Bile reflux gastritis

F. J. Bondurant, K. I. Maull, Henry Nelson, S. H. Silver

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Bile reflux gastritis is a disabling postgastrectomy condition characterized by abdominal pain, bilious vomiting, and weight loss. The syndrome appears to be caused by free enterogastric reflux of bile and other proximal small bowel constituents. Endoscopic confirmation of bile reflux and documentation of gastritis support the diagnosis but are not specific for it. Results of medical therapy with chelating agents or drugs that promote gastric motility have been disappointing. Diet and antacids frequently aggravate symptoms. The only effective treatment is surgical diversion of bile away from the gastric mucosa. During a recent seven-year period, 15 patients had diversionary operation for bile reflux gastritis diagnosed by history and endoscopic findings. Before operation, medical management had failed to yield improvment in any case. After operation, all patients showed improvement, and pain was relieved in 85%. Based on our experience, we conclude that (1) current medical therapy may alter but not cure symptoms of bile reflux gastritis; (2) Roux-en-Y diversion is the treatment of choice in patients with persistent symptoms; and (3) delayed gastric emptying is a common complication after the Roux-en-Y procedure, but in our series, the incidence was reduced by using the Tanner 19 modification. New cytoprotective agents that may offer an alternative to operation are currently being studied.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalSouthern Medical Journal
Volume80
Issue number2
DOIs
StatePublished - Jan 1 1987

Fingerprint

Bile Reflux
Gastritis
Roux-en-Y Anastomosis
Gastrointestinal Agents
Antacids
Gastric Emptying
Therapeutics
Chelating Agents
Gastric Mucosa
Bile
Documentation
Abdominal Pain
Vomiting
Weight Loss
History
Diet
Pain
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Bondurant, F. J., Maull, K. I., Nelson, H., & Silver, S. H. (1987). Bile reflux gastritis. Southern Medical Journal, 80(2), 161-165. https://doi.org/10.1097/00007611-198702000-00005

Bile reflux gastritis. / Bondurant, F. J.; Maull, K. I.; Nelson, Henry; Silver, S. H.

In: Southern Medical Journal, Vol. 80, No. 2, 01.01.1987, p. 161-165.

Research output: Contribution to journalArticle

Bondurant, FJ, Maull, KI, Nelson, H & Silver, SH 1987, 'Bile reflux gastritis', Southern Medical Journal, vol. 80, no. 2, pp. 161-165. https://doi.org/10.1097/00007611-198702000-00005
Bondurant, F. J. ; Maull, K. I. ; Nelson, Henry ; Silver, S. H. / Bile reflux gastritis. In: Southern Medical Journal. 1987 ; Vol. 80, No. 2. pp. 161-165.
@article{49603bd6b78f41bc82504f2d2805b2e4,
title = "Bile reflux gastritis",
abstract = "Bile reflux gastritis is a disabling postgastrectomy condition characterized by abdominal pain, bilious vomiting, and weight loss. The syndrome appears to be caused by free enterogastric reflux of bile and other proximal small bowel constituents. Endoscopic confirmation of bile reflux and documentation of gastritis support the diagnosis but are not specific for it. Results of medical therapy with chelating agents or drugs that promote gastric motility have been disappointing. Diet and antacids frequently aggravate symptoms. The only effective treatment is surgical diversion of bile away from the gastric mucosa. During a recent seven-year period, 15 patients had diversionary operation for bile reflux gastritis diagnosed by history and endoscopic findings. Before operation, medical management had failed to yield improvment in any case. After operation, all patients showed improvement, and pain was relieved in 85{\%}. Based on our experience, we conclude that (1) current medical therapy may alter but not cure symptoms of bile reflux gastritis; (2) Roux-en-Y diversion is the treatment of choice in patients with persistent symptoms; and (3) delayed gastric emptying is a common complication after the Roux-en-Y procedure, but in our series, the incidence was reduced by using the Tanner 19 modification. New cytoprotective agents that may offer an alternative to operation are currently being studied.",
author = "Bondurant, {F. J.} and Maull, {K. I.} and Henry Nelson and Silver, {S. H.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1097/00007611-198702000-00005",
language = "English (US)",
volume = "80",
pages = "161--165",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Bile reflux gastritis

AU - Bondurant, F. J.

AU - Maull, K. I.

AU - Nelson, Henry

AU - Silver, S. H.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Bile reflux gastritis is a disabling postgastrectomy condition characterized by abdominal pain, bilious vomiting, and weight loss. The syndrome appears to be caused by free enterogastric reflux of bile and other proximal small bowel constituents. Endoscopic confirmation of bile reflux and documentation of gastritis support the diagnosis but are not specific for it. Results of medical therapy with chelating agents or drugs that promote gastric motility have been disappointing. Diet and antacids frequently aggravate symptoms. The only effective treatment is surgical diversion of bile away from the gastric mucosa. During a recent seven-year period, 15 patients had diversionary operation for bile reflux gastritis diagnosed by history and endoscopic findings. Before operation, medical management had failed to yield improvment in any case. After operation, all patients showed improvement, and pain was relieved in 85%. Based on our experience, we conclude that (1) current medical therapy may alter but not cure symptoms of bile reflux gastritis; (2) Roux-en-Y diversion is the treatment of choice in patients with persistent symptoms; and (3) delayed gastric emptying is a common complication after the Roux-en-Y procedure, but in our series, the incidence was reduced by using the Tanner 19 modification. New cytoprotective agents that may offer an alternative to operation are currently being studied.

AB - Bile reflux gastritis is a disabling postgastrectomy condition characterized by abdominal pain, bilious vomiting, and weight loss. The syndrome appears to be caused by free enterogastric reflux of bile and other proximal small bowel constituents. Endoscopic confirmation of bile reflux and documentation of gastritis support the diagnosis but are not specific for it. Results of medical therapy with chelating agents or drugs that promote gastric motility have been disappointing. Diet and antacids frequently aggravate symptoms. The only effective treatment is surgical diversion of bile away from the gastric mucosa. During a recent seven-year period, 15 patients had diversionary operation for bile reflux gastritis diagnosed by history and endoscopic findings. Before operation, medical management had failed to yield improvment in any case. After operation, all patients showed improvement, and pain was relieved in 85%. Based on our experience, we conclude that (1) current medical therapy may alter but not cure symptoms of bile reflux gastritis; (2) Roux-en-Y diversion is the treatment of choice in patients with persistent symptoms; and (3) delayed gastric emptying is a common complication after the Roux-en-Y procedure, but in our series, the incidence was reduced by using the Tanner 19 modification. New cytoprotective agents that may offer an alternative to operation are currently being studied.

UR - http://www.scopus.com/inward/record.url?scp=0023293527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023293527&partnerID=8YFLogxK

U2 - 10.1097/00007611-198702000-00005

DO - 10.1097/00007611-198702000-00005

M3 - Article

VL - 80

SP - 161

EP - 165

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 2

ER -