Blink-related sensorimotor anatomy in the rat

Suzhen Gong, Qihong Zhou, Mark Ledoux

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Protection of the eye and maintenance of the precorneal tear film depend on sensory innervation of the cornea and eyelids and motor innervation of muscles involved in closing and opening the eyes. Using a variety of fluorescent and transganglionic tracers, the sensorimotor innervation of blink-related orbital and periorbital structures was studied in Sprague-Dawley rats. The orbicularis oculi muscle surrounded the entire palpebral fissure and was innervated by motoneurons located along the dorsal cap of the ipsilateral facial motor nucleus. Upper and lower eyelid orbicularis oculi motoneurons were strictly ipsilateral and co-extensive, but upper eyelid orbicularis oculi motoneurons were, on average, slightly rostral and lateral to lower eyelid orbicularis oculi motoneurons. Facial motoneurons supplying the frontoscutularis, a muscle that helps to elevate the upper eyelid, were located in the medial division of the ipsilateral facial motor nucleus. Presumptive type Aβ afferents from the cornea terminated most prominently at the junction of the first cervical segment and the spinal trigeminal nucleus, pars caudalis. There was a second concentration of corneal terminations at the junction of pars caudalis and pars interpolaris of the spinal trigeminal nucleus. Sparse projections to the spinal trigeminal nucleus, pars oralis and the principal trigeminal nucleus were also detected. Presumptive type Aβ afferents from the eyelids terminated throughout the rostrocaudal extent of the spinal trigeminal nucleus with a heavy concentration within laminae III and IV of the first cervical segment. Presumptive types Aδ and C terminals from the eyelids were virtually limited to laminae I and II of the first cervical segment. Central terminations from the frontal nerve were present in the principal trigeminal nucleus and throughout the spinal trigeminal nucleus, but were most prominent within the dorsal horn of the first cervical segment. Our comprehensive description of blink-related sensorimotor anatomy in rats will provide a foundation for future physiological studies of blinking.

Original languageEnglish (US)
Pages (from-to)193-208
Number of pages16
JournalAnatomy and Embryology
Volume207
Issue number3
DOIs
StatePublished - Oct 1 2003

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Eyelids
Spinal Trigeminal Nucleus
Anatomy
Motor Neurons
Trigeminal Nuclei
Muscles
Cornea
Substantia Gelatinosa
Blinking
Tears
Sprague Dawley Rats
Maintenance
Spinal Cord Dorsal Horn

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Embryology
  • Developmental Biology
  • Cell Biology

Cite this

Blink-related sensorimotor anatomy in the rat. / Gong, Suzhen; Zhou, Qihong; Ledoux, Mark.

In: Anatomy and Embryology, Vol. 207, No. 3, 01.10.2003, p. 193-208.

Research output: Contribution to journalArticle

Gong, Suzhen ; Zhou, Qihong ; Ledoux, Mark. / Blink-related sensorimotor anatomy in the rat. In: Anatomy and Embryology. 2003 ; Vol. 207, No. 3. pp. 193-208.
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