Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central california population

Roy R. Gerona, Tracey J. Woodruff, Carrie A. Dickenson, Janet Pan, Jackie M. Schwartz, Saunak Sen, Matthew W. Friesen, Victor Y. Fujimoto, Patricia A. Hunt

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Bisphenol-A (BPA) is an endocrine disrupting chemical used in numerous consumer products, resulting in universal exposure in the United States. Prenatal exposure to BPA is associated with numerous reproductive and developmental effects in animals. However, little is known about human fetal exposure or metabolism of BPA during midgestation. In the present study, we present a new liquid chromatography-tandem mass spectrometry method to directly measure concentrations of BPA and two predominant metabolic conjugates - BPA glucuronide and BPA sulfate - in umbilical cord serum collected from elective second trimester pregnancy terminations. We detected at least one form of BPA in all umbilical cord serum samples: BPA (GM 0.16, range <LOD-52.26 ng/mL), BPA glucuronide (GM 0.14, range <LOD-5.41 ng/mL) and BPA sulfate (GM 0.32, range <LOD-12.65 ng/mL). Levels of BPA ranged from less than 1/100th to over 400 times higher than levels of BPA in conjugated form. Although levels of BPA in conjugated form exceeded BPA levels in about 3/4 of the samples, BPA levels were higher in samples with total BPA above the median. Our findings suggest universal fetal exposure to BPA in our study population, with some at relatively high levels, and we provide the first evidence of detectable BPA sulfate in midgestation fetuses.

Original languageEnglish (US)
Pages (from-to)12477-12485
Number of pages9
JournalEnvironmental Science and Technology
Volume47
Issue number21
DOIs
StatePublished - Nov 5 2013

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Sulfates
serum
sulfate
pregnancy
liquid chromatography
mass spectrometry
metabolism
exposure
bisphenol A glucuronide
bisphenol A
animal
Endocrine Disruptors
Consumer products
Liquid chromatography
Metabolism
Mass spectrometry
Animals

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central california population. / Gerona, Roy R.; Woodruff, Tracey J.; Dickenson, Carrie A.; Pan, Janet; Schwartz, Jackie M.; Sen, Saunak; Friesen, Matthew W.; Fujimoto, Victor Y.; Hunt, Patricia A.

In: Environmental Science and Technology, Vol. 47, No. 21, 05.11.2013, p. 12477-12485.

Research output: Contribution to journalArticle

Gerona, RR, Woodruff, TJ, Dickenson, CA, Pan, J, Schwartz, JM, Sen, S, Friesen, MW, Fujimoto, VY & Hunt, PA 2013, 'Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central california population', Environmental Science and Technology, vol. 47, no. 21, pp. 12477-12485. https://doi.org/10.1021/es402764d
Gerona, Roy R. ; Woodruff, Tracey J. ; Dickenson, Carrie A. ; Pan, Janet ; Schwartz, Jackie M. ; Sen, Saunak ; Friesen, Matthew W. ; Fujimoto, Victor Y. ; Hunt, Patricia A. / Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central california population. In: Environmental Science and Technology. 2013 ; Vol. 47, No. 21. pp. 12477-12485.
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