Blood pressure and risk of death from external causes among men screened for the Multiple Risk Factor Intervention Trial

Paul Terry, Jerome L. Abramson, James D. Neaton

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22 Citations (Scopus)

Abstract

A few epidemiologic studies have shown an increased risk of death from external causes among men with hypertension. Previous studies were limited by small numbers of events, however, and none assessed the association of blood pressure with specific types of "accidental" death. The authors examined data obtained from baseline interviews and 25 years of mortality follow-up (1973-1999) for 347,978 men screened for the US Multiple Risk Factor Intervention Trial. Proportional hazards regression analyses were used to quantify associations of blood pressure with all external causes of death and individual causes. There were 3,910 deaths from external causes, including 2,313 unintentional injuries, 1,248 suicides, and 349 homicides. Compared with those for men whose blood pressure status was "normal" according to the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, the multivariate-adjusted hazard ratios and 95% confidence intervals for death from external causes among men with prehypertension, stage 1 hypertension, and stage 2 hypertension were 0.91 (95% confidence interval (CI): 0.83, 1.00), 1.06 (95% CI: 0.96, 1.16), and 1.44 (95% CI: 1.28, 1.62), respectively. Men with stage 2 hypertension had multivariate-adjusted hazard ratios of 1.90 for falls (95% CI: 1.32, 2.74), 1.45 for motor vehicle injuries (95% CI: 1.14, 1.85), 1.33 for other "accidents" (95% CI: 1.06, 1.66), 1.40 for suicide (95% CI: 1.13, 1.73), and 1.35 for homicide (95% CI: 0.92, 1.97). For men, hypertension may signal an increased risk of death from external causes.

Original languageEnglish (US)
Pages (from-to)294-301
Number of pages8
JournalAmerican Journal of Epidemiology
Volume165
Issue number3
DOIs
StatePublished - Feb 1 2007
Externally publishedYes

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Cause of Death
Confidence Intervals
Blood Pressure
Hypertension
Homicide
Suicide
Prehypertension
Wounds and Injuries
Motor Vehicles
Accidents
Epidemiologic Studies
Regression Analysis
Interviews
Mortality

All Science Journal Classification (ASJC) codes

  • Epidemiology

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Blood pressure and risk of death from external causes among men screened for the Multiple Risk Factor Intervention Trial. / Terry, Paul; Abramson, Jerome L.; Neaton, James D.

In: American Journal of Epidemiology, Vol. 165, No. 3, 01.02.2007, p. 294-301.

Research output: Contribution to journalArticle

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