Biochemical and immunologic characterization of an oncornavirus glycoprotein

Stephen Kennel, B. C. DelVillano, R. L. Levy, R. A. Lerner

Research output: Contribution to journalArticle

Abstract

Studies were carried out on cancerogenic C type virus, Scripps leukemia virus (SLV), produced by a lymphoblastoid cell line (SCRF 60A) from a New Zealand Black (NZB) mouse. A 70,000 dalton glycoprotein on the virion surface constitutes about 10% of the virion amino acids and about 50% of the glucosamine. The protein can be isolated from surface iodinated SCRF 60A cells as well as from a line of nonproducer cells. This protein reacts with sera which neutralize Moloney, Kirsten, Rauscher, AKR, and, of course Scripps viruses. These data suggest that this is the principal antigen detected by immunofluorescence on the surface of cells infected with murine leukemia virus (MuLV) and that this antigen may be involved in virus neutralization.

Original languageEnglish (US)
Pages (from-to)329-338
Number of pages10
JournalBibliotheca Haematologica
VolumeNo.40
StatePublished - Dec 1 1975

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Retroviridae
Glycoproteins
Viruses
Virion
Antigens
Murine Leukemia Viruses
Glucosamine
New Zealand
Fluorescent Antibody Technique
Leukemia
Proteins
Amino Acids
Cell Line
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kennel, S., DelVillano, B. C., Levy, R. L., & Lerner, R. A. (1975). Biochemical and immunologic characterization of an oncornavirus glycoprotein. Bibliotheca Haematologica, No.40, 329-338.

Biochemical and immunologic characterization of an oncornavirus glycoprotein. / Kennel, Stephen; DelVillano, B. C.; Levy, R. L.; Lerner, R. A.

In: Bibliotheca Haematologica, Vol. No.40, 01.12.1975, p. 329-338.

Research output: Contribution to journalArticle

Kennel, S, DelVillano, BC, Levy, RL & Lerner, RA 1975, 'Biochemical and immunologic characterization of an oncornavirus glycoprotein', Bibliotheca Haematologica, vol. No.40, pp. 329-338.
Kennel, Stephen ; DelVillano, B. C. ; Levy, R. L. ; Lerner, R. A. / Biochemical and immunologic characterization of an oncornavirus glycoprotein. In: Bibliotheca Haematologica. 1975 ; Vol. No.40. pp. 329-338.
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