Biosynthesis of neopterin, sepiapterin, and biopterin in rat and human ocular tissues

Rao Gadiparthi, E. Cotlier

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Neopterin, sepiapterin, and biopterin synthesis by lens, retina, and ciliary body-iris of rat and human indicates pteridine formation from their precursor, GTP. The pteridine biosynthesis was higher in the retina (neopterin 422 ± 27, 260 ± 24; sepiapterin 135 ± 12, 118 ± 14; biopterin 76 ± 10, 68 ± 8 nanomoles/g soluble protein/hr, in rat and human, respectively) than in the ciliary body-iris and lens. The light-sensitive pteridines may protect eye tissues against the effects of sunlight in addition to their role in the hydroxylation of aromatic amino acids.

Original languageEnglish (US)
Pages (from-to)768-770
Number of pages3
JournalInvestigative Ophthalmology and Visual Science
Volume26
Issue number5
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Biopterin
Pteridines
Neopterin
Ciliary Body
Iris
Lenses
Retina
Aromatic Amino Acids
Sunlight
Hydroxylation
Guanosine Triphosphate
Light
sepiapterin

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Biosynthesis of neopterin, sepiapterin, and biopterin in rat and human ocular tissues. / Gadiparthi, Rao; Cotlier, E.

In: Investigative Ophthalmology and Visual Science, Vol. 26, No. 5, 01.01.1985, p. 768-770.

Research output: Contribution to journalArticle

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