Biological functions of a novel lipid mediator, cyclic phosphatidic acid

Kimiko Murakami-Murofushi, Ayako Uchiyama, Yuko Fujiwara, Tetsuyuki Kobayashi, Susumu Kobayashi, Mutsuko Mukai, Hiromu Murofushi, Gabor Tigyi

Research output: Contribution to journalReview article

58 Citations (Scopus)

Abstract

A novel bioactive lipid, cyclic phosphatidic acid (cPA), was isolated originally from myxoamoebae of a true slime mold, Physarum polycephalum, and has now been detected in a wide range of organisms from slime molds to humans. It has a cyclic phosphate at the sn-2 and sn-3 positions of the glycerol carbons, and this structure is absolutely necessary for its activities. This substance shows specific biological functions, including antimitogenic regulation of the cell cycle, regulation of actin stress fiber formation and rearrangement, inhibition of cancer cell invasion and metastasis, regulation of differentiation and viability of neuronal cells, and mobilization of intracellular calcium. Although the structure of cPA is similar to that of lysophosphatidic acid (LPA), its biological activities are apparently distinct from those of LPA. In the present review, we focus mainly on the enzymatic formation of cPA, the antimitogenic regulation of the cell cycle, the inhibition of cancer cell invasion and metastasis, and the neurotrophic effect of cPA.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1582
Issue number1-3
DOIs
StatePublished - May 23 2002

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Phosphatidic Acids
Lipids
Cell Cycle
Myxomycetes
Physarum polycephalum
Neoplasm Metastasis
Stress Fibers
Glycerol
Actins
Neoplasms
Cell Survival
Fungi
Carbon
Phosphates
Calcium
lysophosphatidic acid

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Biological functions of a novel lipid mediator, cyclic phosphatidic acid. / Murakami-Murofushi, Kimiko; Uchiyama, Ayako; Fujiwara, Yuko; Kobayashi, Tetsuyuki; Kobayashi, Susumu; Mukai, Mutsuko; Murofushi, Hiromu; Tigyi, Gabor.

In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1582, No. 1-3, 23.05.2002, p. 1-7.

Research output: Contribution to journalReview article

Murakami-Murofushi, K, Uchiyama, A, Fujiwara, Y, Kobayashi, T, Kobayashi, S, Mukai, M, Murofushi, H & Tigyi, G 2002, 'Biological functions of a novel lipid mediator, cyclic phosphatidic acid', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1582, no. 1-3, pp. 1-7. https://doi.org/10.1016/S1388-1981(02)00131-2
Murakami-Murofushi, Kimiko ; Uchiyama, Ayako ; Fujiwara, Yuko ; Kobayashi, Tetsuyuki ; Kobayashi, Susumu ; Mukai, Mutsuko ; Murofushi, Hiromu ; Tigyi, Gabor. / Biological functions of a novel lipid mediator, cyclic phosphatidic acid. In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2002 ; Vol. 1582, No. 1-3. pp. 1-7.
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