Blood platelet uptake of serotonin in episodic aggression

Candace Brown, Thomas A. Kent, Stephen G. Bryant, Robert M. Gevedon, Jan L. Campbell, Alan R. Felthous, Ernest S. Barratt, Robert M. Rose

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Blood platelet uptake of 3H-serotonin (5HT uptake), a potential marker of serotonergic function, was determined in male outpatients with episodic aggression (n= 15) and in age- and sex-matched nonaggressive controls (n= 15). Correlations with rating scales of "impulsivity" (Barratt Impulsivity Scale, 10th revision) and "anger" (Spielberger Anger Expression Scale) were performed. Mean 5HT uptake was 18% lower in patients with episodic aggression. A significant negative correlation between % difference in platelet 5HT uptake and impulsivity score was observed, but the correlation between 5HT uptake and anger was not significant. These results support the hypothesis of disturbed serotonergic function in aggression and suggest that the primary relationship is in the "control" of aggression. The blood platelet may be useful in identifying impulsive subtypes.

Original languageEnglish (US)
Pages (from-to)5-12
Number of pages8
JournalPsychiatry Research
Volume27
Issue number1
DOIs
StatePublished - Jan 1 1989

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Aggression
Impulsive Behavior
Serotonin
Blood Platelets
Anger
Outpatients

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Brown, C., Kent, T. A., Bryant, S. G., Gevedon, R. M., Campbell, J. L., Felthous, A. R., ... Rose, R. M. (1989). Blood platelet uptake of serotonin in episodic aggression. Psychiatry Research, 27(1), 5-12. https://doi.org/10.1016/0165-1781(89)90003-6

Blood platelet uptake of serotonin in episodic aggression. / Brown, Candace; Kent, Thomas A.; Bryant, Stephen G.; Gevedon, Robert M.; Campbell, Jan L.; Felthous, Alan R.; Barratt, Ernest S.; Rose, Robert M.

In: Psychiatry Research, Vol. 27, No. 1, 01.01.1989, p. 5-12.

Research output: Contribution to journalArticle

Brown, C, Kent, TA, Bryant, SG, Gevedon, RM, Campbell, JL, Felthous, AR, Barratt, ES & Rose, RM 1989, 'Blood platelet uptake of serotonin in episodic aggression', Psychiatry Research, vol. 27, no. 1, pp. 5-12. https://doi.org/10.1016/0165-1781(89)90003-6
Brown C, Kent TA, Bryant SG, Gevedon RM, Campbell JL, Felthous AR et al. Blood platelet uptake of serotonin in episodic aggression. Psychiatry Research. 1989 Jan 1;27(1):5-12. https://doi.org/10.1016/0165-1781(89)90003-6
Brown, Candace ; Kent, Thomas A. ; Bryant, Stephen G. ; Gevedon, Robert M. ; Campbell, Jan L. ; Felthous, Alan R. ; Barratt, Ernest S. ; Rose, Robert M. / Blood platelet uptake of serotonin in episodic aggression. In: Psychiatry Research. 1989 ; Vol. 27, No. 1. pp. 5-12.
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