.4 mv (P < 0.005) with ouabain. The pattern of changes in average S-T elevation was similar. When propranolol administration followed ouabain infusion, essentially similar effects on tension and the sum of S-T and average S-T elevation were observed. In summary, the combination of propranolol and digitalls favorably affects both tension and S-T segment abnormalities after acute coronary occlusion.

Original languageEnglish (US)
Pages (from-to)226-233
Number of pages8
JournalThe American Journal of Cardiology
Volume42
Issue number2
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

Fingerprint

Digitalis
Coronary Occlusion
Propranolol
Ouabain
Intravenous Infusions
Thorax
Ischemia
Heart Rate
Myocardial Infarction
Body Weight
Dogs

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Beneficial effects of propranolol and digitalis on contraction and S-T segment elevation after acute coronary occlusion. / Raina, Surrender; Banka, Vidya S.; Ramanathan, K; Bodenheimer, Monty M.; Helfant, Richard H.

In: The American Journal of Cardiology, Vol. 42, No. 2, 01.01.1978, p. 226-233.

Research output: Contribution to journalArticle

Raina, Surrender ; Banka, Vidya S. ; Ramanathan, K ; Bodenheimer, Monty M. ; Helfant, Richard H. / Beneficial effects of propranolol and digitalis on contraction and S-T segment elevation after acute coronary occlusion. In: The American Journal of Cardiology. 1978 ; Vol. 42, No. 2. pp. 226-233.
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abstract = "Propranolol and digitalis each have limltations in acute myocardial infarction, the former because of negative inotropic effects and the latter because of increased ischemia. To evaluate their combined effects, ouabain (in a priming dose of 7.5 μg/kg body weight followed by 2 to 3 μg/kg per min intravenous infusion) and propranolol (1 mg/kg intravenously) were administered randomly in 22 open chest dogs after acute coronary occlusion, and changes were observed in epicardial S-T segment (10 to 14 sites) and local tension (strain gauge measurements). Heart rate was controlled by atrial pacing. After acute coronary occlusion, tension in the nonischemic zone decreased to 92.8 ± 3.4 percent of control level. Propranolol reduced It further to 67.3 ± 4.9 percent (P < 0.005), but ouabain increased it to 92.9 ± 4.9 percent (P < 0.005). Tension in the border zone decreased to 84.9 ± 4.11 percent (P < 0.005) after acute occlusion and to 54.5 ± 5.5 percent (P < 0.001) with propranolol but increased to 73.6 ± 5.1 percent (P < 0.005) with ouabain. Tension in the ischemic zone decreased from 59.3 ± 5.5 percent to 45.8 ± 5.0 percent (P < 0.001) with propranolol but was unaffected by ouabain. The sum of S-T elevation, which increased from 27.8 ± 5.3 to 72.1 ± 10.8 mv after occlusion, decreased to 62.8 ± 11.8 mv (P < 0.05) with propranolol and further to 53.0 ± 10.4 mv (P < 0.005) with ouabain. The pattern of changes in average S-T elevation was similar. When propranolol administration followed ouabain infusion, essentially similar effects on tension and the sum of S-T and average S-T elevation were observed. In summary, the combination of propranolol and digitalls favorably affects both tension and S-T segment abnormalities after acute coronary occlusion.",
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N2 - Propranolol and digitalis each have limltations in acute myocardial infarction, the former because of negative inotropic effects and the latter because of increased ischemia. To evaluate their combined effects, ouabain (in a priming dose of 7.5 μg/kg body weight followed by 2 to 3 μg/kg per min intravenous infusion) and propranolol (1 mg/kg intravenously) were administered randomly in 22 open chest dogs after acute coronary occlusion, and changes were observed in epicardial S-T segment (10 to 14 sites) and local tension (strain gauge measurements). Heart rate was controlled by atrial pacing. After acute coronary occlusion, tension in the nonischemic zone decreased to 92.8 ± 3.4 percent of control level. Propranolol reduced It further to 67.3 ± 4.9 percent (P < 0.005), but ouabain increased it to 92.9 ± 4.9 percent (P < 0.005). Tension in the border zone decreased to 84.9 ± 4.11 percent (P < 0.005) after acute occlusion and to 54.5 ± 5.5 percent (P < 0.001) with propranolol but increased to 73.6 ± 5.1 percent (P < 0.005) with ouabain. Tension in the ischemic zone decreased from 59.3 ± 5.5 percent to 45.8 ± 5.0 percent (P < 0.001) with propranolol but was unaffected by ouabain. The sum of S-T elevation, which increased from 27.8 ± 5.3 to 72.1 ± 10.8 mv after occlusion, decreased to 62.8 ± 11.8 mv (P < 0.05) with propranolol and further to 53.0 ± 10.4 mv (P < 0.005) with ouabain. The pattern of changes in average S-T elevation was similar. When propranolol administration followed ouabain infusion, essentially similar effects on tension and the sum of S-T and average S-T elevation were observed. In summary, the combination of propranolol and digitalls favorably affects both tension and S-T segment abnormalities after acute coronary occlusion.

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