Biliary excretion of aluminum in aluminum osteodystrophy with liver disease

J. W. Williams, S. R. Vera, T. G. Peters, R. W. Luther, Syamal Bhattacharya, H. Spears, A. Graham, J. A. Pitcock, A. J. Crawford, G. M. Palmieri

Research output: Contribution to journalArticle

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Abstract

Two patients with chronic liver disease developed elevated serum aluminum concentrations and biopsy-proven osteodystrophy. Neither patient had chronic renal failure but both had received aluminum-containing antacids for long periods. We measured biliary and urinary aluminum excretion during antacid loading in patients with normal liver function. Our studies show that biliary excretion is an important rout of elimination of orally absorbed aluminum, and we suggest that long-term antacid therapy in patients with severe liver disease be monitored with periodic serum and urinary aluminum determinations to avoid aluminum osteodystrophy.

Original languageEnglish (US)
Pages (from-to)782-785
Number of pages4
JournalAnnals of Internal Medicine
Volume104
Issue number6
DOIs
StatePublished - Jan 1 1986

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Aluminum
Liver Diseases
Antacids
Serum
Chronic Kidney Failure
Hepatobiliary Elimination
Chronic Disease
Biopsy
Liver

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Williams, J. W., Vera, S. R., Peters, T. G., Luther, R. W., Bhattacharya, S., Spears, H., ... Palmieri, G. M. (1986). Biliary excretion of aluminum in aluminum osteodystrophy with liver disease. Annals of Internal Medicine, 104(6), 782-785. https://doi.org/10.7326/0003-4819-104-6-782

Biliary excretion of aluminum in aluminum osteodystrophy with liver disease. / Williams, J. W.; Vera, S. R.; Peters, T. G.; Luther, R. W.; Bhattacharya, Syamal; Spears, H.; Graham, A.; Pitcock, J. A.; Crawford, A. J.; Palmieri, G. M.

In: Annals of Internal Medicine, Vol. 104, No. 6, 01.01.1986, p. 782-785.

Research output: Contribution to journalArticle

Williams, JW, Vera, SR, Peters, TG, Luther, RW, Bhattacharya, S, Spears, H, Graham, A, Pitcock, JA, Crawford, AJ & Palmieri, GM 1986, 'Biliary excretion of aluminum in aluminum osteodystrophy with liver disease', Annals of Internal Medicine, vol. 104, no. 6, pp. 782-785. https://doi.org/10.7326/0003-4819-104-6-782
Williams, J. W. ; Vera, S. R. ; Peters, T. G. ; Luther, R. W. ; Bhattacharya, Syamal ; Spears, H. ; Graham, A. ; Pitcock, J. A. ; Crawford, A. J. ; Palmieri, G. M. / Biliary excretion of aluminum in aluminum osteodystrophy with liver disease. In: Annals of Internal Medicine. 1986 ; Vol. 104, No. 6. pp. 782-785.
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