Biochemotherapy in patients with advanced head and neck mucosal melanoma

Holly L. Bartell, Agop Y. Bedikian, Nicholas E. Papadopoulos, Tina K. Dett, Matthew Ballo, Jeffrey N. Myers, Patrick Hwu, Kevin B. Kim

Research output: Contribution to journalArticle

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Abstract

Background. No systemic therapy regimen has been recognized as effective for metastatic mucosal melanoma of the head and neck. We retrospectively analyzed the effectiveness of biochemotherapy in patients with advanced head and neck mucosal melanoma. Methods. We evaluated the medical records of 15 patients at our institution who had received various biochemotherapy regimens for advanced head and neck mucosal melanoma. Results. After a median follow-up duration of 13 months, 3 patients (20%) had partial response, and 4 patients (27%) had complete response. The median time to disease progression for all 15 patients was 10 months. The median overall survival duration for all patients was 22 months. Conclusions. Although this was a small study, our results, especially the high complete response and overall response rates, indicate that biochemotherapy for advanced head and neck mucosal melanoma should be considered as a systemic treatment option for patients with this aggressive malignancy.

Original languageEnglish (US)
Pages (from-to)1592-1598
Number of pages7
JournalHead and Neck
Volume30
Issue number12
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

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Melanoma
Neck
Head
Medical Records
Disease Progression
Survival
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Bartell, H. L., Bedikian, A. Y., Papadopoulos, N. E., Dett, T. K., Ballo, M., Myers, J. N., ... Kim, K. B. (2008). Biochemotherapy in patients with advanced head and neck mucosal melanoma. Head and Neck, 30(12), 1592-1598. https://doi.org/10.1002/hed.20910

Biochemotherapy in patients with advanced head and neck mucosal melanoma. / Bartell, Holly L.; Bedikian, Agop Y.; Papadopoulos, Nicholas E.; Dett, Tina K.; Ballo, Matthew; Myers, Jeffrey N.; Hwu, Patrick; Kim, Kevin B.

In: Head and Neck, Vol. 30, No. 12, 01.12.2008, p. 1592-1598.

Research output: Contribution to journalArticle

Bartell, HL, Bedikian, AY, Papadopoulos, NE, Dett, TK, Ballo, M, Myers, JN, Hwu, P & Kim, KB 2008, 'Biochemotherapy in patients with advanced head and neck mucosal melanoma', Head and Neck, vol. 30, no. 12, pp. 1592-1598. https://doi.org/10.1002/hed.20910
Bartell HL, Bedikian AY, Papadopoulos NE, Dett TK, Ballo M, Myers JN et al. Biochemotherapy in patients with advanced head and neck mucosal melanoma. Head and Neck. 2008 Dec 1;30(12):1592-1598. https://doi.org/10.1002/hed.20910
Bartell, Holly L. ; Bedikian, Agop Y. ; Papadopoulos, Nicholas E. ; Dett, Tina K. ; Ballo, Matthew ; Myers, Jeffrey N. ; Hwu, Patrick ; Kim, Kevin B. / Biochemotherapy in patients with advanced head and neck mucosal melanoma. In: Head and Neck. 2008 ; Vol. 30, No. 12. pp. 1592-1598.
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