Biotransformation, elimination and bile acid metabolism

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The liver detoxifies and excretes both exogenous xenobiotics, such as drugs and environmental toxins, and endogenous substances, including ammonia and bilirubin. Efficient processing and elimination of these substances prevent cellular injury, including CNS toxicity in the case of ammonia and bilirubin. Hepatic synthesis, secretion and re-uptake of bile acids is an exquisitely regulated process that allows modulation of cholesterol metabolism and efficient absorption of the products of fat digestion, as well as compensatory trafficking of bile acids out of the hepatocyte in the face of bile acid retention as occurs in cholestasis. Nuclear receptor transcription factors tightly regulate these processes and offer potential therapeutic targets for new approaches to treatment of a variety of diseases. This chapter reviews these important functions of the liver, underscoring another aspect of its central role in human physiology.

Original languageEnglish (US)
Title of host publicationThe Gastrointestinal System
Subtitle of host publicationGastrointestinal, Nutritional and Hepatobiliary Physiology
PublisherSpringer Netherlands
Pages295-324
Number of pages30
ISBN (Electronic)9789401787710
ISBN (Print)9789401787703
DOIs
StatePublished - Jan 1 2014

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Biotransformation
Bile Acids and Salts
Bilirubin
Ammonia
Liver
Cholestasis
Xenobiotics
Cytoplasmic and Nuclear Receptors
Digestion
Hepatocytes
Transcription Factors
Fats
Cholesterol
Wounds and Injuries
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Black, D. (2014). Biotransformation, elimination and bile acid metabolism. In The Gastrointestinal System: Gastrointestinal, Nutritional and Hepatobiliary Physiology (pp. 295-324). Springer Netherlands. https://doi.org/10.1007/978-94-017-8771-0_12

Biotransformation, elimination and bile acid metabolism. / Black, Dennis.

The Gastrointestinal System: Gastrointestinal, Nutritional and Hepatobiliary Physiology. Springer Netherlands, 2014. p. 295-324.

Research output: Chapter in Book/Report/Conference proceedingChapter

Black, D 2014, Biotransformation, elimination and bile acid metabolism. in The Gastrointestinal System: Gastrointestinal, Nutritional and Hepatobiliary Physiology. Springer Netherlands, pp. 295-324. https://doi.org/10.1007/978-94-017-8771-0_12
Black D. Biotransformation, elimination and bile acid metabolism. In The Gastrointestinal System: Gastrointestinal, Nutritional and Hepatobiliary Physiology. Springer Netherlands. 2014. p. 295-324 https://doi.org/10.1007/978-94-017-8771-0_12
Black, Dennis. / Biotransformation, elimination and bile acid metabolism. The Gastrointestinal System: Gastrointestinal, Nutritional and Hepatobiliary Physiology. Springer Netherlands, 2014. pp. 295-324
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