Biomarkers of Resilience in Stress Reduction for Caregivers of Alzheimer’s Patients

Lap Ho, Patricia A. Bloom, Joan G. Vega, Shrishailam Yemul, Wei Zhao, Libby Ward, Evan Savage, Robert Rooney, Divyen H. Patel, Giulio Maria Pasinetti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Caregiving for a dementia patient is associated with increased risk of psychological and physical health problems. We investigated whether a mindfulness-based stress reduction (MBSR) training course for caregivers that closely models the MBSR curriculum originally established by the Center of Mindfulness at the University of Massachusetts may improve the psychological resilience of non-professional caregivers of Alzheimer’s disease patients. Twenty adult non-professional caregivers of dementia patients participated in an 8-week MBSR training course. Caregiver stress, depression, burden, grief, and gene expression profiles of blood mononuclear cells were assessed at baseline and following MBSR. MBSR training significantly improved the psychological resilience of some of the caregivers. We identified predictive biomarkers whose expression is associated with the likelihood of caregivers to benefit from MBSR, and biomarkers whose expression is associated with MBSR psychological benefits. Our biomarker studies provide insight into the mechanisms of health benefits of MBSR and a basis for developing a personalized medicine approach for applying MBSR for promoting psychological and cognitive resilience in caregivers of dementia patients.

Original languageEnglish (US)
Pages (from-to)177-189
Number of pages13
JournalNeuroMolecular Medicine
Volume18
Issue number2
DOIs
StatePublished - Jun 1 2016

Fingerprint

Mindfulness
Caregivers
Biomarkers
Psychological Resilience
Dementia
Precision Medicine
Grief
Insurance Benefits
Transcriptome
Psychological Stress
Curriculum
Blood Cells
Alzheimer Disease
Depression
Psychology

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Ho, L., Bloom, P. A., Vega, J. G., Yemul, S., Zhao, W., Ward, L., ... Pasinetti, G. M. (2016). Biomarkers of Resilience in Stress Reduction for Caregivers of Alzheimer’s Patients. NeuroMolecular Medicine, 18(2), 177-189. https://doi.org/10.1007/s12017-016-8388-8

Biomarkers of Resilience in Stress Reduction for Caregivers of Alzheimer’s Patients. / Ho, Lap; Bloom, Patricia A.; Vega, Joan G.; Yemul, Shrishailam; Zhao, Wei; Ward, Libby; Savage, Evan; Rooney, Robert; Patel, Divyen H.; Pasinetti, Giulio Maria.

In: NeuroMolecular Medicine, Vol. 18, No. 2, 01.06.2016, p. 177-189.

Research output: Contribution to journalArticle

Ho, L, Bloom, PA, Vega, JG, Yemul, S, Zhao, W, Ward, L, Savage, E, Rooney, R, Patel, DH & Pasinetti, GM 2016, 'Biomarkers of Resilience in Stress Reduction for Caregivers of Alzheimer’s Patients', NeuroMolecular Medicine, vol. 18, no. 2, pp. 177-189. https://doi.org/10.1007/s12017-016-8388-8
Ho, Lap ; Bloom, Patricia A. ; Vega, Joan G. ; Yemul, Shrishailam ; Zhao, Wei ; Ward, Libby ; Savage, Evan ; Rooney, Robert ; Patel, Divyen H. ; Pasinetti, Giulio Maria. / Biomarkers of Resilience in Stress Reduction for Caregivers of Alzheimer’s Patients. In: NeuroMolecular Medicine. 2016 ; Vol. 18, No. 2. pp. 177-189.
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