Biomolecular Electronics

Protein-Based Associative Processors and Volumetric Memories

Robert R. Birge, Nathan B. Gillespie, Enrique Izaguirre, Anakarin Kusnetzow, Albert F. Lawrence, Deepak Singh, Q. Wang Song, Edward Schmidt, Jeffrey A. Stuart, Sukeerthi Seetharaman, Kevin J. Wise

Research output: Contribution to journalArticle

243 Citations (Scopus)

Abstract

The promise of new architectures and more cost-effective miniaturization has prompted interest in molecular and biomolecular electronics. Bioelectronics offers valuable near-term potential, because evolution and natural selection have optimized many biological molecules to perform tasks that are required for device applications. The light-transducing protein bacteriorhodopsin provides not only an efficient photonic material, but also a versatile template for device creation and optimization via both chemical modification and genetic engineering. We examine here the use of this protein as the active component in holographic associative memories as well as branched-photocycle three-dimensional optical memories. The associative memory is based on a Fourier transform optical loop and utilizes the real-time holographic properties of the protein thin films. The three-dimensional memory utilizes an unusual branching reaction that creates a long-lived photoproduct. By using a sequential multiphoton process, parallel write, read, and erase processes can be carried out without disturbing data outside of the doubly irradiated volume elements. The methods and procedures of prototyping these bioelectronic devices are discussed. We also examine current efforts to optimize the protein memory medium by using chemical and genetic methods.

Original languageEnglish (US)
Pages (from-to)10746-10766
Number of pages21
JournalJournal of Physical Chemistry B
Volume103
Issue number49
StatePublished - Dec 9 1999
Externally publishedYes

Fingerprint

central processing units
Electronic equipment
proteins
Proteins
Data storage equipment
associative memory
electronics
Multiphoton processes
Bacteriorhodopsins
Genetic engineering
Optical data storage
molecular electronics
Chemical modification
miniaturization
Photonics
Fourier transforms
templates
engineering
photonics
costs

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Birge, R. R., Gillespie, N. B., Izaguirre, E., Kusnetzow, A., Lawrence, A. F., Singh, D., ... Wise, K. J. (1999). Biomolecular Electronics: Protein-Based Associative Processors and Volumetric Memories. Journal of Physical Chemistry B, 103(49), 10746-10766.

Biomolecular Electronics : Protein-Based Associative Processors and Volumetric Memories. / Birge, Robert R.; Gillespie, Nathan B.; Izaguirre, Enrique; Kusnetzow, Anakarin; Lawrence, Albert F.; Singh, Deepak; Song, Q. Wang; Schmidt, Edward; Stuart, Jeffrey A.; Seetharaman, Sukeerthi; Wise, Kevin J.

In: Journal of Physical Chemistry B, Vol. 103, No. 49, 09.12.1999, p. 10746-10766.

Research output: Contribution to journalArticle

Birge, RR, Gillespie, NB, Izaguirre, E, Kusnetzow, A, Lawrence, AF, Singh, D, Song, QW, Schmidt, E, Stuart, JA, Seetharaman, S & Wise, KJ 1999, 'Biomolecular Electronics: Protein-Based Associative Processors and Volumetric Memories', Journal of Physical Chemistry B, vol. 103, no. 49, pp. 10746-10766.
Birge RR, Gillespie NB, Izaguirre E, Kusnetzow A, Lawrence AF, Singh D et al. Biomolecular Electronics: Protein-Based Associative Processors and Volumetric Memories. Journal of Physical Chemistry B. 1999 Dec 9;103(49):10746-10766.
Birge, Robert R. ; Gillespie, Nathan B. ; Izaguirre, Enrique ; Kusnetzow, Anakarin ; Lawrence, Albert F. ; Singh, Deepak ; Song, Q. Wang ; Schmidt, Edward ; Stuart, Jeffrey A. ; Seetharaman, Sukeerthi ; Wise, Kevin J. / Biomolecular Electronics : Protein-Based Associative Processors and Volumetric Memories. In: Journal of Physical Chemistry B. 1999 ; Vol. 103, No. 49. pp. 10746-10766.
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